Brain Bank Core

大脑银行核心(BBC)的总体目标是开展和促进对RHI和TBI的研究 并确定与AD、ADRD、CTE和其他神经退行性病理以及临床的相关性 结果。BBC将包括8个脑库队列，其中6个来自波士顿大学医学院(BUSM) 和退伍军人事务部波士顿医疗系统：弗吉尼亚大学阿尔茨海默病中心(BUADC)，弗雷明翰心脏 研究(FHS)，退伍军人创伤后应激障碍(PTSD)，退伍军人肌萎缩侧索硬化症(ALS)，慢性 神经创伤(CENC)和联合的VA-BU-CLF(联合)和2来自伊坎医学院在蒙特的效果 西奈半岛(ISMMS)系统地评估RHI和脑外伤相关的精确神经病理 神经退行性变。这些组合的脑库包含超过2500个案例，其中包括最大的 世界上361例经神经病理证实的CTE受试者尸检队列。此外，LETBI， CENC、ALS和联合脑库至少保存了50例远程、中重度脑损伤合并慢性脑损伤 空洞性病变(CTBI)。BBC的具体目标包括基本的核心职能，即履行 最先进的诊断神经病理学，以最佳方式存储和分发CNS组织和其他生物显微镜， 并为项目1-3和联邦机构间创伤性脑损伤提供神经病理学数据 面向普通科学界的研究(FITBIR)。所有的神经病理方案都将与 由NINDS神经病理CTE共识会议提出的生物样品收集建议， 封堵、染色和储存，这是PI领导和帮助建立的。此外，还建立了一个数字图书馆 将为每个参与者制作病理幻灯片，并向公众提供。最后，英国广播公司将发挥作用 开发评估RHI和cTBI相关损伤的新方法，包括轴突和白质 变性、胶质增生症和炎症。具体目标也建立在PI的重大创新之上 和研究人员关于RHI，cTBI和CTE的研究，并专注于确定病理和临床 脑部撞击和损伤后的联系。为了实现这些目标，英国广播公司将密切合作 与行政当局、数据核心和项目1-3以及相关的ISMMS进行协作 阿尔茨海默氏症和研究中心、脑库和BUADC。总体而言，BBC将提供一个 协调神经病理检查和评估，以便利储存和分发 生物检疫、综合诊断、数字图书馆的创建和新型定量研究的发展 神经病理学措施，以最好地捕捉RHI和脑外伤的慢性后遗症。标本和 BBC收集的数据将与项目1-协调临床中确定的RHI和TBI病史相关联 项目2中评估的结果，以及项目中确定的其他病理和炎症措施 3.统一数据将在项目1-3中广泛使用，并向外部广泛提供 调查人员。

The overarching goals of the Brain Banking Core (BBC) are to conduct and foster research on RHI and TBI and to determine associations with AD, ADRD, CTE, and other neurodegenerative pathology as well as clinical outcomes. The BBC will include 8 brain bank cohorts, 6 from Boston University School of Medicine (BUSM) and the VA Boston Healthcare System: the BU Alzheimer Disease Center (BUADC), Framingham Heart Study (FHS), VA Post-Traumatic Stress Disorder (PTSD), VA amyotrophic lateral sclerosis (ALS), Chronic Effects of Neurotrauma (CENC) and VA-BU-CLF (UNITE) and 2 from the Icahn School of Medicine at Mount Sinai (ISMMS) to systematically evaluate the precise neuropathology of RHI and TBI-related neurodegeneration. These combined brain banks contain over 2500 cases, and include the largest neuropathologically confirmed autopsy cohort of CTE subjects (n= 361) in the world. In addition, the LETBI, CENC, ALS, and UNITE brain banks hold at least 50 cases of remote, moderately-severe TBI with a chronic cavitary lesion (cTBI). The specific aims of the BBC consist of fundamental Core functions, namely to perform state-of-the-art diagnostic neuropathology, optimally store and distribute CNS tissue and other biospecimens, and provide neuropathological data for Projects 1-3 and to the Federal Interagency Traumatic Brain Injury Research (FITBIR) for the general scientific community. All neuropathological protocols will be aligned with those proposed by the NINDS Neuropathological CTE Consensus Conference for biospecimen collection, blocking, staining and storage, which the PI led and helped establish. In addition, a digital library of the pathology slides will be generated for each participant and made publicly available. Finally, the BBC will work to develop novel methods for the assessment of RHI and cTBI-related injury to include axonal and white matter degeneration, gliosis, and inflammation. The specific aims also build upon the significant innovations of the PI and investigators with regard to RHI, cTBI, and CTE and focus on determining the pathological and clinical associations following brain impacts and injury. To accomplish these aims, the BBC will work in close collaboration with the Administration and Data Cores and Projects 1-3, as well as the associated ISMMS Alzheimer's Disease and Research Center Brain Bank and the BUADC. Overall, the BBC will provide a harmonized neuropathological workup and assessment in order to facilitate the storage and distribution of biospecimens, comprehensive diagnoses, digital library creation, and the development of novel quantitative neuropathological measures in order to best capture the chronic sequalae of RHI and TBI. Specimens and data collected by the BBC will be linked to RHI and TBI history determined in Project 1, harmonized clinical outcomes assessed in Project 2, and additional pathological and inflammatory measures determined in Project 3. The harmonized data will be used extensively across Projects 1-3 and made widely available for outside investigators.