Asian Cohort for Alzheimer's Disease (ACAD)

亚洲阿尔茨海默病队列 (ACAD)

• 批准号: 10263300
• 负责人: HELENA Chang CHUI
• 金额: $ 243.58万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263300
• 关键词: Address; Affect; African; African American; Age; Alleles; Alzheimer' s Disease; Alzheimer' s Disease Pathway; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Asian Americans; Asian Indian; Asians; Biology; Body mass index; Canada; Caregivers; Chinese People; Clinic; Clinical; Clinical Data; Clinical Research; Collaborations; Communities; Community Outreach; Complex; DNA; Data; Data Collection; Dementia; Diabetes Mellitus; Diagnosis; Disease; Education; Ethnic group; European; Evaluation; Exposure to; Failure; Filipino; Foundations; Frequencies; Future; Genes; Genetic; Genetic Diseases; Genetic Markers; Genetic Research; Genetic Risk; Genetic study; Genomics; Genotype; Goals; Hispanics; Human Genetics; Hypertension; Impaired cognition; International; Investments; Japanese Population; Knowledge; Koreans; Language; Late Onset Alzheimer Disease; Leadership; Life Style; Literature; Meta-Analysis; Minority Groups; Natural Immunity; Nursing Homes; Office Nursing; Participant; Pathway interactions; Patient Recruitments; Patients; Physical activity; Population; Prevention; Process; Protocols documentation; Recording of previous events; Research; Resources; Risk; Risk Factors; SNP array; Saliva; Sample Size; Sampling; Scientist; Site; Smoking; South Asian; Standardization; Structure; Subgroup; Therapeutic; Training Programs; United States; Vision; aged; clinical diagnostics; clinical predictors; cohort; cost; data resource; dementia risk; experience; genetic risk factor; genetic variant; genome sequencing; genome wide association study; genome-wide; insight; instrument; lifestyle factors; lipid transport; metropolitan; new therapeutic target; non-genetic; novel; outreach; outreach program; process repeatability; recruit; risk variant; screening; sex; success; tau Proteins; whole genome

Project Summary Alzheimer's disease (AD) affects 5.8 million people in the United States and is an immense burden on our economy, patients and caregivers. Genome-wide association studies (GWAS) have successfully led to 25 genome-wide significant loci associated with AD risk and many more associations with key clinical covariates. Most of these findings are made on participants with European ancestry, although efforts to study other minority populations are taking off. Knowledge about AD genetics among Asian Americans is especially limited due to lack of participants. Comprising 6% of the US populace, Asian Americans are under-sampled and deserve more scientific investment. We propose the Asian Cohort for Alzheimer's Disease (ACAD), the first large Alzheimer's Disease (AD) genetics cohort for Asians in United States (US) and Canada. To optimize ACAD's success, we assembled a team of scientists, clinicians, and community partners with collaborative history and expertise in AD research, human genetics, and Asian community outreach. We propose to recruit 5,970 participants aged 60 years or older and of Chinese, Korean, and Vietnamese ancestry from metropolitan areas across the US and Canada in collaboration with community partners, clinics, or nursing homes that serve Asian communities. We will collect saliva for DNA and use validated, localized instruments, data forms, and clinical/diagnostic protocols. To support these recruitment and data collection activities, we will set up a coordinating center and develop governance, community outreach and training programs to support recruitment and analysis activities, and conduct a process evaluation of the recruitment and outreach efforts. All samples will be genotyped using SNP arrays and imputed using a large Asian-specific reference panel of whole genome sequencing data from international Asian cohorts. We will analyze genetic and clinical data to investigate impact of lifestyle risk factors, genetic variants for AD risk, evaluate differential effects of sex and APOE genotypes on AD risk, and predict clinical diagnosis of AD using genetic and lifestyle risk scores. We will replicate these findings through meta-analysis collaborations with international Asian cohorts and AD studies from other populations. Comprising 6% of the US populace, Asian Americans are under-sampled and deserve more scientific investment in Alzheimer's disease research. The ACAD project will build the first major AD genetics study for Asians in the US and Canada. Successful completion will lead to new genetic and lifestyle screening markers for Asian Americans and insights about novel therapeutic targets for AD. ACAD will be a first network for recruiting and studying AD in Asian Americans that will extend to Asian Indians, Filipino and other Asian American populations in the future, serving the unmet needs of Alzheimer's disease research for Asian Americans.

