Conduct of five data toxicity and toxicogenomics studies of brominated flame retardants in male rats treated via oral gavage for the NTP

对经口服 NTP 治疗的雄性大鼠进行五项溴化阻燃剂数据毒性和毒理基因组学研究

• 批准号: 9572821
• 负责人: BARNEY SPARROW
• 金额: $ 67.88万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2018-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9572821
• 关键词: Animals; Chemicals; Data; Data Analyses; Evaluation; Flame Retardants; Future; Genes; Goals; Human; Liver; Oral; Pathology; Pattern; Phase; Rattus; Reporting; Risk; Toxic effect; Toxicity Tests; Toxicogenomics; Transcript; hazard; male

The goals of this project are to characterize the toxicity of six “emerging” brominated flame retardants, to compare the toxicity and liver gene transcript patterns of these flame retardants to other compounds, and to provide data for prioritizing the need for future studies of the brominated flame retardants. These studies are in the pathology/data analysis/reporting phase. The NTP studies will provide valuable data to on a wide variety of endpoints to provide a thorough evaluation of potential hazards. Keywords: toxicity, brominated flame retardants, toxicogenomics.

该项目的目标是表征六种“新兴”经纪人阻燃剂的毒性，以比较这些火焰阻燃剂的毒性和肝基因转录物与其他化合物的毒性和肝脏基因转录本模式，并提供数据以优先考虑对溶解阻燃剂的未来研究的需求。这些研究处于病理/数据分析/报告阶段。 NTP研究将为各种端点提供有价值的数据，以提供对潜在危害的彻底评估。 关键字：毒性，溴化阻燃剂，毒性组学。