Admin Core

管理核心

• 批准号: 10614009
• 负责人: Steven A Yukl
• 金额: $ 13.78万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614009
• 关键词: Accountability; Binding; Bioinformatics; Cells; Clinical; Collaborations; Communication; Communities; Contracts; Data; Drug or chemical Tissue Distribution; Ensure; Evaluation; Fostering; Frequencies; Goals; Grant; HIV; Immune response; Individual; Leadership; Monitor; Phenotype; Predisposition; Productivity; Proteins; Proviruses; Quality Control; RNA; Research Personnel; Resource Allocation; Resources; Sampling; Sum; Tissue-Specific Gene Expression; Vision; Work; cohort; data resource; data sharing; empowerment; immune activation; in vivo; meetings; member; organizational structure; sound; synergism

Project summary/abstract: The overall scientific goal of this P01 is to understand how the diverse landscape of proviruses and HIV- expressing cells in vivo differ in their frequency, survival/clearance, relationship to immune responses, contribution to immune activation, cellular gene expression, tissue specific differences, contribution to rebound, and susceptibility to therapies aimed at HIV cure. To help implement this scientific goal, an Administrative Core is needed to serve as a unifying center and provide leadership, management, and organization. Therefore, we will establish an Administrative Core that will serve and have representatives from all 3 component projects and the Bioinformatics Core. This Administrative Core will have three main branches corresponding to the three main aims: Administration, Resource Allocation, and Monitoring. Within the AdministrativeBranch,the Project Coordinator will organize meetings of each project/core and the entire P01 in order to facilitate scientific crosstalk and promote the open sharing of ideas. The Resources Branch will have three main subdivisions (Clinical, Financial, and Data Resources) that will manage the sharing and allocation of clinical samples, financial resources, and data across all of the projects and cores. The Monitoring Branch will be comprised of an Executive Committee (composed of the leaders of each project/core) and an external Scientific Advisory Board (containing independent investigators who are not involved in the P01). These two groups will work together to track and evaluate progress, ensure accountability, and identify problems and opportunities. With input from the independent Scientific Advisory Board, the Executive Committee will be empowered to respond to new challenges or opportunities and reallocate resources in order to implement the overall goals of the P01.

项目总结/摘要： 本P01的总体科学目标是了解前病毒和HIV的多样性是如何- 体内表达细胞在其频率、存活/清除，与免疫应答的关系， 对免疫激活的贡献，细胞基因表达，组织特异性差异，对反弹的贡献， 以及对艾滋病治疗的敏感性。为了帮助实现这一科学目标， 核心需要作为一个统一的中心，并提供领导，管理和组织。因此，我们认为， 我们将建立一个行政核心，该核心将为所有3个组成项目提供服务，并有其代表 和生物信息学核心这个行政核心将有三个主要分支， 主要目标：管理、资源分配和监测。在行政部门内， 协调员将组织每个项目/核心和整个P01的会议， 串话，促进思想的开放共享。资源分支将有三个主要分支 （临床、财务和数据资源），将管理临床样本的共享和分配，财务 资源和数据。监测分支将由 执行委员会（由每个项目/核心的领导人组成）和外部科学顾问 委员会（包含不参与P01的独立研究者）。这两个小组将工作 共同跟踪和评估进展，确保问责制，并确定问题和机会。与 独立的科学咨询委员会的意见，执行委员会将有权作出回应， 应对新的挑战或机遇，重新分配资源，以实现P01的总体目标。