2022 Fibroblast Growth Factors in Development and Disease GRC and GRS

2022 发育和疾病中的成纤维细胞生长因子 GRC 和 GRS

• 批准号: 10462966
• 负责人: Amy E Merrill
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462966
• 关键词: Address; Adult; Affect; Aging; Area; Attention; Autophagocytosis; Biological Process; Biology; COVID-19 pandemic; Cancer Biology; Cell Communication; Cells; Collaborations; Complex; Congenital Abnormality; Congenital Disorders; Data; Development; Diabetes Mellitus; Discipline; Disease; Embryonic Development; Endocrine; Ensure; Ethnic Origin; Event; Faculty; Feedback; Female; Fibroblast Growth Factor; Fibroblast Growth Factor Receptors; Future Generations; Gender; Generations; Geographic Locations; Geography; Germ Layers; Goals; Growth Factor Interaction; Health; Homeostasis; Hour; Human; Industry; Inflammatory; International; Italy; Knowledge; Ligands; Malignant Neoplasms; Mentors; Metabolic; Metabolic Diseases; Metabolic Pathway; Metabolism; Multiple Sclerosis; Musculoskeletal System; Mutation; Natural regeneration; Nervous system structure; Organogenesis; Participant; Pathway interactions; Pharmacology; Physiological; Postdoctoral Fellow; Research; Research Personnel; Role; Science; Scientist; Signal Pathway; Signal Transduction; Skeleton; Syndrome; System; Technology; Therapeutic; Tissues; Translations; Travel; Underrepresented Minority; Visual; Woman; autocrine; base; craniofacial complex; graduate student; human disease; inhibitor; innovation; innovative technologies; inorganic phosphate; interest; meetings; member; multidisciplinary; nervous system disorder; novel; novel strategies; optogenetics; paracrine; phosphoproteomics; posters; programs; protein complex; receptor; repaired; senescence; sensory system; stem cells; structural biology; success; symposium; therapeutic target; tissue repair; tool

PROJECT SUMMARY Fibroblast Growth Factors (FGFs) and their receptors (FGFRs) regulate almost all aspects of normal embryonic development, and key homeostatic, metabolic and repair mechanism in select adult tissues. Accordingly, defective FGF signaling results in a wide range of diseases including congenital birth defects, neurological disorders, metabolic diseases, inflammatory syndromes, and cancer. The field of FGF signaling, therefore, unites diverse biomedical disciplines that significantly impact human health. The overall goal of this proposal is to galvanize multidisciplinary interactions between academic scientists, clinicians, and industry leaders with a common interest in FGF biology for the benefit of human health. This goal will be achieved by gathering the top FGF-biology researchers in Il Ciocco, Italy between April 30th to May 6th, 2022, at the 8th Gordon Research Conference (GRC) on FGFs in Development and Disease 2022 conference entitled “FGF Signaling: Understanding Function and Devising Therapeutic Tools”. Prior to this GRC, an associated two-day Gordon Research Seminar (GRS), entitled “Biology, Technology and Translation in FGF Research”, organized by graduate students and postdoctoral fellows will ensure the mentoring of a new generation of FGF researchers. More specifically, the goal of this proposal will be realized through the following Specific Aims: (1) showcase new innovations that impact our mechanistic understanding of FGF-related diseases and their therapeutic advancement by featuring presentations from established leaders and new innovators; (2) encourage scientific discussions and new collaborations among trainees, scientists, and clinicians through extended poster sessions and networking opportunities; and (3) grow our existing network and capacity for future generations of FGF researchers by providing travel support and scientific feedback for trainees and junior faculty members. This GRC, postponed from its 2020 date due to the Covid19 pandemic, provides an international forum for researchers and trainees to share unique perspectives on the diverse biological functions of FGF signaling and forges new collaborations amongst these scientists. New and emerging topics such as autophagy, diabetes, multiple sclerosis and FGF's interaction with other signaling pathways will be covered. To maximize the success of the 2022 meeting, the program places particular importance on balanced speaker and attendee representation from diverse geographical locations, gender and ethnicity. Moreover, a `Power Hour' is dedicated to discussing current obstacles to, and novel approaches for, promoting wider participation of women in science.

项目摘要 成纤维细胞生长因子（FGFS）及其受体（FGFR）几乎调节正常胚胎的所有方面 精选成人组织中的开发以及关键的稳态，代谢和修复机制。因此， FGF信号有缺陷导致多种疾病，包括先天性先天缺陷，神经系统 疾病，代谢疾病，炎症综合征和癌症。因此，FGF信号传导的字段是单位 潜水员的生物医学学科，显着影响人类健康。该提议的总体目标是 通过学术科学家，临床医生和行业领导者之间的多学科互动来激发与 FGF生物学对人类健康的利益的共同兴趣。这个目标将通过聚集顶部来实现 4月30日至2022年5月6日，在第八届戈登研究 FGF在开发和疾病中的FGF会议（GRC）2022会议，题为“ FGF信号： 了解功能并设计治疗工具”。 研究研讨会（GRS），题为“ FGF研究中的生物学，技术和翻译”，由 研究生和博士后研究员将确保新一代FGF研究人员的心理。 更具体地说，该提案的目标将通过以下特定目的实现：（1）展示新的 影响我们对FGF相关疾病的机械理解及其治疗的创新 通过展示既定领导者和新创新者的演讲，进步； （2）鼓励科学 通过扩展海报会议，学员，科学家和临床医生之间的讨论和新合作 和网络机会； （3）提高我们的现有网络和未来的FGF的能力 研究人员通过为学员和初级教师提供旅行支持和科学反馈。这 GRC从2020年开始由于COVID19大流行而推迟，为国际论坛提供了一个国际论坛 研究人员和学员分享有关FGF信号的潜水生物学功能的独特观点和 在这些科学家中建立了新的合作。新的和新兴的主题，例如自噬，糖尿病， 将涵盖多发性硬化症和FGF与其他信号通路的相互作用。最大化成功 在2022年会议中，该计划特别重要 来自潜水员地理位置，性别和种族。此外，“电力时光”专门讨论 当前的障碍和新颖的方法是促进妇女参与科学的广泛参与。