Targeted Transcatheter Magneto-Mechanical Therapy for Hepatocellular Carcinoma
肝细胞癌的靶向经导管磁力机械治疗
基本信息
- 批准号:8704901
- 负责人:
- 金额:$ 19.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-08-01 至 2016-01-31
- 项目状态:已结题
- 来源:
- 关键词:AddressApoptosisApoptoticAutopsyBindingBiomedical EngineeringCD44 geneCaliberCancer BiologyCell DeathCell SurvivalCell membraneCellsCharacteristicsDataFunctional Magnetic Resonance ImagingHepaticHepatic arteryImageImaging PhantomsImaging TechniquesIn VitroInfusion proceduresInjection of therapeutic agentMagnetic Resonance ImagingMagnetismMalignant Epithelial CellMalignant NeoplasmsMeasurementMeasuresMechanicsMethodsModelingMonitorMonitoring for RecurrenceMotionNecrosisPalliative CarePatientsPrimary carcinoma of the liver cellsQuantitative MicroscopyRadiology SpecialtyRattusRecurrenceRelaxationRodent ModelSchemeSolid NeoplasmSurfaceTechniquesTherapeuticTumor BurdenTumor TissueTumor VolumeUnresectableValidationVascular blood supplycancer cellcancer therapydosageeffective therapyfollow-uphepatoma cellimprovedin vivoinnovationmagnetic fieldnanodisknanomagneticnanosizedneoplastic cellnovel therapeuticsoutcome forecastparticlepublic health relevanceresponsetumor
项目摘要
DESCRIPTION (provided by applicant): The broad, long-term objective of this proposal is to improve the prognosis of patients with unresectable hepatocellular carcinoma (HCC). Current therapies are palliative and relatively ineffective for improving prognosis. There exists a critica need for improved methods for effective treatment. Our recent studies have demonstrated the exciting potential of an innovative new therapeutic option for solid tumors; our proposed approach involves using magnetic vortex disks that apply magneto-mechanical forces at the surface of targeted cell membranes to induce apoptotic cell death. We propose the first in vivo study to validate the anti-cancer efficacy of magneto-mechanical therapy for the treatment of HCC. Magnetic nanodisks will be fabricated and characterized for magneto-mechanical cell destruction. We will use transcatheter infusions to deliver the magnetic disks directly into the blood supply of the targeted hepatic tumors. In vivo targeting efficiency via transcatheter hepatic
artery injection will be studied with MRI quantification and histological measurements in an HCC rat model. Finally, we will evaluate in vivo therapeutic responses of targeted transcatheter magneto-mechanical cancer therapy; we will validate the ability to induce apoptotic HCC cell death using anti-CD44 conjugated magnetic nanodisks in the rodent model. Through a collaborative project building upon our strengths in biomedical engineering, radiology, and cancer biology, we seek to develop a powerful new magneto-mechanical therapeutic method for the treatment of HCC. Our proposed project will address the following Specific Aims: Aim 1: To determine targeting efficiency and imaging characteristics of our nano magnetic disks Task 1.1: To fabricate various nano-sized magnetic spin-vortex disks (Au coated Fe disk) at a specific geometrical ratio for magneto-mechanical motion upon cell membrane. Task 1.2: Biofunctionalization of magnetic disks and validation of in vitro magneto-mechanical destruction of hepatocellular carcinoma cells. Task 1.3: To characterize relationship between magnetic nanodisks concentration and T2/T2* relaxations rates for magnetic resonance imaging (MRI). Aim 2: To validate that transcatheter magneto-mechanical cancer therapy leads to tumor regression in HCC rat models. Task 2.1: To determine in vivo targeting efficiency of magnetic nanodisks using both in vivo quantitative MRI measurements and invasive histological measurements at necropsy. Task 2.2. To demonstrate in vivo therapeutic responses to targeted transcatheter magneto-mechanical therapy with both functional MRI technique and pathological analysis of tumor cell death.
