Making it last: A randomized, controlled trial of a home care system to promote persistence in PrEP care
让它持久:一项随机对照家庭护理系统试验,以促进 PrEP 护理的持久性
基本信息
- 批准号:9410856
- 负责人:
- 金额:$ 112.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-25 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAddressAdherenceAdultBehavior assessmentBehavioralBiological MarkersBostonCDC7 geneCaringCenters for Disease Control and Prevention (U.S.)ClinicCohort StudiesContinuity of Patient CareCost AnalysisCost SavingsCounselingCreatinineDiphosphatesDoseDropsEffectivenessEffectiveness of InterventionsEligibility DeterminationHIVHIV InfectionsHIV/STDHealthcareHealthcare SystemsHome environmentHome visitationHospitalsHourInterventionInterviewLabelLaboratoriesMeasurableMeasuresMediator of activation proteinMedicalMethodsMinorityMonitorParticipantPatient Self-ReportPatientsPersonsPharmaceutical PreparationsPopulationProviderPublic HealthRandomizedRandomized Controlled TrialsRecruitment ActivityResearchResidual stateRiskRisk ReductionSamplingSelf EfficacySelf MedicationServicesSiteSubgroupSupport SystemSurveysSystemTechnologyTenofovirTestingTheoretical modelTimeUnited StatesVisitagedarmbaseblack men who have sex with mencare systemscohortcost effectivenesscost utility analysisdemographicsdisorder preventioneffectiveness trialefficacy trialfollow-uphigh riskhigh risk menmathematical modelmen who have sex with menopportunity costpatient home carepillpre-exposure prophylaxisprimary outcomesample collectionscale upsecondary analysissecondary outcomeseroconversionstandard of caretransmission processtrial comparing
项目摘要
PROJECT SUMMARY/ABSTRACT
HIV pre-exposure prophylaxis (PrEP) has been shown in efficacy and effectiveness trials to achieve high levels
of protection, with over 95% protection among those with measurable levels of medication that indicate
adherence. This provides a substantial public health opportunity, with the US Centers for Disease Control and
Prevention (CDC) estimating that approximately 1.2 million US adults are eligible for PrEP, including 492,000
MSM. PrEP prescriptions are growing exponentially, with over 79,000 prescriptions between 2012 and 2015 in
the US. Guidance issued by CDC and by WHO calls for quarterly follow-up visits for those on PrEP, to include
behavioral and laboratory assessments, and treatment or counseling as needed. Currently, those on PrEP
must have in-person visits with their medical provider for such services, a system that places a large burden on
both providers and patients. If PrEP were to be scaled up to cover eligible, high-risk MSM in the United States,
we estimate over 1.5 million yearly patient visits would be required, a substantial burden on clinics seeking to
bring PrEP to scale. A related problem with bringing PrEP to scale is that patients may not persist in PrEP care
over time. This is particularly concerning because those patients in demographics with highest risk for HIV
acquisition, young and Black MSM, have been observed to be more likely to not persist in PrEP care over time.
The proposed research seeks to make PrEP scale-up more feasible and to increase persistence in PrEP care,
by developing a home-based monitoring and support system that would alleviate the need for quarterly, in-
person provider visits. We propose to conduct a randomized, controlled trial to determine whether participants
(half Black, half aged 18-34) randomized to the home care PrEP system have higher levels of retention in
PrEP care relative to standard of care control participants, as determined by biomarker and self-report. The
trial will be conducted at sites in Atlanta, GA, Boston, MA, Jackson, MS, and St. Louis, MO. We will also
conduct a mixed-methods assessment of trial results, and assess the cost-effectiveness of the home care
system.