项目概要 阿尔茨海默病 (AD) 影响着美国 580 万人，给我们带来了巨大的负担 经济、患者和护理人员。全基因组关联研究 (GWAS) 已成功得出 25 与 AD 风险相关的全基因组显着位点以及与关键临床协变量的更多关联。 这些发现大部分是针对具有欧洲血统的参与者，尽管努力研究其他 少数民族人口正在起飞。亚裔美国人对 AD 遗传学的了解尤其有限 由于缺乏参与者。亚裔美国人占美国人口的 6%，样本不足， 值得更多的科学投资。 我们提出亚洲阿尔茨海默病队列 (ACAD)，这是第一个大型阿尔茨海默病 (AD) 美国和加拿大的亚洲人遗传学队列。为了优化 ACAD 的成功，我们组建了 由科学家、临床医生和社区合作伙伴组成的团队，在 AD 研究方面具有合作历史和专业知识， 人类遗传学和亚洲社区外展。我们建议招募 5,970 名 60 岁或以上的参与者 来自美国和加拿大大都市地区的老年人，有中国、韩国和越南血统 与服务亚洲社区的社区合作伙伴、诊所或疗养院合作。我们将收集 唾液中的 DNA 并使用经过验证的本地化仪器、数据表格和临床/诊断方案。到 为了支持这些招聘和数据收集活动，我们将设立一个协调中心并制定 支持招募和分析活动的治理、社区外展和培训计划，以及 对招聘和外展工作进行过程评估。所有样本均将使用 SNP 进行基因分型 阵列并使用来自亚洲的全基因组测序数据的大型亚洲特定参考面板进行估算 国际亚洲群体。我们将分析遗传和临床数据以调查生活方式风险的影响 AD 风险的因素、遗传变异，评估性别和 APOE 基因型对 AD 风险的差异影响，以及 使用遗传和生活方式风险评分预测 AD 的临床诊断。我们将通过重复这些发现 与国际亚洲队列和其他人群的 AD 研究合作进行荟萃分析。 亚裔美国人占美国人口的 6%，样本不足，值得进行更科学的调查 对阿尔茨海默病研究的投资。 ACAD 项目将建立第一个主要的 AD 遗传学研究 美国和加拿大的亚洲人。成功完成将带来新的基因和生活方式筛查标记 针对亚裔美国人的研究以及对 AD 新治疗靶点的见解。 ACAD 将成为第一个网络 在亚裔美国人中招募和研究AD，并将扩展到亚裔印度人、菲律宾人和其他亚裔人 未来的美国人口，满足亚洲阿尔茨海默病研究未满足的需求 美国人。

项目成果

Examine Race/Ethnicity Disparities in Perception, Intention, and Screening of Dementia in a Community Setting: Scoping Review.

• DOI: 10.3390/ijerph19148865
• 发表时间: 2022-07-21
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Lee, SangA;Kim, Deogwoon;Lee, Haeok
• 通讯作者: Lee, Haeok

Using community-based geographical information system (GIS) to recruit older Asian Americans in an Alzheimer's disease study.

• DOI: 10.1136/bmjopen-2023-072761
• 发表时间: 2023-08-03
• 期刊: BMJ OPEN
• 影响因子: 2.9
• 作者: Lee, Haeok;Ha, Hoehun;Yim, Sejung;Yang, Hyun-Sik;Lee, Veronica;Hong, Eunju;Chow, Tiffany W.;Park, Van Ta;Wang, Li-San;Jun, Gyungah;Choi, Yun-Beom
• 通讯作者: Choi, Yun-Beom

Ethnicity, Social, and Clinical Risk Factors to Tooth Loss among Older Adults in the U.S., NHANES 2011-2018.

• DOI: 10.3390/ijerph19042382
• 发表时间: 2022-02-18
• 期刊: International journal of environmental research and public health
• 作者: Lee H;Kim D;Jung A;Chae W
• 通讯作者: Chae W