描述(由申请人提供):本提案的广泛、长期目标是改善不可切除肝细胞癌(HCC)患者的预后。目前的治疗是姑息性的,对改善预后相对无效。迫切需要改进有效治疗的方法。我们最近的研究已经证明了一种创新的治疗实体瘤的新选择的令人兴奋的潜力;我们提出的方法包括使用磁旋涡盘在靶细胞膜表面施加磁机械力来诱导凋亡细胞死亡。我们提出了第一个体内研究来验证磁机械治疗肝癌的抗癌功效。磁性纳米片将被制造和表征为磁机械细胞破坏。我们将使用经导管输注将磁盘直接送入目标肝脏肿瘤的血液供应中。经肝导管的体内靶向效率
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Dong-Hyun Kim其他文献
Dong-Hyun Kim的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Dong-Hyun Kim', 18)}}的其他基金
Local Tumoral Delivered Immune Checkpoint Blockades Immunotherapy and Radioembolization Combination Therapy
局部肿瘤传递的免疫检查点阻断免疫疗法和放射栓塞联合疗法
- 批准号:
10718531 - 财政年份:2023
- 资助金额:
$ 19.56万 - 项目类别:
Image-Guided Transcatheter Delivery of Natural Killer Cell Therapy Augmented with IFN-Gamma Eluting Microspheres
图像引导经导管递送自然杀伤细胞疗法,增强 IFN-γ 洗脱微球
- 批准号:
9766289 - 财政年份:2018
- 资助金额:
$ 19.56万 - 项目类别:
Image-Guided Transcatheter Delivery of Natural Killer Cell Therapy Augmented with IFN-Gamma Eluting Microspheres
图像引导经导管递送自然杀伤细胞疗法,增强 IFN-γ 洗脱微球
- 批准号:
10176483 - 财政年份:2018
- 资助金额:
$ 19.56万 - 项目类别:
Catheter-Directed Image-Guided Delivery of Cytostatic and Cytotoxic Combination Therapy to Liver Tumors
导管引导图像引导对肝脏肿瘤进行细胞抑制和细胞毒性联合治疗
- 批准号:
10377409 - 财政年份:2018
- 资助金额:
$ 19.56万 - 项目类别:
Catheter-Directed Image-Guided Delivery of Cytostatic and Cytotoxic Combination Therapy to Liver Tumors
导管引导图像引导对肝脏肿瘤进行细胞抑制和细胞毒性联合治疗
- 批准号:
9894760 - 财政年份:2018
- 资助金额:
$ 19.56万 - 项目类别:
Catheter-Directed Image-Guided Delivery of Cytostatic and Cytotoxic Combination Therapy to Liver Tumors
导管引导图像引导对肝脏肿瘤进行细胞抑制和细胞毒性联合治疗
- 批准号:
10165661 - 财政年份:2018
- 资助金额:
$ 19.56万 - 项目类别:
Magnetic Nanocomposites for Catheter-Directed Drug Delivery to Liver Tumors
用于肝肿瘤导管定向药物输送的磁性纳米复合材料
- 批准号:
8624410 - 财政年份:2014
- 资助金额:
$ 19.56万 - 项目类别:
Targeted Transcatheter Magneto-Mechanical Therapy for Hepatocellular Carcinoma
肝细胞癌的靶向经导管磁力机械治疗
- 批准号:
8584047 - 财政年份:2013
- 资助金额:
$ 19.56万 - 项目类别:
Molecular and Translational Imaging Core Facility Shared Resource
分子和转化成像核心设施共享资源
- 批准号:
10460191 - 财政年份:1997
- 资助金额:
$ 19.56万 - 项目类别:
Molecular and Translational Imaging Core Facility Shared Resource
分子和转化成像核心设施共享资源
- 批准号:
10902182 - 财政年份:1997
- 资助金额:
$ 19.56万 - 项目类别:
相似国自然基金
Epac1/2通过蛋白酶体调控中性粒细胞NETosis和Apoptosis在急性肺损伤中的作用研究
- 批准号:LBY21H010001
- 批准年份:2020
- 资助金额:0.0 万元
- 项目类别:省市级项目
基于Apoptosis/Ferroptosis双重激活效应的天然产物AlbiziabiosideA的抗肿瘤作用机制研究及其结构改造
- 批准号:81703335
- 批准年份:2017
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
双肝移植后Apoptosis和pyroptosis在移植物萎缩差异中的作用和供受者免疫微环境变化研究
- 批准号:81670594
- 批准年份:2016
- 资助金额:58.0 万元
- 项目类别:面上项目
Serp-2 调控apoptosis和pyroptosis 对肝脏缺血再灌注损伤的保护作用研究
- 批准号:81470791
- 批准年份:2014
- 资助金额:73.0 万元
- 项目类别:面上项目
Apoptosis signal-regulating kinase 1是七氟烷抑制小胶质细胞活化的关键分子靶点?
