Training and Research on Arboviruses and Zoonoses In Nigeria and Sierra Leone (TRAIN)

尼日利亚和塞拉利昂虫媒病毒和人畜共患病培训和研究 (TRAIN)

• 批准号: 10461490
• 负责人: Nathan Yakubu Shehu
• 金额: $ 25.24万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461490
• 关键词: Address; Africa; African; Americas; Animal Model; Arboviruses; Asia; Blood Circulation; Chikungunya fever; Clinical; Country; Dengue; Diagnostic; Disease; Disease Outbreaks; Ebola virus; Education; Emerging Communicable Diseases; Enrollment; Ensure; Epidemic; Generations; Health; Hemorrhage; Hemorrhagic Fever with Renal Syndrome; Human; Laboratory Technicians; Lassa virus; Medical; Methods; Molecular; National Institute of Allergy and Infectious Disease; Nigeria; Outcome; Pathogenesis; Phase; Play; Public Health; Public Health Education; Recording of previous events; Research; Research Training; Risk; Role; Science; Scientist; Sierra Leone; Site; Source; Techniques; Texas; Training; Training Activity; Training Programs; Universities; Viral; Viral Hemorrhagic Fevers; Virus; Virus Diseases; Yellow Fever; Zoonoses; burden of illness; data management; design; doctoral student; experience; multidisciplinary; prevent; programs; transmission process; zika fever

ABSTRACT Emerging viral diseases comprise several of the greatest global risks to human health, and West Africa is a source and epicenter for several. These include arthropod-borne viruses (arboviruses), such as chikungunya, Zika, and yellow fever with African origin and both ancient and recent histories of spread to Asia and the Americas to initiate massive epidemics. Dengue also increasingly recognized in Africa as a major public health problem. Zoonotic African hemorrhagic viruses also caused unprecedented outbreaks during the past decade. In 2014, the first West African epidemic of hemorrhagic fever attributed to Ebola virus spread to several countries including Sierra Leone, representing by far the most devastating filoviral outbreak on record with over 11,000 fatalities. Lassa virus, causing an estimated 100,000-300,000 hemorrhagic fever cases in Africa annually, produced an unprecedented 2018-2019 epidemic in Nigeria. The mechanisms whereby these zoonotic viruses emerge remain obscure along with understanding of their true disease burden and varied clinical disease and sequelae outcomes. To address these challenges, we will develop a new generation of West African scientists to predict, prevent and contain emerging viral diseases through multidisciplinary scientific and public health training. Leveraging our West African Center for Emerging Infectious Diseases (WAC-EID, NIAID U01AI151801), outstanding research leaders in West Africa, and the exceptional breadth of expertise in emerging viral diseases at the University of Texas Medical Branch (UTMB), we will provide multidisciplinary training for young scientists from two leading universities: Njala University in Sierra Leone and Jos University in Nigeria. The aims of Training and Research on Arboviruses and Zoonoses In Nigeria and Sierra Leone (TRAIN) include: 1. Provide general on-site training at Njala and Jos Universities to Master’s/PhD students enrolled in the local graduate programs; 2. Provide specialized training at UTMB on the most advanced methods and techniques for expertise transfer to Sierra Leone and Nigeria; 3. Provide on-site research training at Njala and Jos Universities to ensure successful local implementation of the program, which will include education of laboratory technicians/managers among others; 4. Integrate trainees into the WAC-EID’s research programs to gain hands-on experience in surveillance activities, diagnostics and data management. Five trainees per year will participate in short-, medium-, and long- term training phases at UTMB and in W. Africa. Training activities will include didactic courses, online modules, field training, molecular/virological techniques including the study of animal models and pathogenesis, biosafety training, and lab management education. Upon the completion of our training program, these young scientists will play critical roles in surveillance to better understand the circulation of emerging viruses in the region, mechanisms of emergence, virus discovery, epidemic transmission, pathogenesis, and countermeasures to mitigate emerging viral threats. The local training programs are designed to be sustainable, and the 3-way research and training partnerships will broadly benefit science and public health throughout the region.

摘要 新出现的病毒性疾病构成了对人类健康的几个最大的全球风险，而西非是一个 几个城市的震源和震中。这些病毒包括节肢动物传播的病毒(虫媒病毒)，如基孔肯雅病毒， 寨卡病毒和起源于非洲的黄热病，以及古代和近代传播到亚洲和美洲的历史 引发大规模的流行病。在非洲，登革热也日益被认为是一个重大的公共卫生问题。 在过去十年中，非洲人畜共患出血性病毒也造成了前所未有的疫情。2014年， 西非首例埃博拉病毒引发的出血热疫情蔓延至多个国家 包括塞拉利昂，是有记录以来最具破坏性的丝状病毒疫情，有超过11,000人 死亡事故。拉萨病毒，估计每年在非洲造成10万至30万出血热病例， 导致了2018-2019年在尼日利亚史无前例的疫情。这些人畜共患病病毒 随着对他们真实的疾病负担和各种临床疾病的了解，浮现仍然模糊不清 后遗症后果。为了应对这些挑战，我们将培养新一代西非科学家 通过多学科的科学和公共卫生来预测、预防和控制新出现的病毒疾病 训练。利用我们的西非新发传染病中心(WAC-EID，NIAID U01AI151801)， 西非杰出的研究领导者，以及在新出现的病毒疾病方面的非凡专业知识 在德克萨斯大学医学分校(UTMB)，我们将为年轻科学家提供多学科培训 来自两所顶尖大学：塞拉利昂的贾拉大学和尼日利亚的乔斯大学。培训的目的 尼日利亚和塞拉利昂虫媒病毒和人畜共患病的研究包括：1.提供一般情况 在Njala和Jos大学对参加当地研究生课程的硕士/博士学生进行现场培训； 2.在UTMB提供关于最先进方法和技术的专门培训，以便将专业知识转移到 塞拉利昂和尼日利亚；3.在Njala和Jos大学提供现场研究培训，以确保成功 在当地实施该方案，其中将包括对实验室技术人员/管理人员的教育 其他；4.将受训人员纳入WAC-EID的研究计划，以获得实际监控经验 活动、诊断和数据管理。每年将有五名学员参加短期、中期和长期培训 UTMB和西非的学期培训阶段。培训活动将包括授课课程、在线模块、 实地培训、分子/病毒学技术，包括动物模型和致病机理研究、生物安全 培训和实验室管理教育。在完成我们的培训计划后，这些年轻的科学家 将在监测方面发挥关键作用，以更好地了解新出现病毒在该地区的传播情况， 疫情发生机制、病毒发现、流行传播、发病机制及对策 缓解新出现的病毒威胁。当地的培训计划被设计为可持续的，三方 研究和培训伙伴关系将广泛惠及整个区域的科学和公共卫生。