Molecular and Translational Imaging Core Facility Shared Resource

抽象分子与平移成像核 分子和翻译成像核心(MTIC)为Lurie癌症中心(LCC)成员提供多个 通过使用户能够应用高级成像来支持其癌症研究的模式成像功能 为他们的临床前和临床研究提供技术支持。追踪注射或移植细胞的能力 药物和非侵入性方式的肿瘤生长和转移是开发和 测试新的诊断和治疗药物，以改善患者护理。 MTIC在埃文斯顿和芝加哥校区都设有分校。用户可通过以下地址获取工具： 一个或两个站点包括MRI、PET/CT、SPECT/CT和IVIS(荧光、生物发光和近红外 光学成像)。MTIC提供了每种模式的专家工作人员，并允许调查人员申请 最适合他们癌症研究的成像方法。MTIC与其他LCC密切合作 核心设施，包括发育治疗核心、流式细胞仪核心和小鼠 组织学和表型核心。在最近一次报告所述期间，MTIC科学和技术人员 向45名LCC用户提供了支持，其中43人获得了同行审查的资金。按计划安装 位于芝加哥园区的放射化学生产设施，并计划由MTIC提供额外的、最先进的- 在下一个CCSG周期中，最先进的成像设备将进一步提高该设备对Lurie的价值 癌症中心成员。

ABSTRACT – MOLECULAR AND TRANSLATIONAL IMAGING CORE The Molecular and Translational Imaging Core (MTIC) provides Lurie Cancer Center (LCC) members with multi- modal imaging capabilities that support their cancer research by enabling users to apply advanced imaging technologies to their preclinical and clinical studies. The ability to track injected or engrafted cells, administered agents, and tumor growth and metastasis in a non-invasive fashion is an invaluable tool in the development and testing of new diagnostic and therapeutic agents that can improve patient care. The MTIC has sites on both the Evanston and Chicago campuses. Instrumentation that is available to users at one or both sites includes MRI, PET/CT, SPECT/CT, and IVIS (fluorescent, bioluminescent and near infrared optical imaging). The MTIC provides expert staff in each of these modalities and allows investigators to apply the most appropriate imaging methods to their cancer studies. The MTIC collaborates closely with other LCC core facilities, including the Developmental Therapeutics Core, the Flow Cytometry Core, and the Mouse Histology and Phenotyping Core. During the most recent reporting period, MTIC scientific and technical staff provided support to 45 LCC users, 43 of whom had peer-reviewed funding. The scheduled installation of a radiochemistry production facility on the Chicago campus, and plans by the MTIC to offer additional, state-of- the-art imaging modalities during the next CCSG cycle, will further increase the value of this facility to Lurie Cancer Center members.