Admin Core

项目摘要/摘要： 这篇P01的总体科学目标是了解前病毒和艾滋病毒的多样化格局- 在体内表达细胞的频率、存活/清除、与免疫反应的关系、 对免疫激活的贡献，细胞基因表达，组织特异性差异，对反弹的贡献， 以及对旨在治愈艾滋病毒的疗法的敏感性。为了帮助实现这一科学目标，行政部门 需要核心作为统一的中心，并提供领导、管理和组织。因此， 我们将建立一个行政核心，为所有3个组成部分的项目提供服务并拥有代表 和生物信息学核心。该管理核心将有三个与三个分支相对应的主要分支 主要目标：管理、资源分配和监控。在行政科内，该项目 协调员将组织每个项目/核心和整个P01的会议，以促进科学 相声相声，推动思想开放分享。资源处将有三个主要分司。 (临床、财务和数据资源)将管理临床样本的共享和分配、财务 所有项目和核心的资源和数据。监察处将由一名 执行委员会(由每个项目/核心的领导人组成)和一个外部科学咨询 委员会(包括与P01无关的独立调查人员)。这两个小组将发挥作用 共同跟踪和评估进展，确保问责，并发现问题和机会。使用 独立科学咨询委员会的投入，执行委员会将有权作出回应 应对新的挑战或机遇，并重新分配资源，以落实P01的总体目标。

Project summary/abstract: The overall scientific goal of this P01 is to understand how the diverse landscape of proviruses and HIV- expressing cells in vivo differ in their frequency, survival/clearance, relationship to immune responses, contribution to immune activation, cellular gene expression, tissue specific differences, contribution to rebound, and susceptibility to therapies aimed at HIV cure. To help implement this scientific goal, an Administrative Core is needed to serve as a unifying center and provide leadership, management, and organization. Therefore, we will establish an Administrative Core that will serve and have representatives from all 3 component projects and the Bioinformatics Core. This Administrative Core will have three main branches corresponding to the three main aims: Administration, Resource Allocation, and Monitoring. Within the AdministrativeBranch,the Project Coordinator will organize meetings of each project/core and the entire P01 in order to facilitate scientific crosstalk and promote the open sharing of ideas. The Resources Branch will have three main subdivisions (Clinical, Financial, and Data Resources) that will manage the sharing and allocation of clinical samples, financial resources, and data across all of the projects and cores. The Monitoring Branch will be comprised of an Executive Committee (composed of the leaders of each project/core) and an external Scientific Advisory Board (containing independent investigators who are not involved in the P01). These two groups will work together to track and evaluate progress, ensure accountability, and identify problems and opportunities. With input from the independent Scientific Advisory Board, the Executive Committee will be empowered to respond to new challenges or opportunities and reallocate resources in order to implement the overall goals of the P01.