Research Education Component Rio Grande Valley AD-RCMAR

计划摘要-研究及教育部分 阿尔茨海默病（AD）造成的巨大痛苦、残疾和寿命损失， 相关的条件代表着全球性的危机。事实上，AD和相关疾病（ADRD）构成了第二种 高收入国家残疾人年数的主要原因-833万人，占年初至今的近1/10 所有原因。这些事实激励和推动研究，并培养创造力和创新，以预防和治疗 AD，特别是在少数群体，特别是西班牙裔，这是由它的影响。 少数民族学者在科学研究中的代表性不足，特别是在ADRD中 研究的重点是AD对西班牙裔美国人造成过高影响的原因和潜在补救措施。的 该大学拟议的少数民族老龄化研究AD研究中心（AD-RCMAR）的主要目标 德克萨斯州格兰德河谷（UTRGV）的目标是识别、培训和指导一批多样化的优秀人才， 代表性不足的群体中的妇女，她们将成为社会和行为科学进步的领导者， 可转化为改善AD和相关疾病（ADRD）影响的研究，特别是在老龄化中 西班牙裔和其他少数民族。为了实现这一目标，研究教育组件（REC）的AD- UTRGV的RCMAR将利用经验丰富，成功， 这些领域的跨学科研究人员和领导者，以实现以下具体目标：（1）支持 创新的，高影响力的多学科试点项目，导致成功申请校外 美国国立卫生研究院支持少数民族科学家的创新研究和进一步职业发展 ADRD研究（例如，R和K奖）;（2）确定、参与并提供高质量的培训， 个性化的职业发展支持，以优秀的教师代表性不足的少数群体谁是 关注ADRD研究和翻译，以改善少数民族的健康;（3）开发和培训AD-RCMAR 科学家在研究特定的技能和知识，他们将需要成为独立的研究人员 致力于少数民族人群的AD。为了实现这些目标，我们建立了一个领导团队， 在研究教育、规划和评估指导以及领导 合作的跨学科研究工作，旨在改善少数民族和西班牙裔的健康，在有针对性的 我们已考虑到所有需要的行政和后勤支助。学员 学员将参与并受益于丰富的沉浸式体验， 解决社会和生物行为ADRD的贡献者和贫困的影响，主要是西班牙裔 美国-墨西哥边境地区的RGV。他们的培训和努力的部分目的是在现有的基础上， 社区医疗保健和社会支持网络和资源，与UTRGV和 其AD-RCMAR的领导团队。拟议的区域环境中心将提供一个有效和具有成本效益的结构， UTRGV AD-RCMAR吸引和支持跨机构的教育和研究企业， 推进减少ADRD健康差距的目标。

Project Summary - Research Education Component The overwhelming burden of suffering, disability, and years of life lost due to Alzheimer´s disease (AD) and related conditions represent a global crisis. Indeed, AD and related disorders (ADRD) constitute the second leading cause of years lived with disability (YLDs) in high income countries – 8.33 million, nearly 1/10 of YTD from all causes. These facts inspire and drive research and foster creativity and innovation to prevent and cure AD, particularly among minority groups and especially Hispanics, that are disproportionally affected by it. Scholars from ethnic minority groups are underrepresented in scientific research, particularly in ADRD research focused on the causes and potential remedies of the unduly high impacts of AD on Hispanics. The primary goal of the proposed AD-Research Center for Minority Aging Research (AD-RCMAR) at the University of Texas Rio Grande Valley (UTRGV) is to identify, train and mentor a diverse group of outstanding men and women of underrepresented groups who will become leaders of scientific advances in social and behavioral research that is translatable to ameliorating impacts of AD and related disorders (ADRD), particularly in aging Hispanics and other minorities. To accomplish this goal, the Research Education Component (REC) of the AD- RCMAR at UTRGV will leverage the research expertise and resources of experienced, successful, interdisciplinary investigators and leaders in these fields to achieve the following specific aims: (1) support innovative, high-impact multidisciplinary pilot projects that lead to successful applications for extramural support by NIH of innovative research and further career development for scientists in minorities-focused ADRD research (e.g., R and K awards); (2) identify, engage, and provide high-quality training and individualized career development support to outstanding faculty of underrepresented minority groups who are focused on ADRD research and translation to improve minorities' health; (3) develop and train AD-RCMAR Scientists in research-specific skills and knowledge they will need to become independent researchers dedicated to AD in minority populations. To accomplish these goals, we have built a leadership team with extensive experience in research education, planning and evaluation of mentoring, and leadership of collaborative interdisciplinary research efforts aimed at improving minorities' and Hispanics' health in targeted geographic populations, and we have accounted for all needed administrative and logistic support. Trainees and mentees will engage in and benefit from a rich immersive experience in developing collaborative research addressing social and bio-behavioral ADRD contributors and impacts in the poverty-stricken, primarily Hispanic US-Mexico border region of the RGV. Their training and efforts will be aimed in part at building upon existing community healthcare and social support networks and resources that have extensive links to UTRGV and the leadership team of its AD-RCMAR. The proposed REC will provide an effective and cost-efficient structure for the UTRGV AD-RCMAR to attract and support a cross-institution education and research enterprise that will advance the goals reducing health disparities for ADRD.