Core C: Comparative Organismal Energetics Core

核心 C：比较有机体能量学核心

• 批准号: 8958640
• 负责人: TIMOTHY R NAGY
• 金额: $ 8.67万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8958640
• 关键词: Aging; Animal Model; Area; Body Composition; Budgets; Caenorhabditis elegans; Country; Daphnia; Doctor of Philosophy; Drosophila genus; Dual-Energy X-Ray Absorptiometry; Eating; Energy Metabolism; Laboratories; Longevity; Magnetic Resonance; Measures; Methodology; Mission; Organism; Procedures; Research; Research Personnel; Resources; Rodent; Shock; Training and Education; X-Ray Computed Tomography; Zebrafish; comparative; energy balance; instrumentation; novel

The Comparative Organismal Energetics Core (COEC) provides specialized expertise in the use of animal models, methodologies, and state-of-the-art instrumentation to facilitate energetics and aging research. The COEC provides a unique resource for investigators, with capabilities to perform complete energy budget analysis under environmental conditions of the users' choosing. The core is ideally suited to measure energy acquisition, storage, and utilization in a variety of animal models including C. elegans, Daphnia, Drosophila, Zebrafish, and rodents, and synergizes nicely with the overall mission of the UAB Nathan Shock Center (NSC). Interactions with the other Cores in the UAB NSC will be extensive. The Specific Aims of the Core are: 1. To provide expertise in the area of energetics and body composition in comparative animal models of aging; 2. To provide state-of-the-art instrumentation and methodology for the determination of body composition across the lifespan (dual energy X-ray absorptiometry, quantitative magnetic resonance, and micro- computed tomography); 3. To provide state-of-the-art instrumentation and methodology for the determination of energy balance across the lifespan (food intake, energy expenditure, and activity); 4. Develop new methodologies for assessing energetics/body composition in novel organisms. 5. Provide education and training on procedures and pitfalls in comparative organismal energetics (both internal and external to UAB)

比较有机能量学核心（COEC）提供了使用动物能量学的专业知识。 模型，方法和最先进的仪器，以促进能量学和老龄化研究。的 COEC为调查人员提供了独特的资源，能够执行完整的能源预算 用户选择的环境条件分析。核心非常适合测量能量 在包括C.线虫，水蚤，果蝇， 斑马鱼，和啮齿动物，并协同很好地与整体使命的UAB内森休克中心（NSC）。 与UAB NSC中其他核心的互动将是广泛的。 核心的具体目标是： 1.提供能量学和身体组成领域的专业知识，比较动物模型， 熟化; 2.提供最先进的仪器和方法来测定身体成分 在整个生命周期内（双能X射线吸收法，定量磁共振，和微- 计算机断层扫描）; 3.提供最先进的仪器和方法来确定能量平衡 整个生命周期（食物摄入，能量消耗和活动）; 4.开发评估新生物体能量学/身体组成的新方法。 5.提供关于比较生物能量学的程序和陷阱的教育和培训（包括 UAB内部和外部）