2022 Fibroblast Growth Factors in Development and Disease GRC and GRS

2022 发育和疾病中的成纤维细胞生长因子 GRC 和 GRS

• 批准号: 10462966
• 负责人: Amy E Merrill
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462966
• 关键词: Address; Adult; Affect; Aging; Area; Attention; Autophagocytosis; Biological Process; Biology; COVID-19 pandemic; Cancer Biology; Cell Communication; Cells; Collaborations; Complex; Congenital Abnormality; Congenital Disorders; Data; Development; Diabetes Mellitus; Discipline; Disease; Embryonic Development; Endocrine; Ensure; Ethnic Origin; Event; Faculty; Feedback; Female; Fibroblast Growth Factor; Fibroblast Growth Factor Receptors; Future Generations; Gender; Generations; Geographic Locations; Geography; Germ Layers; Goals; Growth Factor Interaction; Health; Homeostasis; Hour; Human; Industry; Inflammatory; International; Italy; Knowledge; Ligands; Malignant Neoplasms; Mentors; Metabolic; Metabolic Diseases; Metabolic Pathway; Metabolism; Multiple Sclerosis; Musculoskeletal System; Mutation; Natural regeneration; Nervous system structure; Organogenesis; Participant; Pathway interactions; Pharmacology; Physiological; Postdoctoral Fellow; Research; Research Personnel; Role; Science; Scientist; Signal Pathway; Signal Transduction; Skeleton; Syndrome; System; Technology; Therapeutic; Tissues; Translations; Travel; Underrepresented Minority; Visual; Woman; autocrine; base; craniofacial complex; graduate student; human disease; inhibitor; innovation; innovative technologies; inorganic phosphate; interest; meetings; member; multidisciplinary; nervous system disorder; novel; novel strategies; optogenetics; paracrine; phosphoproteomics; posters; programs; protein complex; receptor; repaired; senescence; sensory system; stem cells; structural biology; success; symposium; therapeutic target; tissue repair; tool

PROJECT SUMMARY Fibroblast Growth Factors (FGFs) and their receptors (FGFRs) regulate almost all aspects of normal embryonic development, and key homeostatic, metabolic and repair mechanism in select adult tissues. Accordingly, defective FGF signaling results in a wide range of diseases including congenital birth defects, neurological disorders, metabolic diseases, inflammatory syndromes, and cancer. The field of FGF signaling, therefore, unites diverse biomedical disciplines that significantly impact human health. The overall goal of this proposal is to galvanize multidisciplinary interactions between academic scientists, clinicians, and industry leaders with a common interest in FGF biology for the benefit of human health. This goal will be achieved by gathering the top FGF-biology researchers in Il Ciocco, Italy between April 30th to May 6th, 2022, at the 8th Gordon Research Conference (GRC) on FGFs in Development and Disease 2022 conference entitled “FGF Signaling: Understanding Function and Devising Therapeutic Tools”. Prior to this GRC, an associated two-day Gordon Research Seminar (GRS), entitled “Biology, Technology and Translation in FGF Research”, organized by graduate students and postdoctoral fellows will ensure the mentoring of a new generation of FGF researchers. More specifically, the goal of this proposal will be realized through the following Specific Aims: (1) showcase new innovations that impact our mechanistic understanding of FGF-related diseases and their therapeutic advancement by featuring presentations from established leaders and new innovators; (2) encourage scientific discussions and new collaborations among trainees, scientists, and clinicians through extended poster sessions and networking opportunities; and (3) grow our existing network and capacity for future generations of FGF researchers by providing travel support and scientific feedback for trainees and junior faculty members. This GRC, postponed from its 2020 date due to the Covid19 pandemic, provides an international forum for researchers and trainees to share unique perspectives on the diverse biological functions of FGF signaling and forges new collaborations amongst these scientists. New and emerging topics such as autophagy, diabetes, multiple sclerosis and FGF's interaction with other signaling pathways will be covered. To maximize the success of the 2022 meeting, the program places particular importance on balanced speaker and attendee representation from diverse geographical locations, gender and ethnicity. Moreover, a `Power Hour' is dedicated to discussing current obstacles to, and novel approaches for, promoting wider participation of women in science.

项目摘要 成纤维细胞生长因子（FGF）及其受体（FGFR）调节正常胚胎发育的几乎所有方面。 发育和关键的稳态，代谢和修复机制在选择成人组织。因此，委员会认为， 缺陷的FGF信号传导导致广泛的疾病，包括先天性出生缺陷、神经系统疾病、神经系统 疾病、代谢疾病、炎性综合征和癌症。因此，FGF信号传导领域 对人类健康产生重大影响的各种生物医学学科。本提案的总体目标是 激发学术科学家，临床医生和行业领导者之间的多学科互动， 共同关注FGF生物学，造福人类健康。这一目标将通过聚集高层 2022年4月30日至5月6日，意大利Il Ciocco的FGF生物学研究人员在第八届戈登研究中心举行。 2022年关于FGF在发育和疾病中的作用的会议（GRC），题为“FGF信号传导： 了解功能和设计治疗工具”。在此之前，一个为期两天的戈登 研究研讨会（GRS），题为“生物学，技术和翻译在FGF研究”，由 研究生和博士后研究员将确保指导新一代的FGF研究人员。 更具体地说，本提案的目标将通过以下具体目标实现：（1）展示新的 这些创新影响了我们对FGF相关疾病及其治疗的机械理解， （2）鼓励科学研究， 通过扩展的海报会议，学员、科学家和临床医生之间进行讨论和新的合作 和网络的机会;以及（3）为未来几代的FGF发展我们现有的网络和能力 研究人员通过为学员和初级教员提供旅行支持和科学反馈。这 由于Covid 19大流行，GRC从2020年推迟到2020年，为以下方面提供了一个国际论坛 研究人员和学员分享FGF信号传导的不同生物学功能的独特观点， 在这些科学家之间建立了新的合作。新的和新兴的主题，如自噬，糖尿病， 多发性硬化症和FGF与其他信号通路的相互作用将被覆盖。为了最大限度地成功 在2022年的会议中，该计划特别重视平衡发言者和与会者的代表性 来自不同的地理位置、性别和种族。此外，一个“电源小时”专门讨论 促进妇女更广泛参与科学的现有障碍和新办法。