An Oral (Gavage) Two-Generation Reproductive Toxicity Study of Eugenol in Rats (StudyNo. 01567001)

丁子香酚对大鼠的口服（灌胃）两代生殖毒性研究（研究编号：01567001）

• 批准号: 10458333
• 负责人: William J Brock
• 金额: $ 25万
• 依托单位: AQUI-S NEW ZEALAND, LTD
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10458333
• 关键词: Oral; Gavage; Two; Generation; Reproductive

An Oral (Gavage) Two-Generation Reproductive Toxicity Study of Eugenol in Rats (Study No. 01567001) Project Summary To evaluate the potential adverse effects of the test article on reproduction in a two-generation study. This will include determining the effects of the test article on male and female reproductive processes including gonadal function, estrous cyclicity, mating behavior, conception, gestation, parturition, lactation, weaning and on growth and development of the offspring. A minimum of one litter will be produced in each generation. In addition, the toxicokinetics of the test article will be examined during the study.

丁香酚大鼠口服(灌胃)两代生殖毒性研究(研究号： 01567001) 项目摘要 在一项两代人的研究中，评估测试品对生殖的潜在不良影响。 这将包括确定测试物品对男性和女性生殖过程的影响。 包括性腺功能、发情周期、交配行为、受孕、妊娠、分娩、 哺乳、断奶和对后代生长发育的影响。至少会有一窝 每一代都会产生。此外，测试物品的毒代动力学将在 这项研究。