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Asian Cohort for Alzheimer's Disease (ACAD)

亚洲阿尔茨海默病队列 (ACAD)

基本信息

批准号：
10555689
负责人：
HELENA Chang CHUI
金额：
$ 832.6万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555689
关键词：
Address Advocacy Affect Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Alzheimer’s disease biomarker Area Asia Asian Asian Americans Asian population Awareness Biological Markers Biology Blood Blood specimen Canada Caregivers Categories Chinese Clinical Clinical Data Clinical Research Cognitive Collaborations Collection Communities Community Health Community Outreach Consensus DNA Data Data Collection Data Set Dementia Diagnosis Diagnostic Diet Disease Drug Targeting Etiology European ancestry Family Frequencies Funding Future Genetic Genetic Diseases Genetic Research Genetic study Genotype Gold Health Personnel Health care facility Hour Human Genetics Immigration Infrastructure International Investments Knowledge Koreans Language Leadership Life Experience Life Style Literature Long-Term Care Meta-Analysis Minority Groups Modeling Molecular Neurologic Neurology Participant Pathway interactions Patients Persons Physical activity Plasma Population Population Heterogeneity Procedures Protocols documentation Recording of previous events Research Research Project Grants Resources Risk Risk Factors SNP array Sampling Scientist Socioeconomic Status Staging Training Translating Translation Process United States Variant Vietnamese adjudication aged clinical predictors cohort community engagement data management data sharing effective therapy experience follow-up gene discovery genetic variant genome sequencing genome wide association study genome-wide geriatric depression health disparity improved insight metropolitan multi-ethnic new therapeutic target non-genetic outreach polygenic risk score precision medicine clinical trials prevent quality assurance recruit reference genome repository retention rate risk variant saliva sample screening sex synergism whole genome

项目摘要

Overall Abstract Alzheimer’s disease (AD) affects 5.8 million people in the United States and is an immense burden on our economy, patients and caregivers. Genome-wide association studies (GWAS) have successfully led to 25 genome-wide significant loci associated with AD risk and many more associations with key clinical covariates. Most of these findings are made on participants with European ancestry, although efforts to study other minority populations are taking off. Knowledge about AD genetics among Asian Americans is especially limited due to lack of participants. Comprising 6% of the US populace, Asian Americans are under-sampled and deserve more scientific investment. We propose the Asian Cohort for Alzheimer’s Disease (ACAD), the first large Alzheimer’s Disease (AD) genetics cohort for Asians in United States (US) and Canada. To address recruitment barriers, we assembled a team of scientists, clinicians, and community partners with collaborative history and expertise in AD research, human genetics, and Asian community outreach. We propose to recruit 5,081 participants aged 60 years or older and of Chinese, Korean, and Vietnamese ancestry from metropolitan areas across US and Canada in collaboration with community health providers or long-term care facilities that serve Asian communities. We will collect DNA and plasma biomarkers and use validated, translated data collection forms and clinical/diagnostic protocols. To support these recruitment and data collection activities, we will form six Cores that provide administrative oversite, outreach, clinical expertise, data management, biosample management, and training and quality assurance to support recruitment and analysis activities. All samples will be genotyped using SNP arrays and imputed using a large Asian-specific reference panel of whole genome sequencing data from international Asian cohorts. We propose two Research Projects that will analyze genetic, biomarker and clinical data to investigate impact of lifestyle risk factors, genetic variants for AD risk, evaluate differential effects of sex and APOE genotypes on AD risk, and predict clinical diagnosis of AD using genetic and lifestyle risk scores. We will replicate these findings through meta-analysis collaborations with international Asian cohorts and AD studies from other populations.

整体的抽象