Asian Cohort for Alzheimer's Disease (ACAD)

亚洲阿尔茨海默病队列 (ACAD)

基本信息

  • 批准号:
    10555689
  • 负责人:
  • 金额:
    $ 832.6万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-07-01 至 2028-06-30
  • 项目状态:
    未结题

项目摘要

Overall Abstract Alzheimer’s disease (AD) affects 5.8 million people in the United States and is an immense burden on our economy, patients and caregivers. Genome-wide association studies (GWAS) have successfully led to 25 genome-wide significant loci associated with AD risk and many more associations with key clinical covariates. Most of these findings are made on participants with European ancestry, although efforts to study other minority populations are taking off. Knowledge about AD genetics among Asian Americans is especially limited due to lack of participants. Comprising 6% of the US populace, Asian Americans are under-sampled and deserve more scientific investment. We propose the Asian Cohort for Alzheimer’s Disease (ACAD), the first large Alzheimer’s Disease (AD) genetics cohort for Asians in United States (US) and Canada. To address recruitment barriers, we assembled a team of scientists, clinicians, and community partners with collaborative history and expertise in AD research, human genetics, and Asian community outreach. We propose to recruit 5,081 participants aged 60 years or older and of Chinese, Korean, and Vietnamese ancestry from metropolitan areas across US and Canada in collaboration with community health providers or long-term care facilities that serve Asian communities. We will collect DNA and plasma biomarkers and use validated, translated data collection forms and clinical/diagnostic protocols. To support these recruitment and data collection activities, we will form six Cores that provide administrative oversite, outreach, clinical expertise, data management, biosample management, and training and quality assurance to support recruitment and analysis activities. All samples will be genotyped using SNP arrays and imputed using a large Asian-specific reference panel of whole genome sequencing data from international Asian cohorts. We propose two Research Projects that will analyze genetic, biomarker and clinical data to investigate impact of lifestyle risk factors, genetic variants for AD risk, evaluate differential effects of sex and APOE genotypes on AD risk, and predict clinical diagnosis of AD using genetic and lifestyle risk scores. We will replicate these findings through meta-analysis collaborations with international Asian cohorts and AD studies from other populations.
整体的抽象

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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HELENA Chang CHUI其他文献

HELENA Chang CHUI的其他文献

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{{ truncateString('HELENA Chang CHUI', 18)}}的其他基金

Quantitative cerebral blood vessel imaging biomarkers for AD and VCID
AD 和 VCID 的定量脑血管成像生物标志物
  • 批准号:
    10214060
  • 财政年份:
    2021
  • 资助金额:
    $ 832.6万
  • 项目类别:
Quantitative cerebral blood vessel imaging biomarkers for AD and VCID
AD 和 VCID 的定量脑血管成像生物标志物
  • 批准号:
    10721210
  • 财政年份:
    2021
  • 资助金额:
    $ 832.6万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    9922627
  • 财政年份:
    2020
  • 资助金额:
    $ 832.6万
  • 项目类别:
Alzheimer Disease Research Center
阿尔茨海默病研究中心
  • 批准号:
    10245804
  • 财政年份:
    2020
  • 资助金额:
    $ 832.6万
  • 项目类别:
Alzheimer Disease Research Center
阿尔茨海默病研究中心
  • 批准号:
    10641135
  • 财政年份:
    2020
  • 资助金额:
    $ 832.6万
  • 项目类别:
Alzheimer Disease Research Center
阿尔茨海默病研究中心
  • 批准号:
    10641166
  • 财政年份:
    2020
  • 资助金额:
    $ 832.6万
  • 项目类别:
USC ADRC Diversity Supplement - Guzman
南加州大学 ADRC 多样性补充 - 古兹曼
  • 批准号:
    10457217
  • 财政年份:
    2020
  • 资助金额:
    $ 832.6万
  • 项目类别:
Alzheimer Disease Research Center
阿尔茨海默病研究中心
  • 批准号:
    10655662
  • 财政年份:
    2020
  • 资助金额:
    $ 832.6万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10655663
  • 财政年份:
    2020
  • 资助金额:
    $ 832.6万
  • 项目类别:
Asian Cohort for Alzheimer's Disease (ACAD)
亚洲阿尔茨海默病队列 (ACAD)
  • 批准号:
    10263300
  • 财政年份:
    2020
  • 资助金额:
    $ 832.6万
  • 项目类别:

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