Sex and Gender Analysis Resource Core

性与性别分析资源核心

• 批准号: 10460500
• 负责人: Rosemary Morgan
• 金额: $ 24.23万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10460500
• 关键词: Adult; Adverse reactions; Age; Clinical; Clinical Research; Collection; Data; Data Analyses; Data Collection; Ensure; Fostering; Gender; Goals; Health; Human; Immune response; Immunity; Immunologics; Influenza; Influenza vaccination; Institution; Outcome; Principal Investigator; Procedures; Process; Protocols documentation; Public Health; Race; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Rosemary; Services; Sex Differences; Universities; Vaccination; Vaccines; Woman; adverse outcome; age difference; aged; frailty; gender difference; improved; influenza virus vaccine; interest; men; programs; sex; social; tool; vaccine acceptance

SEX AND AGE DIFFERENCES IN IMMUNITY TO INFLUENZA (SADII) SEX AND GENDER ANALYSIS RESOURCE CORE SUMMARY The SADII Sex and Gender Analysis Core will be led by Drs. Rosemary Morgan and Abdul Bachani and will provide analytic support to the human research projects (i.e., SADII Research Projects 1 and 2) included under the SADII SCORE. The Core will provide input into the data collection tools and approaches utilized in SADII Research Projects 1 and 2 to better inform relevant sex and gender analysis, in addition to providing support for both qualitative and quantitative analyses of data to examine and understand the distinct and overlapping contributions of sex and gender, and their intersection with other social stratifiers (e.g., race), to vaccine- induced immune responses, adverse reactions, and outcomes in young and aged adults. Specifically, we will explore sex and gender differences in: (1) influenza vaccine acceptance (SADII Research Project 2); (2) immune responses (SADII Research Projects 1-2); and (3) adverse reactions to vaccination (SADII Research Projects 1-2). We will provide quantitative analysis of clinical and immunological data to explore sex differences in vaccine-induced immune responses, including how sex intersects with other social stratifiers, such as age, race, and frailty, to influence immune responses and outcomes following influenza vaccination. We also will perform quantitative and qualitative data collection and analysis to explore gender differences in vaccine acceptance, immune responses, and adverse reactions, and how gender intersects with other social stratifiers, such as age, race, and frailty, to influence immune responses and outcomes following influenza vaccination. Finally, we will offer analysis of the interaction of sex and gender, including how sex and gender intersect with other social stratifiers, such as age, race, and frailty, to influence vaccine-induced immune responses and outcomes following influenza vaccination. Exploring how sex and gender intersect with other social stratifiers will enable us to explore differences between men and women, as well as differences among men and women in vaccine acceptance, immune responses, and adverse reactions to vaccination. In addition to supporting the SADII SCORE projects, the Sex and Gender Analysis Resource Core will also provide services to public health and clinical researchers interested in sex and gender analysis of qualitative and quantitative research, which is currently not available at Johns Hopkins.

不同性别人群对萨氏锥虫免疫力的差异 资源核心摘要 SADII性和性别分析核心将由迷迭香摩根博士和阿卜杜勒巴沙尼博士领导， 为人类研究项目提供分析支持（即，SADII研究项目1和2） SADII评分该核心将为可持续农业发展第二阶段所用的数据收集工具和方法提供投入 研究项目1和2，以更好地为相关的性和性别分析提供信息，并提供支持 对数据进行定性和定量分析，以检查和理解不同和重叠的 性和性别的贡献，以及它们与其他社会分层因素的交叉（例如，疫苗（疫苗）- 在年轻人和老年人中诱导免疫反应、不良反应和结果。具体来说，我们将 探索性别和性别差异：（1）流感疫苗接受（SADII研究项目2）;（2） 免疫反应（SADII研究项目1-2）;（3）疫苗接种的不良反应（SADII研究 项目1-2）。我们将提供临床和免疫学数据的定量分析来探索性别 疫苗诱导的免疫反应的差异，包括性别如何与其他社会分层因素交叉， 例如年龄、种族和虚弱，以影响流感疫苗接种后的免疫应答和结果。 我们还将进行定量和定性的数据收集和分析，以探讨性别差异， 疫苗接受，免疫反应和不良反应，以及性别如何与其他社会 年龄、种族和虚弱等分层因素影响流感后的免疫反应和结果 预防针最后，我们将分析性和性别的相互作用，包括性和性别是如何 与其他社会分层因素，如年龄、种族和脆弱性交叉，影响疫苗诱导免疫 流感疫苗接种后的反应和结果。探索性和性别如何与其他 社会分层将使我们能够探索男女之间的差异，以及 男性和女性在疫苗接受、免疫反应和疫苗接种不良反应方面的作用。此外 为了支持SADII SCORE项目，性别和性别分析资源核心还将提供 为对性和性别分析感兴趣的公共卫生和临床研究人员提供服务， 定量研究，这是目前在约翰霍普金斯大学没有的。