Inflammatory Processes in Adolescent Girls with Primary Dysmenorrhea

项目摘要/摘要 原发痛经(PD)，或无明确病理的月经痛，已被证明是共同的 中枢神经系统的疼痛处理在行为和神经指标上都有缺陷。这些 改变可能会使一些女孩面临未来出现疼痛问题的风险，尽管表型分析显示 由于月经疼痛的女孩个体差异很大，帕金森病患者的“风险”群体一直具有挑战性。 最近的证据表明，免疫系统的失调可能是帕金森病的一个重要的生物标志物 这可能会揭示谁有慢性疼痛的风险。最近的一项研究表明，血浆水平上调 女性月经期间和月经后5天炎性细胞因子的遗传表达 有帕金森病的女性与没有帕金森病的女性相比。这些数据支持延长炎症反应时间的观点 可能是一个与从复发性疼痛向慢性疼痛过渡相关的表型生物标志物。 这份行政副刊的首要目标是“青春期女孩的炎症过程”。 《原发性痛经》旨在评估促炎细胞因子与疼痛的关系。 212名青春期女孩(年龄14-18岁)对不同程度月经疼痛的反应 没有使用任何外源激素。按照最初的建议，家长研究涉及所有参与者 接受疼痛敏感性的定量感觉测试(QST)以及结构和功能神经成像 注册时(基线)和一年后再次注册。此外，他们将每月被跟踪评估 月经疼痛和症状，以及非经期身体疼痛，总计两年(从注册开始)。 这项研究的发现将有助于描述炎症在这种高度流行的疾病中的作用。

Project Summary/Abstract Primary dysmenorrhea (PD), or menstrual pain without an identified pathology, has been shown to share deficits in pain processing in the central nervous system in both behavioral and neural indices. These alterations may put some girls at risk for the development of future pain problems, although phenotyping the “at risk” group with PD has been challenging due to significant individual variation among girls with menstrual pain. Recent evidence suggests that dysregulation of the immune system may be an important biomarker for PD that could shed light on who is at risk for chronic pain. One recent study demonstrated up-regulated plasma genetic expression of inflammatory cytokines during menstruation and 5 days following menstruation in women with PD compared to women without PD. These data support the idea that prolonged inflammatory responses may be a phenotypic biomarker associated with the transition from recurrent to chronic pain. The overarching objective of this administrative supplement, “Inflammatory Processes in Adolescent Girls with Primary Dysmenorrhea,” is to evaluate the relationship between pro-inflammatory cytokines and pain responses in a sample of 212 adolescent girls (ages 14-18 years) with varying levels of menstrual pain who are not using any exogenous hormones. As originally proposed, the parent study involves all participants receiving both quantitative sensory testing (QST) of pain sensitivity and structural and functional neuroimaging upon enrollment (baseline) and again one year later. Additionally, they will be followed monthly to assess menstrual pain and symptoms, as well as non-menstrual body pain, for two years total (from enrollment). Findings from the study will help characterize the role of inflammation in this highly prevalent condition.