- 批准号:81301123
- 批准年份:2013
- 资助金额:23.0 万元
- 项目类别:青年科学基金项目
APO-miR(multi-targeting apoptosis-regulatory miRNA)在前列腺癌中的表达和作用
- 批准号:81101529
- 批准年份:2011
- 资助金额:22.0 万元
- 项目类别:青年科学基金项目
放疗与细胞程序性死亡(APOPTOSIS)相关性及其应用研究
- 批准号:39500043
- 批准年份:1995
- 资助金额:9.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Spatial Restriction of Apoptotic Machinery during Neuronal Apoptosis and Pruning
神经元凋亡和修剪过程中凋亡机制的空间限制
- 批准号:
10596657 - 财政年份:2021
- 资助金额:
$ 19.56万 - 项目类别:
Spatial Restriction of Apoptotic Machinery during Neuronal Apoptosis and Pruning
神经元凋亡和修剪过程中凋亡机制的空间限制
- 批准号:
10417219 - 财政年份:2021
- 资助金额:
$ 19.56万 - 项目类别:
Examining the contribution of apoptosis repressor with caspase recruitment domain (ARC) to the anti-apoptotic effect of endurance training in skeletal muscle
检查具有半胱天冬酶募集结构域 (ARC) 的凋亡抑制因子对骨骼肌耐力训练的抗凋亡作用的贡献
- 批准号:
441952-2013 - 财政年份:2015
- 资助金额:
$ 19.56万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Examining the contribution of apoptosis repressor with caspase recruitment domain (ARC) to the anti-apoptotic effect of endurance training in skeletal muscle
检查具有半胱天冬酶募集结构域 (ARC) 的凋亡抑制因子对骨骼肌耐力训练的抗凋亡作用的贡献
- 批准号:
441952-2013 - 财政年份:2014
- 资助金额:
$ 19.56万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Understanding the activation of pro-apoptotic Bcl-2 family proteins for the development of modulators of apoptosis
了解促凋亡 Bcl-2 家族蛋白的激活以开发凋亡调节剂
- 批准号:
nhmrc : 1059331 - 财政年份:2014
- 资助金额:
$ 19.56万 - 项目类别:
Project Grants
Examining the contribution of apoptosis repressor with caspase recruitment domain (ARC) to the anti-apoptotic effect of endurance training in skeletal muscle
检查具有半胱天冬酶募集结构域 (ARC) 的凋亡抑制因子对骨骼肌耐力训练的抗凋亡作用的贡献
- 批准号:
441952-2013 - 财政年份:2013
- 资助金额:
$ 19.56万 - 项目类别:
Postgraduate Scholarships - Doctoral
Apoptotic Osteocytes Promote Chondrocyte Apoptosis via Soluble Factors
凋亡骨细胞通过可溶性因子促进软骨细胞凋亡
- 批准号:
251802 - 财政年份:2012
- 资助金额:
$ 19.56万 - 项目类别:
Studentship Programs
Defining the mechanism(s) by which the cellular inhibitor of apoptosis protein 2 (cIAP2) contributes to early stage atherosclerosis development by directly promoting the participation of key apoptotic pathways within lesion-associated macrophages
确定凋亡蛋白细胞抑制剂 2 (cIAP2) 通过直接促进病变相关巨噬细胞内关键凋亡途径的参与来促进早期动脉粥样硬化发展的机制
- 批准号:
191299 - 财政年份:2009
- 资助金额:
$ 19.56万 - 项目类别:
Operating Grants
ATP release during apoptosis and its relevance to apoptotic cell clearance
凋亡过程中 ATP 释放及其与凋亡细胞清除的相关性
- 批准号:
8075522 - 财政年份:2009
- 资助金额:
$ 19.56万 - 项目类别:
ATP release during apoptosis and its relevance to apoptotic cell clearance
凋亡过程中 ATP 释放及其与凋亡细胞清除的相关性
- 批准号:
7676912 - 财政年份:2009
- 资助金额:
$ 19.56万 - 项目类别: