ICSC Core - Informatics

项目概要-核心/信息 ICSC信息学核心是NIH突变小鼠资源的信息技术支柱， 研究中心（MMRRC）。因此，信息学核心维护MMRRC网站和数据库， 提供所有通信服务，生成度量标准，并通过以下方式优化MMRRC营销工作 针对性分析。这是通过以下IT解决方案来实现的：[1]安全的MySQL关系数据库 该系统集中了与档案持有量、客户账户、采购/订单处理 和服务请求; [2] MMRRC文档的电子存档，以保护组织流程资产 (SOPs、政策）、报告和摘要（会议记录、指标报告）以及法律的协议（COU、MTA）; [3]一个专家策划的目录MMRRC持有与深注释信息的基因（S），等位基因（S），遗传 背景、命名法、唯一标识符、表型、出版物、许可信息、畜牧业、健康， 以及在方便的应变数据表中的可用性和定价; [4]数据跟踪和过程优化，以记录 任何一条记录上的所有信息，同时简化数据管理并消除数据质量风险; [5] MMRRC 指标系统，交互式可视化MMRRC性能方面的持有，订单，用户访问， 交通和外联活动响应;以及[6]内部和外部数据交换， 四个MMRRC中心之间的信息共享以及与远程权威数据库的联网 (e.g., PubMed、RRID、MGI、IMSR、Monarch、OMIMM等）。此外，信息学提供了所有 国际公务员制度委员会应用研究项目的方案编制和信息技术。因此，信息学核心， 负责所有与信息技术相关的开发、实施、扩展和维护移动、移动、移动和无线资源中心 作为研究社区的资源，严格遵守标准行业惯例，以增强数据 稳定和安全。信息学核心工作的成功得到了统计数据的支持：自2015年以来，MMRRC 在简化捐赠/订购流程后，其用户群（约50%）和持有量（约100%）大幅增加 以用户友好性为重点的处理。总之，信息学核心允许操作 卓越的研究社区已经开始期待从MMRRC作为一个生物研究社区资源 用于人类疾病病因学和干预的翻译研究。

PROJECT SUMMARY – CORE/INFORMATICS The ICSC Informatics Core is the information technology backbone of the NIH Mutant Mouse Resource and Research Centers (MMRRC). As such, the Informatics Core maintains the MMRRC website and databases, it provides all communication services, generates metrics, and it optimizes the MMRRC marketing effort through targeted analyses. This is accomplished with the following IT solutions: [1] a secure MySQL relational database that centralizes all information pertaining to archive holdings, customer accounts, acquisition/order processing, and service requests; [2] an electronic archive of MMRRC documents to secure organizational process assets (SOPs, policies), reports & summaries (meeting minutes, metric reports), and legal agreements (COUs, MTAs); [3] an expert-curated catalog of MMRRC holdings with deep-annotated information on gene(s), allele(s), genetic background, nomenclature, unique identifiers, phenotype, publications, licensing information, husbandry, health, as well as availability & pricing in convenient strain data sheets; [4] data tracking and process refinement to log all information on any one record while simplifying data curation and removing risks to data quality; [5] MMRRC metrics systems that interactively visualizes MMRRC performance in terms of holdings, orders, user access, traffic, and outreach campaign responses; and [6] internal and external data exchanges to enable efficient information sharing between the four MMRRC Centers as well as networking with remote authoritative databases (e.g., PubMed, RRID, MGI, IMSR, Monarch, OMIMM, etc.). The Informatics, furthermore, provides all programming and information technology for the ICSC Applied Research Project. The Informatics Core, hence, takes responsibility for all IT-related development, implementation, expansion, and maintenance of the MMRRC as a resource for the research community under strict adherence to standard industry practices to enhance data stability & security. The success of the Informatics Core efforts is backed by statistics: since 2015, the MMRRC enjoys formidable increases in its user base (~50%) and holdings (~100%) following streamlined donation/order processing with a focus on user-friendliness. In summary, the Informatics Core permits the operational excellence the research community has come to expect from the MMRRC as a bioresearch community resource for translational inquiries into human disease etiology and intervention.