Core C - Comparative Organismal Energetics Core

项目摘要--比较组织能量学核心 比较组织能量学核心(Organismal Core)提供以下方面的专门知识 方法学的发展和利用、最先进的仪器和动物的选择 促进理解能量学对生物衰老的贡献的模型，包括营养， 影响衰老研究的遗传和生化干预。组织核心是一种独特的资源 对于调查人员来说，校园内其他地方没有服务和资源，更广泛的人也可以获得 (非UAB)研究社区。组织核心非常适合测量能量获取、存储、 以及在包括线虫、水蚤、果蝇、斑马鱼和啮齿动物在内的各种动物模型中的应用， 从而补充了UAB Nathan休克中心(NSC)的总体使命和主题。具体的 核心计划的目标如下： 1.在比较动物模型中提供能量学和身体成分方面的专业知识 衰老； 2.为身体成分的测定提供最先进的仪器和方法 在整个生命周期内(双能X射线吸收法、定量磁共振和微 计算机断层扫描)； 3.为测定能量平衡提供最先进的仪器和方法 整个寿命(食物摄入量、能量消耗、能量平衡和活动量)； 4.提供最先进的工具和方法来评估与健康相关的 跨越寿命和物种的行为； 5.制定新的方法，在当前和未来需要时评估能量/身体成分 用于衰老研究的新生物； 6.提供关于比较有机体能量学的程序和陷阱的教育和培训(两者 UAB内部和外部)。

Project Summary – Comparative Organismal Energetics Core The Comparative Organismal Energetics Core (Organismal Core) provides specialized expertise in the development and utilization of methodologies, state-of-the-art instrumentation and the selection of animal models to facilitate understanding the contribution of energetics to biological aging, including nutritional, genetic, and biochemical interventions that impact aging research. The Organismal Core is a unique resource for investigators, with services and resources not available elsewhere on campus and available to the broader (non-UAB) research community. The Organismal Core is ideally suited to measure energy acquisition, storage, and utilization in a variety of animal models including C. elegans, Daphnia, Drosophila, zebrafish, and rodents, thereby complementing the overall mission and theme of the UAB Nathan Shock Center (NSC). The Specific Aims of the Core are as follows: 1. To provide expertise in the area of energetics and body composition in comparative animal models of aging; 2. To provide state-of-the-art instrumentation and methodology for the determination of body composition across the lifespan (dual energy X-ray absorptiometry, quantitative magnetic resonance, and micro- computed tomography); 3. To provide state-of-the-art instrumentation and methodology for the determination of energy balance across the lifespan (food intake, energy expenditure, energy balance, and activity); 4. To provide state-of-the-art instrumentation and methodology for evaluating healthspan-associated behaviors across lifespan and species; 5. To develop new methodologies for assessing energetics/body composition where needed in current and novel organisms for aging research; 6. To provide education and training on procedures and pitfalls in comparative organismal energetics (both internal and external to UAB).