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Neurophysiology of social processing and underlying perceptual deficits in schizophrenia

精神分裂症的社会处理和潜在知觉缺陷的神经生理学

基本信息

批准号：
10464268
负责人：
Emily Joyce Doyle Przysinda
金额：
$ 5.18万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10464268
关键词：
Address Area Behavior Biological Markers Brain Brain region Clinical Cognition Complex Data Disease Electroencephalography Elements Event Frequencies Functional Magnetic Resonance Imaging Future Gold Hallucinations Healthcare Imaging Techniques Impairment Individual Language Life Linear Models Linguistics Measures Medical Mentorship Methods Mind Participant Patient Care Patient-Focused Outcomes Patients Perception Persons Pharmaceutical Preparations Physicians Process Property Quality of life Research Role Schizophrenia Scientist Sensory Social Interaction Speech Speech Acoustics Stimulus Symptoms Techniques Time Training Training Programs care outcomes career cost experience functional disability functional magnetic resonance imaging/electroencephalography imaging modality improved information processing interest language processing mental state movie neural correlate neural model neural network neuroimaging neurophysiology neurotransmission recruit relating to nervous system response severe mental illness side effect social social communication social deficits social influence social norm success temporal measurement theories

项目摘要

ABSTRACT Schizophrenia (SZ) is a debilitating and complex disorder with many symptoms, and current treatments often don't address the totality of the illness. One symptom that is often overlooked is social processing deficits, and these difficulties can cause significant functional impairment for these patients. Patients with SZ are also known to have subtle perceptual deficits, and it is possible that these may be related to social processing deficits. More research examining how these social and perceptual processing difficulties manifest in the brain is needed, especially research utilizing naturalistic stimuli that mimic real life. Here, we use episodes of the comedy TV show, The Office, as our stimulus because it contains a rich variety of social interactions, including some that may be violating social norms (i.e., awkward events). These episodes are also rich in speech content that will allow us to examine language at many different hierarchical levels of processing. We will use two complementary neuroimaging imaging modalities to examine social brain network differences in patients with SZ and how more basic perceptual language processing deficits may be influencing these measures. Our analysis will allow us to quantify specific stimulus parameters related to social understanding, like awkwardness, and language processing, such as low-level envelope tracking and higher-level linguistic meaning. We will then quantify how the neural signal reflects these stimulus parameters using linear methods. For Aim 1, we will use functional magnetic resonance imaging (fMRI) techniques to characterize neural dynamics of social and perceptual processing deficits in SZ. We will first assess the neural tracking of language features during the episodes utilizing a general linear model approach (GLM). Next, we will quantify group differences in how the brain tracks with social parameters, like awkwardness. We will also characterize neural dynamics between important nodes in the social processing brain network. For Aim 2 will use electroencephalography (EEG) to characterize neural tracking of speech features with more temporal precision compared to fMRI. We will also examine how social features are reflected in the neural signal and characterize functional connectivity of social processing regions within specific frequency ranges. We predict that across both aims, the brains of patients with SZ will track less with the perceptual and social features of the stimulus, and that any perceptual deficits may be contributing to social deficits. We aim to recruit the same participants for aim 1 and 2, so we can capitalize on the strengths of both methods and examine how these measures may be providing complementary information about language and social processing deficits. We hope that this research can be used to inform future research for biomarkers of SZ and ultimately improve healthcare outcomes for patients with SZ.

摘要