2022 Mutagenesis Gordon Research Conference and Gordon Research Seminar

2022年诱变戈登研究会议暨戈登研究研讨会

• 批准号: 10462054
• 负责人: Houra Merrikh
• 金额: $ 1.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-21 至 2023-03-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462054
• 关键词: Academia; Aging; Antibiotic Resistance; Antibiotics; Antibodies; Architecture; Area; Automobile Driving; Bacteria; Behavior; Bioinformatics; Biological Models; Biology; Biophysics; California; Carcinogenesis Mechanism; Cells; Collaborations; DNA Damage; DNA Repair; DNA Sequence; DNA replication fork; Development; Discipline; Ensure; Environment; Evolution; Feeling; Fellowship; Fertilization; Fostering; Funding Opportunities; Genetic; Genomic Instability; Genomics; Health; Heart; Hour; Human; Immune response; Immunoglobulin Genes; Industry; Invaded; Invertebrates; Life; Link; Location; Maine; Malignant Neoplasms; Mammalian Chromosomes; Mammals; Medicine; Modernization; Molecular; Mutagenesis; Mutation; Oral; Organism; Pathology; Play; Postdoctoral Fellow; Process; RNA; Replication Error; Research; Research Personnel; Resistance; Rural; Science; Scientist; Series; Site; Techniques; Therapeutic Intervention; Time; Underrepresented Minority; Viral; Woman; Work; Yeasts; adaptive immunity; cancer cell; career; chemotherapy; chromosome replication; commune; deep sequencing; environmental mutagens; fight against; graduate student; meetings; microorganism; next generation; pathogen; posters; programs; recruit; repaired; single molecule; social; symposium; trait

Project Summary / Abstract The 2022 Gordon Research Conference on Mutagenesis will explore cutting edge research into the mechanisms and consequences of changes in the genomic sequence of organisms from all branches of life. Alterations to the genetic blueprint of an organisms lies at the heart of many aspects of biology and pathology. Despite being a well-established conference, `Mutagenesis' remains a forefront topic, bridging the traditional boundaries of many fields. It drives the evolution of cancer, the escape of bacteria from killing by antibiotics as well as beneficial processes such as viral restriction and effective adaptive immunity. Importantly, common molecular mechanisms link these apparently diverse processes and a key aim of the conference will be to bring together fields that do not normally interact strongly. Further, the meeting will highlight a wide range of experimental approaches from deep sequencing to single molecule biophysics and bring together scientists of all career stages and backgrounds, from academia to industry. The GRC will comprise 28 invited speakers with 24 slots for talks to be selected from the abstracts as well as an interactive poster session. In addition, the GRS, which precedes the main conference will have further oral and poster presentation opportunities specifically for graduate students and post-docs, as well as a career panel discussion. A `power hour' in the main meeting will focus on the challenges facing women in science. We aim to foster an interactive, friendly environment in which ideas can be freely exchanged independently of background or seniority. To that end, the sessions and working meals will be supplemented with a vigorous social program to foster these interactions. The GRC program will be organized into nine morning and evening sessions entitled: (1) Fundamental mechanisms of mutagenesis (Keynote session); (2) DNA damage tolerance at the replication fork; (3) Visualizing mutagenic mechanisms; (4) Mutagenesis arising from replication errors; (5) RNA-dependent mutagenesis; (6) Repeat and barrier-induced mutagenesis; (7) Understanding mutagenic signatures in cancer and aging; (8) Environmental and endogenous mutagenesis and (9) Evolvability and adaptation. The GRC and GRS will thus promote exchange of the latest ideas and techniques in the broad field of mutagenesis and drive new ideas and cross-field collaborations while enhancing and promoting the careers of the next generation of scientists in this dynamic and exciting field.

项目概要/摘要 2022 年戈登诱变研究会议将探讨以下领域的前沿研究 所有生物体基因组序列变化的机制和后果 生命的分支。生物体遗传蓝图的改变是许多问题的核心 生物学和病理学方面。尽管“诱变”是一个成熟的会议 仍然是一个前沿话题，弥合了许多领域的传统界限。它推动着进化 癌症的发生、细菌免于被抗生素杀死以及诸如此类的有益过程 如病毒限制和有效的适应性免疫。重要的是，常见的分子机制 将这些明显不同的进程联系起来，会议的一个主要目标是将 通常相互作用不强烈的场。此外，本次会议还将重点讨论一系列议题 从深度测序到单分子生物物理学的实验方法，并将 从学术界到工业界，各个职业阶段和背景的科学家。 GRC将 包括 28 位受邀演讲者，其中有 24 个演讲席位，从摘要中选出 互动海报会议。此外，在主会议之前举行的 GRS 将有 专门为研究生和博士后提供的更多口头和海报展示机会， 以及职业小组讨论。主会议的“权力时刻”将重点关注 女性在科学领域面临的挑战。我们的目标是营造一个互动、友好的环境 思想可以自由交流，不受背景或资历的影响。为此， 会议和工作餐将辅之以积极的社会计划，以促进 这些相互作用。 GRC节目将分为上午和晚上九场 会议主题为：(1) 诱变的基本机制（主题会议）； (2)DNA 复制叉处的损伤容限； (3) 诱变机制可视化； (4)诱变 由复制错误引起的； (5)RNA依赖性诱变； (6) 重复和障碍诱导 诱变； (7) 了解癌症和衰老中的突变特征； (8) 环境 和内源诱变；（9）进化性和适应。因此，GRC 和 GRS 将 促进诱变和驱动广泛领域的最新思想和技术的交流 新想法和跨领域合作，同时增强和促进下一代的职业生涯 在这个充满活力和令人兴奋的领域培养了一代科学家。