2022 Mutagenesis Gordon Research Conference and Gordon Research Seminar

项目总结/摘要 2022年戈登突变研究会议将探讨前沿研究， 生物体基因组序列变化的机制和后果， 生命的分支。生物体遗传蓝图的改变是许多生物体 生物学和病理学方面。尽管"诱变"是一个既定的会议， 仍然是一个前沿话题，跨越了许多领域的传统界限。它推动了进化 癌症，细菌逃脱抗生素的杀伤以及有益的过程， 病毒限制和有效的适应性免疫。重要的是，常见的分子机制 将这些显然不同的进程联系起来，会议的一个主要目标是汇集 通常不强烈相互作用的场。此外，会议将突出一系列广泛的 从深度测序到单分子生物物理学的实验方法， 所有职业阶段和背景的科学家，从学术界到工业界。GRC将 包括28位特邀讲者，24个演讲时段，从摘要中选出， 一个互动海报会议。此外，在主要会议之前举行的GRS将有 专门为研究生和博士后提供进一步的口头和海报展示机会， 以及职业小组讨论。主要会议中的"动力小时"将侧重于 妇女在科学领域面临的挑战。我们的目标是营造一个互动、友好的环境， 思想可以自由交流，不分背景或资历。为此， 会议和工作餐将补充一个积极的社会计划，以促进 这些互动。GRC计划将分为九个上午和晚上 专题会议：（1）诱变的基本机制（主旨会议）;（2）DNA 复制叉的损伤耐受性;（3）可视化诱变机制;（4）诱变 由复制错误引起;（5）RNA依赖性诱变;（6）重复和屏障诱导 诱变;（7）了解癌症和衰老中的诱变特征;（8）环境 （9）进化与适应。因此，GRC和GRS将 促进诱变和驱动广泛领域的最新思想和技术的交流 新的想法和跨领域的合作，同时加强和促进下一个职业生涯 在这个充满活力和令人兴奋的领域的一代科学家。

Project Summary / Abstract The 2022 Gordon Research Conference on Mutagenesis will explore cutting edge research into the mechanisms and consequences of changes in the genomic sequence of organisms from all branches of life. Alterations to the genetic blueprint of an organisms lies at the heart of many aspects of biology and pathology. Despite being a well-established conference, `Mutagenesis' remains a forefront topic, bridging the traditional boundaries of many fields. It drives the evolution of cancer, the escape of bacteria from killing by antibiotics as well as beneficial processes such as viral restriction and effective adaptive immunity. Importantly, common molecular mechanisms link these apparently diverse processes and a key aim of the conference will be to bring together fields that do not normally interact strongly. Further, the meeting will highlight a wide range of experimental approaches from deep sequencing to single molecule biophysics and bring together scientists of all career stages and backgrounds, from academia to industry. The GRC will comprise 28 invited speakers with 24 slots for talks to be selected from the abstracts as well as an interactive poster session. In addition, the GRS, which precedes the main conference will have further oral and poster presentation opportunities specifically for graduate students and post-docs, as well as a career panel discussion. A `power hour' in the main meeting will focus on the challenges facing women in science. We aim to foster an interactive, friendly environment in which ideas can be freely exchanged independently of background or seniority. To that end, the sessions and working meals will be supplemented with a vigorous social program to foster these interactions. The GRC program will be organized into nine morning and evening sessions entitled: (1) Fundamental mechanisms of mutagenesis (Keynote session); (2) DNA damage tolerance at the replication fork; (3) Visualizing mutagenic mechanisms; (4) Mutagenesis arising from replication errors; (5) RNA-dependent mutagenesis; (6) Repeat and barrier-induced mutagenesis; (7) Understanding mutagenic signatures in cancer and aging; (8) Environmental and endogenous mutagenesis and (9) Evolvability and adaptation. The GRC and GRS will thus promote exchange of the latest ideas and techniques in the broad field of mutagenesis and drive new ideas and cross-field collaborations while enhancing and promoting the careers of the next generation of scientists in this dynamic and exciting field.