Molecular and Translational Imaging Core Facility Shared Resource

分子和转化成像核心设施共享资源

• 批准号: 10902182
• 负责人: Dong-Hyun Kim
• 金额: $ 17.9万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10902182
• 关键词: Animal Model; Antineoplastic Agents; Biological Sciences; Cancer Center; Cancer Center Support Grant; Cells; Chicago; Clinical; Clinical Research; Collaborations; Comprehensive Cancer Center; Computer software; Core Facility; Development; Developmental Therapeutics Program; Engraftment; Equipment; Flow Cytometry; Funding; Goals; Grant; Histologic; Histology; Image; Image Analysis; Imaging technology; Individual; Isotope Labeling; Label; Magnetic Resonance Imaging; Malignant Neoplasms; Medical Imaging; Methods; Modality; Molecular; Multimodal Imaging; Mus; Near-infrared optical imaging; Neoplasm Metastasis; Outcome Study; PET/CT scan; Patient Care; Peer Review; Phenotype; Production; Radiochemistry; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Schedule; Services; Site; Sorting; Technology; Testing; Therapeutic Agents; Universities; Validation; Work; anticancer research; cell behavior; clinical imaging; data analysis pipeline; efficacy evaluation; image processing; image translation; imaging approach; imaging capabilities; imaging modality; imaging study; improved; in vivo; instrumentation; member; non-invasive monitor; novel diagnostics; novel strategies; novel therapeutics; nuclear imaging; pre-clinical; preclinical imaging; preclinical study; single photon emission computed tomography; tool; tumor growth

ABSTRACT – MOLECULAR AND TRANSLATIONAL IMAGING CORE The Molecular and Translational Imaging Core (MTIC) provides Lurie Cancer Center (LCC) members with multi- modal imaging capabilities that support their cancer research by enabling users to apply advanced imaging technologies to their preclinical and clinical studies. The ability to track injected or engrafted cells, administered agents, and tumor growth and metastasis in a non-invasive fashion is an invaluable tool in the development and testing of new diagnostic and therapeutic agents that can improve patient care. The MTIC has sites on both the Evanston and Chicago campuses. Instrumentation that is available to users at one or both sites includes MRI, PET/CT, SPECT/CT, and IVIS (fluorescent, bioluminescent and near infrared optical imaging). The MTIC provides expert staff in each of these modalities and allows investigators to apply the most appropriate imaging methods to their cancer studies. The MTIC collaborates closely with other LCC core facilities, including the Developmental Therapeutics Core, the Flow Cytometry Core, and the Mouse Histology and Phenotyping Core. During the most recent reporting period, MTIC scientific and technical staff provided support to 45 LCC users, 43 of whom had peer-reviewed funding. The scheduled installation of a radiochemistry production facility on the Chicago campus, and plans by the MTIC to offer additional, state-of- the-art imaging modalities during the next CCSG cycle, will further increase the value of this facility to Lurie Cancer Center members.

摘要 – 分子和翻译成像核心 分子和转化成像核心 (MTIC) 为卢里癌症中心 (LCC) 成员提供多种 模态成像功能，通过使用户能够应用先进的成像来支持他们的癌症研究 技术应用于临床前和临床研究。追踪注射或移植细胞的能力 以非侵入性方式进行肿瘤生长和转移是发展和转移过程中的宝贵工具。 测试可以改善患者护理的新诊断和治疗药物。 MTIC 在埃文斯顿校区和芝加哥校区均设有站点。用户可以使用的仪器 一个或两个站点包括 MRI、PET/CT、SPECT/CT 和 IVIS（荧光、生物发光和近红外） 光学成像）。 MTIC 为每种模式提供专家人员，并允许研究人员申请 最适合其癌症研究的成像方法。 MTIC 与其他低成本航空公司密切合作 核心设施，包括发育治疗核心、流式细胞术核心和小鼠 组织学和表型核心。在最近的报告期内，MTIC 科学和技术人员 为 45 个 LCC 用户提供了支持，其中 43 个用户获得了同行评审的资金。预定的安装 芝加哥园区的放射化学生产设施，并计划由 MTIC 提供额外的、最先进的 下一个 CCSG 周期中最先进的成像模式将进一步增加该设施对 Lurie 的价值 癌症中心成员。