7th GenTAC Thoracic Aortic Disease Summit

本申请是为第七届GenTAC胸主动脉疾病峰会征集支持。 2022年4月28日，法国巴黎。这次独特的会议汇聚了临床医生的多学科小组， 科学家和工程师推动我们对胸主动脉疾病的潜在机制的理解 并提高我们治疗这些疾病患者的能力，其中包括年轻人和 年长的。第七届GenTAC峰会将首次在协作性第11届国际研究研讨会上举行 关于马凡综合症(4月24日至27日在同一地点举行)，是与马凡基金会联合举办的。 这种共享会议不仅提供了一个分享和审查想法的论坛，还提供了一个新的合作 都是天生的。一年两次的GenTAC会议始于2009年，作为国家登记处使命的一部分 遗传触发的胸主动脉瘤及相关心血管疾病(GenTAC)。GenTAC 由NHLBI和NIAMS资助，从2006年到2016年登记和跟踪了3600多名患者。Gentac 联盟成立于2017年，旨在利用GenTAC创造的协同与协作。第五代TAC 峰会于2018年10月6日至7日在俄勒冈州波特兰的OHSU举行，第六届GenTAC峰会几乎定于 应对2020年10月10日/11日的新冠肺炎大流行。 这次为期1天的GenTAC峰会的初步计划包括：(1)家族性主动脉病变， (Ii)二尖瓣主动脉瓣；(Iii)Turner综合征；(Iv)急性主动脉综合征。将有协同效应与 第十一届马凡氏综合征研究研讨会议程。我们预计临床医生和研究人员将 参加代表包括马凡在内的胸主动脉瘤领域不同群体的两次会议 基金会、IRAD、Montalcino主动脉联盟、BAVCON、EDS-PCORI、Turners和欧洲血管 网络都在参与其中。我们已经确认了80%的受邀演讲者。学员的参与和 未被充分代表的少数群体特别受到鼓舞，颁发了10个旅行奖项。 这次会议由马凡基金会和加州大学弗兰克尔心血管中心主办。 密歇根州。核心会议组织委员会包括Marion A Hofmann Bowman博士和Kim博士 Eagle作为这笔赠款的主要研究人员，以及来自Marfan基金会的Josephine Grima博士。这 团队还成功组织了2020第六届GenTAC会议。金·A·伊格尔是《弗兰克尔》的导演 密歇根大学心血管中心、NHLBI赞助的GenTAC联盟主席 2006-2016年间，他担任GenTAC注册中心的研究主席。马里恩·霍夫曼·鲍曼博士是一位 哥伦比亚大学MiAorta项目临床副教授兼执行医学主任 密歇根州。她的专长是与胸主动脉疾病相关的临床翻译研究。

This application is in request for support for the 7th GenTAC Thoracic Aortic Disease Summit to be held in Paris, France on April 28, 2022. This unique meeting brings together multidisciplinary groups of clinicians, scientists, and engineers to advance our understanding of the underlying mechanisms of thoracic aortic disease and to improve our ability to treat those who are afflicted by these conditions, which includes both young and old. The 7th GenTAC summit for the first time will be held in collaboration 11th International Research Symposium on Marfan Syndrome (held April 24-27 at the same location) and is organized jointly with the Marfan Foundation. This shared meetings provides a forum not only where ideas are shared and scrutinized, but new collaborations are born. The biannual GenTAC conference originated in 2009 as part of the mission of the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Related Cardiovascular Conditions (GenTAC). GenTAC was funded by NHLBI and NIAMS and enrolled and followed over 3600 patients from 2006 through 2016. Gentac Alliance was initiated in 2017 to harness the synergy and collaboration created by the GenTAC. The 5th GenTAC Summit was held on Oct 6-7, 2018 at OHSU in Portland, OR and the 6th GenTAC Summit was held virtually due to the covid-19 pandemic on October 10/11 2020. The preliminary program for this 1-day GenTAC summit includes scientific sessions on (i) Familial Aortopathy, (ii) Bicuspid aortic valve, (iii) Turner Syndrome, and (iv) Acute aortic syndrome. There will be synergy with the program of the 11th Research Symposium on Marfan syndrome. We anticipate that clinicians and researcher will attend both meetings representing different groups in the field of thoracic aortic aneurysms including Marfan Foundation, IRAD, Montalcino Aortic Consortium, BAVCON, EDS-PCORI, Turners, and European Vascular Network are participating. We have >80% of invited speakers are confirmed. Participation of trainees and underrepresented minorities is especially encouraged by awarding 10 travel awards. The meeting is hosted by Marfan Foundation and the Frankel Cardiovascular Center at the University of Michigan. The core conference organization committee includes Dr. Marion A Hofmann Bowman and Dr. Kim Eagle as the principal investigators of this grant, and Dr. Josephine Grima from the Marfan Foundation. This team also successfully organized the 2020 6th GenTAC meeting. Kim A. Eagle is the Director of the Frankel Cardiovascular Center at the University of Michigan and the chair of the NHLBI sponsored GenTAC Alliance and he served as the study chair of the GenTAC registry from 2006-2016. Dr. Marion A Hofmann Bowman is a Clinical Associate Professor and Executive Medical Director of the MiAorta program at the University of Michigan. Her expertise is in clinical-translational research related to thoracic aortic disease.