项目总结/摘要
艾滋病毒暴露前预防(PrEP)已在疗效和有效性试验中显示,
保护,其中超过95%的保护与可测量的药物水平,表明
坚持。这提供了一个巨大的公共卫生机会,美国疾病控制中心和
美国疾病预防控制中心(CDC)估计,大约有120万美国成年人有资格接受PrEP,其中包括492,000人
男男性接触者PrEP处方呈指数级增长,2012年至2015年期间,
美方疾病预防控制中心和世卫组织发布的指南要求对PrEP患者进行季度随访,包括
行为和实验室评估,以及根据需要进行治疗或咨询。目前,那些在PrEP
必须亲自与他们的医疗提供者进行这种服务,这一系统给他们带来了很大的负担。
提供者和患者。如果要扩大PrEP的规模,以覆盖美国符合条件的高风险MSM,
我们估计每年需要超过150万人次的病人就诊,这对寻求
将PrEP推向规模。将PrEP规模化的一个相关问题是,患者可能无法坚持PrEP护理
随着时间这一点尤其令人担忧,因为那些艾滋病毒感染风险最高的患者
已经观察到,随着时间的推移,年轻和黑人MSM更有可能不坚持PrEP护理。
拟议的研究旨在使PrEP规模扩大更加可行,并增加PrEP护理的持久性,
开发一个以家庭为基础的监测和支持系统,以减轻对季度,
提供者访问。我们建议进行随机对照试验,以确定参与者是否
(half黑人,一半年龄在18-34岁之间)随机分配到家庭护理PrEP系统,
根据生物标志物和自我报告确定的相对于标准护理对照参与者的PrEP护理。的
试验将在佐治亚州亚特兰大、马萨诸塞州波士顿、密西西比州杰克逊和密苏里州圣路易斯的研究中心进行。我们还将
对试验结果进行混合方法评估,并评估家庭护理的成本效益
系统
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
KENNETH H MAYER其他文献
KENNETH H MAYER的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('KENNETH H MAYER', 18)}}的其他基金
Fenway Community Health Center, Inc., Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)
芬威社区健康中心有限公司站点联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心(UM2 临床试验可选)
- 批准号:
10599561 - 财政年份:2022
- 资助金额:
$ 112.67万 - 项目类别:
Fenway Community Health Center, Inc., Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)
芬威社区健康中心有限公司站点联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心(UM2 临床试验可选)
- 批准号:
10709608 - 财政年份:2022
- 资助金额:
$ 112.67万 - 项目类别:
Evaluation of Life-Steps to Enhance Adherence and Engagement in PrEP Care
评估提高 PrEP 护理依从性和参与度的生活步骤
- 批准号:
10009463 - 财政年份:2019
- 资助金额:
$ 112.67万 - 项目类别:
Evaluation of Life-Steps to Enhance Adherence and Engagement in PrEP Care
评估提高 PrEP 护理依从性和参与度的生活步骤
- 批准号:
10241375 - 财政年份:2019
- 资助金额:
$ 112.67万 - 项目类别:
Evaluation of Life-Steps to Enhance Adherence and Engagement in PrEP Care
评估提高 PrEP 护理依从性和参与度的生活步骤
- 批准号:
10478282 - 财政年份:2019
- 资助金额:
$ 112.67万 - 项目类别:
Evaluation of Life-Steps to Enhance Adherence and Engagement in PrEP Care
评估提高 PrEP 护理依从性和参与度的生活步骤
- 批准号:
10683418 - 财政年份:2019
- 资助金额:
$ 112.67万 - 项目类别:
Making it last: A randomized, controlled trial of a home care system to promote persistence in PrEP care
让它持久:一项随机对照家庭护理系统试验,以促进 PrEP 护理的持久性
- 批准号:
10191050 - 财政年份:2017
- 资助金额:
$ 112.67万 - 项目类别:
Feasibility of Short-Term PrEP Uptake for MSM with Episodic High-Risk for HIV
具有偶发性 HIV 高风险的 MSM 短期接受 PrEP 的可行性
- 批准号:
8845287 - 财政年份:2015
- 资助金额:
$ 112.67万 - 项目类别:
Optimizing Antiretroviral-Based Prevention by Enhancing PrEP Adherence in MSM
通过增强 MSM 的 PrEP 依从性来优化基于抗逆转录病毒的预防
- 批准号:
8209569 - 财政年份:2011
- 资助金额:
$ 112.67万 - 项目类别:
相似海外基金
Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
- 批准号:
10594350 - 财政年份:2023
- 资助金额:
$ 112.67万 - 项目类别:
Evaluating Centralizing Interventions to Address Low Adherence to Lung Cancer Screening Follow-up in Decentralized Settings
评估集中干预措施,以解决分散环境中肺癌筛查随访依从性低的问题
- 批准号:
10738120 - 财政年份:2023
- 资助金额:
$ 112.67万 - 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
- 批准号:
10526768 - 财政年份:2022
- 资助金额:
$ 112.67万 - 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
- 批准号:
10701072 - 财政年份:2022
- 资助金额:
$ 112.67万 - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10679092 - 财政年份:2021
- 资助金额:
$ 112.67万 - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10432133 - 财政年份:2021
- 资助金额:
$ 112.67万 - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10327065 - 财政年份:2021
- 资助金额:
$ 112.67万 - 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
- 批准号:
10377366 - 财政年份:2019
- 资助金额:
$ 112.67万 - 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
- 批准号:
10574496 - 财政年份:2019
- 资助金额:
$ 112.67万 - 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
- 批准号:
9403567 - 财政年份:2017
- 资助金额:
$ 112.67万 - 项目类别: