Molecular and Translational Imaging Core Facility Shared Resource

分子和转化成像核心设施共享资源

• 批准号: 10460191
• 负责人: Dong-Hyun Kim
• 金额: $ 15.96万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10460191
• 关键词: Animal Model; Antineoplastic Agents; Biological Sciences; Cancer Center; Cancer Center Support Grant; Cells; Chicago; Clinical; Clinical Research; Collaborations; Comprehensive Cancer Center; Computer software; Core Facility; Development; Developmental Therapeutics Program; Equipment; Flow Cytometry; Funding; Goals; Grant; Histologic; Histology; Image; Image Analysis; Imaging technology; Individual; Isotope Labeling; Label; Magnetic Resonance Imaging; Malignant Neoplasms; Medical Imaging; Methods; Modality; Molecular; Multimodal Imaging; Mus; Near-infrared optical imaging; Neoplasm Metastasis; Outcome Study; PET/CT scan; Patient Care; Peer Review; Phenotype; Production; Radiochemistry; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Schedule; Services; Site; Technology; Testing; Therapeutic Agents; Universities; Validation; Work; anticancer research; cell behavior; clinical imaging; data analysis pipeline; efficacy evaluation; image processing; imaging approach; imaging capabilities; imaging modality; imaging study; improved; in vivo; instrumentation; member; non-invasive monitor; novel diagnostics; novel strategies; novel therapeutics; nuclear imaging; pre-clinical; preclinical imaging; preclinical study; single photon emission computed tomography; tool; tumor growth

ABSTRACT – MOLECULAR AND TRANSLATIONAL IMAGING CORE The Molecular and Translational Imaging Core (MTIC) provides Lurie Cancer Center (LCC) members with multi- modal imaging capabilities that support their cancer research by enabling users to apply advanced imaging technologies to their preclinical and clinical studies. The ability to track injected or engrafted cells, administered agents, and tumor growth and metastasis in a non-invasive fashion is an invaluable tool in the development and testing of new diagnostic and therapeutic agents that can improve patient care. The MTIC has sites on both the Evanston and Chicago campuses. Instrumentation that is available to users at one or both sites includes MRI, PET/CT, SPECT/CT, and IVIS (fluorescent, bioluminescent and near infrared optical imaging). The MTIC provides expert staff in each of these modalities and allows investigators to apply the most appropriate imaging methods to their cancer studies. The MTIC collaborates closely with other LCC core facilities, including the Developmental Therapeutics Core, the Flow Cytometry Core, and the Mouse Histology and Phenotyping Core. During the most recent reporting period, MTIC scientific and technical staff provided support to 45 LCC users, 43 of whom had peer-reviewed funding. The scheduled installation of a radiochemistry production facility on the Chicago campus, and plans by the MTIC to offer additional, state-of- the-art imaging modalities during the next CCSG cycle, will further increase the value of this facility to Lurie Cancer Center members.

摘要-分子和平移成像核心 分子和翻译成像核心（MTIC）为Lurie癌症中心（LCC）成员提供多项 模态成像功能，使用户能够应用先进的成像技术， 临床前和临床研究的技术。追踪注射或移植的细胞的能力， 药物和肿瘤生长和转移的非侵入性方式是一个宝贵的工具，在发展和 测试新的诊断和治疗剂，可以改善病人的护理。 MTIC在埃文斯顿和芝加哥校区都有网站。用户可在以下位置使用的工具： 一个或两个部位包括MRI、PET/CT、SPECT/CT和IVIS（荧光、生物发光和近红外 光学成像）。MTIC为每种模式提供专家工作人员，并允许调查人员申请 最适合他们癌症研究的成像方法。MTIC与其他LCC密切合作 核心设施，包括发育治疗学核心、流式细胞术核心和小鼠 组织学和表型核心。在最近的报告所述期间，MTIC的科学和技术工作人员 向45个地方合同委员会用户提供了支助，其中43个用户获得了同行审查的资金。计划安装的 放射化学生产设施的芝加哥校园，并计划由MTIC提供额外的，国家的， 在下一个CCSG周期中，最先进的成像模式将进一步增加该设施对Lurie的价值 癌症中心成员。