Harvard University Center for AIDS Research

项目摘要/摘要 总括 这项申请建议继续资助哈佛大学艾滋病研究中心(HU CFAR)。 HUCFAR是哈佛大学所有艾滋病研究的伞形组织，在教务长办公室运作。 它代表每个哈佛附属学校以及附属医院，包括Dana-Farber 癌症研究所，贝丝以色列女执事医疗中心，波士顿儿童医院，马萨诸塞州总医院 布里格姆妇女医院。此外，它还包括芬威健康，将其覆盖范围扩展到其他 哈佛大学以外的临床人群和转化性研究站点。胡CFAR建立协作和 提供基础设施支持，以协调和促进基础、临床、行为、 翻译和实施艾滋病毒研究。调查人员的研究重点包括研究 分子病毒学，发病机制，宿主免疫反应，流行病学，治疗，疫苗预防和 送货。CFAR还监督4个科学项目(卫生经济学和建模；艾滋病毒疫苗；艾滋病毒 根除)以及3个科学工作组(青少年与艾滋病毒、艾滋病毒与老龄化；生殖 艾滋病毒感染者的健康)。还确定了五个核心设施用于HU CFAR支持： 临床核心，生物统计学和生物信息学核心，人类免疫系统小鼠，核心高级 实验室技术核心、生物行为和社区科学核心。此外，行政部门 核心将提供战略规划和财政监督，发展和指导核心将支持 与科学方案和科学工作组的目标有关的创新试点项目，以及 为培养下一代艾滋病毒研究人员提供指导。承担以下具体工作 旨在，HU CFAR将继续发展，以满足其成员和NIH艾滋病研究的需求 优先事项，促进和促进CFAR在艾滋病研究方面的合作和跨学科活动 成员，作为哈佛大学机构间协作互动的典范。简而言之，我们建议： 1.促进和扩大多元化和高度一体化的多学科协同 成功的胡属艾滋病毒/艾滋病研究人员和他们的实习生 2.促进新的互动，支持能够更有效地开展创新研究的举措 处理与艾滋病毒/艾滋病有关的关键研究问题，旨在结束这一流行病 3.吸引、吸引、支持和指导下一代艾滋病毒/艾滋病早期职业研究人员 研究

PROJECT SUMMARY/ABSTRACT Overall This application proposes continued funding of the Harvard University Center for AIDS Research (HU CFAR). HU CFAR is the umbrella organization for all AIDS research at Harvard, operating out of the Provost's Office. It represents each of the Harvard affiliated schools as well as the affiliated hospitals, including Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Massachusetts General Hospital, Brigham & Women's Hospital. In addition, it includes Fenway Health, extending its reach to additional clinical populations and translational research sites outside Harvard. HU CFAR builds collaborations and provides infrastructure support to coordinate and promote emerging opportunities in basic, clinical, behavioral, translational and implementation HIV research. Research emphasis among investigators includes studies of molecular virology, pathogenesis, host immune responses, epidemiology, treatment, vaccines prevention and delivery. CFAR also oversees 4 Scientific Programs (Health Economics and Modeling; HIV Vaccines; HIV Eradication) as well as 3 Scientific Working Groups (Adolescents and HIV, HIV and Aging; Reproductive Health for HIV-Infected Populations). Five core facilities have also been identified for HU CFAR support: Clinical Core, Biostatistics and Bioinformatics Core, Human Immune System Mouse, Core Advanced Laboratory Technologies Core, Bio-Behavioral and Community Science Core. In addition, an Administrative Core will provide strategic planning and fiscal oversight, and a Developmental and Mentoring Core will support innovative pilot projects related to the goals of the scientific programs and scientific working groups, and provide mentorship to develop the next generation of HIV researchers. Undertaking the following specific aims, the HU CFAR will continue to evolve, to meet the needs of its members and the NIH AIDS research priorities by promoting and facilitating collaborative, cross-disciplinary activities in AIDS research among CFAR members, serving as a model for collaborative inter-institutional interactions at Harvard. Briefly, we propose to: 1. Facilitate and expand synergistic multidisciplinary collaborations among the diverse and highly successful HU-affiliated HIV/AIDS researchers and their trainees 2. Promote new interactions and support innovative research initiatives capable of more effectively addressing key HIV/AIDS related research questions aimed at bringing an end to the epidemic 3. Attract, engage, support and mentor the next generation of Early Career Investigators in HIV/AIDS research