2022 Mutagenesis Gordon Research Conference and Gordon Research Seminar

2022年诱变戈登研究会议暨戈登研究研讨会

• 批准号: 10462054
• 负责人: Houra Merrikh
• 金额: $ 1.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-21 至 2023-03-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462054
• 关键词: Academia; Aging; Antibiotic Resistance; Antibiotics; Antibodies; Architecture; Area; Automobile Driving; Bacteria; Behavior; Bioinformatics; Biological Models; Biology; Biophysics; California; Carcinogenesis Mechanism; Cells; Collaborations; DNA Damage; DNA Repair; DNA Sequence; DNA replication fork; Development; Discipline; Ensure; Environment; Evolution; Feeling; Fellowship; Fertilization; Fostering; Funding Opportunities; Genetic; Genomic Instability; Genomics; Health; Heart; Hour; Human; Immune response; Immunoglobulin Genes; Industry; Invaded; Invertebrates; Life; Link; Location; Maine; Malignant Neoplasms; Mammalian Chromosomes; Mammals; Medicine; Modernization; Molecular; Mutagenesis; Mutation; Oral; Organism; Pathology; Play; Postdoctoral Fellow; Process; RNA; Replication Error; Research; Research Personnel; Resistance; Rural; Science; Scientist; Series; Site; Techniques; Therapeutic Intervention; Time; Underrepresented Minority; Viral; Woman; Work; Yeasts; adaptive immunity; cancer cell; career; chemotherapy; chromosome replication; commune; deep sequencing; environmental mutagens; fight against; graduate student; meetings; microorganism; next generation; pathogen; posters; programs; recruit; repaired; single molecule; social; symposium; trait

Project Summary / Abstract The 2022 Gordon Research Conference on Mutagenesis will explore cutting edge research into the mechanisms and consequences of changes in the genomic sequence of organisms from all branches of life. Alterations to the genetic blueprint of an organisms lies at the heart of many aspects of biology and pathology. Despite being a well-established conference, `Mutagenesis' remains a forefront topic, bridging the traditional boundaries of many fields. It drives the evolution of cancer, the escape of bacteria from killing by antibiotics as well as beneficial processes such as viral restriction and effective adaptive immunity. Importantly, common molecular mechanisms link these apparently diverse processes and a key aim of the conference will be to bring together fields that do not normally interact strongly. Further, the meeting will highlight a wide range of experimental approaches from deep sequencing to single molecule biophysics and bring together scientists of all career stages and backgrounds, from academia to industry. The GRC will comprise 28 invited speakers with 24 slots for talks to be selected from the abstracts as well as an interactive poster session. In addition, the GRS, which precedes the main conference will have further oral and poster presentation opportunities specifically for graduate students and post-docs, as well as a career panel discussion. A `power hour' in the main meeting will focus on the challenges facing women in science. We aim to foster an interactive, friendly environment in which ideas can be freely exchanged independently of background or seniority. To that end, the sessions and working meals will be supplemented with a vigorous social program to foster these interactions. The GRC program will be organized into nine morning and evening sessions entitled: (1) Fundamental mechanisms of mutagenesis (Keynote session); (2) DNA damage tolerance at the replication fork; (3) Visualizing mutagenic mechanisms; (4) Mutagenesis arising from replication errors; (5) RNA-dependent mutagenesis; (6) Repeat and barrier-induced mutagenesis; (7) Understanding mutagenic signatures in cancer and aging; (8) Environmental and endogenous mutagenesis and (9) Evolvability and adaptation. The GRC and GRS will thus promote exchange of the latest ideas and techniques in the broad field of mutagenesis and drive new ideas and cross-field collaborations while enhancing and promoting the careers of the next generation of scientists in this dynamic and exciting field.

项目摘要 /摘要 2022年戈登诱变研究会议将探索尖端研究 来自所有生物的基因组序列变化的机制和后果 生活的分支。对生物体的遗传蓝图的改变是许多人的核心 生物学和病理学方面。尽管是一个公认的会议，但“诱变” 仍然是一个最前沿的话题，桥接了许多领域的传统界限。它驱动进化 癌症，细菌逃避被抗生素杀死以及有益过程 作为病毒限制和有效的适应性免疫。重要的是，通用分子机制 将这些显然多样的过程和会议的关键目的链接在一起，将是结合在一起 通常不会相互作用的字段。此外，会议将突出广泛的 从深度测序到单分子生物物理学的实验方法，并将 从学术界到工业的各个职业阶段和背景的科学家。 GRC会 由28个邀请的演讲者组成24个插槽，以供摘要和 交互式海报会话。此外，主要会议之前的GRS 专门针对研究生和毕业后的其他口头和海报演示机会， 以及职业小组讨论。主要会议中的“电力时光”将重点放在 科学领域妇女面临的挑战。我们旨在促进一个互动，友好的环境 想法可以独立于背景或资历自由交换。为此， 会议和工作用餐将补充一个蓬勃的社会计划，以促进 这些相互作用。 GRC计划将组织到九点和晚上 题为：（1）诱变的基本机制（主题演讲）； （2）DNA 复制叉处的损伤耐受性； （3）可视化诱变机制； （4）诱变 由复制错误引起； （5）RNA依赖性诱变； （6）重复和屏障引起的 诱变； （7）了解癌症和衰老的诱变特征； （8）环境 和内源性诱变以及（9）的可变性和适应性。因此，GRC和GRS将 促进在诱变和动力的广泛领域的最新思想和技术的交流 新的想法和跨场合作协作，同时增强和促进下一个职业 在这个动态而令人兴奋的领域中的科学家产生。