Bio-Behavioral and Community Science Core

项目摘要/摘要 生物行为和社区科学核心(核心J) 我们建议继续生物行为和社区科学核心，以前称为行为和 社会科学核心，哈佛大学艾滋病研究中心(HU CFAR)。自2014年以来，这一核心 向CFAR成员提供咨询和其他支持，以设计利用 最先进的方法来开发干预措施，以限制艾滋病毒传播，并提高血清抗体水平 意识、护理参与度和服药依从性，同时解决社会和 阻碍实现这些目标的结构性因素。该核心的工作已经产生了4个HU CFAR 发展奖和25个NIH K-或R系列奖颁发给早期职业调查人员和多个 CFAR在本供资期间的合作。核心还领导了几项倡议，包括 与埃默里癌症研究中心共同领导设立了预防抗逆转录病毒药物工作组， 并积极参与跨CFAR行为和社会科学研究网络。这一核心具有 也越来越关注社区参与，核心领导层致力于参与 在研究过程中参与受影响的社区，并让所有主要利益攸关方参与 将生物行为、社会和社区研究整合到艾滋病毒的治疗、预防、治愈和治疗中 疫苗研发。最后，这一核心对协商的需求增加表明， 有兴趣整合这项研究。因此，我们提出了一个生物行为和社区科学核心 目标如下：1)为HU CFAR成员提供关于行为的协作和咨询服务， 艾滋病毒预防、治疗和转化研究的社会、结构和社区科学方面；2) 利用HU CFAR临床研究的基础设施，促进新的整合行为/社会和 社区科学研究；3)通过社区促进可持续的学术-社区伙伴关系 从事研究，包括初级调查人员的指导、教育和研究传播。 具体地说，核心将提供赠款提案方面的援助；就质量评估的方法进行协商 研究、干预开发、定量评估开发、混合方法研究，以及 基于社区的参与性研究。核心将继续通过促进HU CFAR增值 通过早期干预整合行为/社会科学的生物医学试验的成功 设计；通过促进行为/社会和生物医学研究相结合的想法；通过促进强大的 学术与社区的伙伴关系和获得社区的支持，以减少不信任并加快 将新技术推广到社区。

PROJECT SUMMARY/ABSTRACT Bio-Behavioral and Community Science Core (Core J) We propose to continue the Bio-behavioral and Community Science Core, formerly called the Behavioral and Social Sciences Core, for the Harvard University Center for AIDS Research (HU CFAR). Since 2014, this Core has provided consultations and other support to CFAR members for the design of research studies that utilize state-of-the-art methodologies to develop interventions to limit HIV transmission, and increase serostatus awareness, engagement in care, and medication adherence, while simultaneously addressing the social and structural factors that impede achieving these goals. The work of this Core has resulted in 4 HU CFAR Developmental awards and 25 NIH K- or R-series awards to Early Career Investigators and multiple inter- CFAR collaborations during the current funding period. The Core has also led several initiatives, including the establishment of the inter-CFAR Antiretrovirals for Prevention Working Group, co-led with the Emory CFAR, and active engagement in the trans-CFAR Behavioral and Social Science Research Network. This Core has also been increasingly focused on community engagement, and the Core leadership is dedicated to engaging affected communities in the research process and to engaging all key stakeholders about the need for integration of bio-behavioral, social, and community-based research in HIV treatment, prevention, cure, and vaccine development. Finally, the increased demand for consultations by this Core indicates a greater interested in integrating this research. Thus, we propose a Bio-behavioral and Community Science Core with the following goals: 1) To provide collaborative and consultation services to HU CFAR members on behavioral, social, structural, and community science aspects of HIV prevention, treatment, and translational research; 2) To leverage infrastructure from HU CFAR clinical research to facilitate new integrative behavioral/social and community science studies; 3) To foster sustainable academic-community partnerships through community engaged research including mentorship of junior investigators, education, and research dissemination. Specifically, the Core will offer assistance with grant proposals; consultations on methods for qualitative research, intervention development, quantitative assessment development, mixed-method research, and community-based participatory research. The Core will continue to add value to the HU CFAR by facilitating the success of biomedical trials through the integration of behavioral/social sciences early in intervention design; by catalyzing ideas for combined behavioral/social and biomedical research; and by facilitating strong academic-community partnerships and obtaining community buy-in, to reduce mistrust and to the hasten the reach of new technologies into communities.