Animal Physiology Core

动物生理学核心

• 批准号: 10183230
• 负责人: TIMOTHY R NAGY
• 金额: $ 17.78万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10183230
• 关键词: Animal Model; Animals; Area; Biology; Blood Pressure; Blood Vessels; Body Composition; Body Temperature; Cardiometabolic Disease; Cardiovascular Physiology; Cardiovascular system; Chemicals; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Data; Diabetes Mellitus; Dual-Energy X-Ray Absorptiometry; Eating; Echocardiography; Equipment; Functional disorder; Funding; Gamma Rays; Generations; Genetically Modified Animals; Genotype; Glucose Clamp; Goals; Grant; Image; In Vitro; Indirect Calorimetry; Knock-in; Knock-out; Magnetic Resonance; Magnetic Resonance Imaging; Metabolic; Metabolic Diseases; Metabolism; Methodology; Methods; Miniaturization; Nature; Output; Phenotype; Physiology; Positron-Emission Tomography; Preparation; Process; Productivity; Publications; Reagent; Research; Research Personnel; Resources; Rodent; Rodent Model; Roentgen Rays; Services; Technology; Testing; Training; Transgenic Animals; Transgenic Organisms; Translational Research; Vascular Diseases; base; bioluminescence imaging; blood glucose regulation; cardiometabolism; cost effectiveness; cost efficient; design; energy balance; experimental study; fluorescence imaging; glucose tolerance; human disease; in vivo; instrumentation; insulin tolerance; metabolic rate; microCT; molecular imaging; monitoring device; single photon emission computed tomography; tool; translational pipeline

The Animal Physiology Core (APC) brings together four experts in the areas of integrative physiology, cardiovascular physiology, imaging, and animal models who serve as a core resource for the study of diabetes using rodent models. The methods and services reflect the DRC theme that diabetes is both a metabolic and vascular disease. The overall goal of the APC is to provide easy access to highly-specialized equipment and expertise to augment diabetes and cardiometabolic research quality and cost effectiveness. The APC incorporates expertise and current technology for both metabolism and vascular assessment, brought together in one core for combined applications by the user base. The Specific Aims of the APC are to: 1. Provide expertise in the use of animal models for diabetes and cardiometabolic disease research; 2. To provide state-of-the-art instrumentation and methodology for the determination of body composition, energy balance, glucose homeostasis, cardiovascular assessment, molecular imaging, and genetically modified animal models; 3. To provide cost-efficient services to Core users; and 4. To promote interactions among investigators and to provide training in animal models and phenotyping methods. Since the DRC APC was founded in 2008, the track record of utilization and productivity has been outstanding and is growing. The high quality, breadth, and cutting-edge nature of the Core’s technologies, and responsiveness to the evolving needs of our investigators, have resulted in high rates of utilization by the DRC research base. By promulgating high-quality services in small animal phenotyping, the Core is an important strength for assuring that research is promoted across the full spectrum of translational research. The productivity numbers and data in the core utilization table speak for themselves. During the last grant cycle, the APC has been extremely active in supporting diabetes and cardiovascular research. The APC has supported 145 funded projects from 77 UAB investigators. The data provided by the core became the basis of numerous federal grants and led to many high-quality publications.

动物生理学核心（APC）汇集了四位综合领域的专家， 生理学、心血管生理学、成像和动物模型， 使用啮齿动物模型研究糖尿病的资源。方法和服务反映了 DRC的主题是糖尿病既是一种代谢性疾病，也是一种血管性疾病。的总体目标 APC将提供高度专业化的设备和专业知识， 糖尿病和心脏代谢研究质量和成本效益。APC包含 代谢和血管评估的专业知识和现有技术， 一起在一个核心中，用于用户群的组合应用。 APC的具体目标是： 1.提供使用糖尿病和心脏代谢疾病动物模型的专业知识 研究; 2.提供最先进的仪器和方法来测定身体 组成，能量平衡，葡萄糖稳态，心血管评估， 分子成像和转基因动物模型; 3.为核心用户提供具有成本效益的服务;以及 4.促进研究者之间的互动，并提供动物模型方面的培训， 表型分析方法。 自2008年成立以来，DRC APC的利用率和生产率记录 一直很优秀，而且还在成长。的高质量、广度和前沿性， 核心的技术，以及对我们调查人员不断变化的需求的响应， 导致DRC研究基地的高利用率。通过发布高质量的 在小动物表型鉴定服务中，核心是确保 在翻译研究的整个范围内促进研究。生产力 核心利用率表中的数字和数据不言自明。在上一个赠款周期， APC一直非常积极地支持糖尿病和心血管研究。的 进通会支助了77名律师协会调查员的145个资助项目。提供的数据 核心方案成为许多联邦赠款的基础，并导致许多高质量的出版物。