Neurophysiology of social processing and underlying perceptual deficits in schizophrenia

精神分裂症的社会处理和潜在知觉缺陷的神经生理学

• 批准号: 10594421
• 负责人: Emily Joyce Doyle Przysinda
• 金额: $ 5.25万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594421
• 关键词: Address; Area; Behavior; Biological Markers; Brain; Brain region; Cognition; Complex; Data; Disease; Electroencephalography; Elements; Event; Frequencies; Functional Magnetic Resonance Imaging; Future; Hallucinations; Healthcare; Imaging Techniques; Impairment; Individual; Language; Life; Linear Models; Linguistics; Measures; Medical; Mentorship; Methods; Mind; Participant; Patient Care; Patient-Focused Outcomes; Patients; Perception; Persons; Pharmaceutical Preparations; Physicians; Process; Property; Quality of life; Research; Role; Schizophrenia; Scientist; Sensory; Social Interaction; Speech; Speech Acoustics; Stimulus; Symptoms; Techniques; Time; Training; Training Programs; care outcomes; career; clinical training; cost; experience; functional disability; functional magnetic resonance imaging/electroencephalography; imaging modality; improved; information processing; interest; language processing; mental state; movie; neural; neural correlate; neural model; neural network; neuroimaging; neurophysiology; neurotransmission; recruit; response; severe mental illness; side effect; social; social communication; social deficits; social influence; social norm; success; temporal measurement; theories

ABSTRACT Schizophrenia (SZ) is a debilitating and complex disorder with many symptoms, and current treatments often don't address the totality of the illness. One symptom that is often overlooked is social processing deficits, and these difficulties can cause significant functional impairment for these patients. Patients with SZ are also known to have subtle perceptual deficits, and it is possible that these may be related to social processing deficits. More research examining how these social and perceptual processing difficulties manifest in the brain is needed, especially research utilizing naturalistic stimuli that mimic real life. Here, we use episodes of the comedy TV show, The Office, as our stimulus because it contains a rich variety of social interactions, including some that may be violating social norms (i.e., awkward events). These episodes are also rich in speech content that will allow us to examine language at many different hierarchical levels of processing. We will use two complementary neuroimaging imaging modalities to examine social brain network differences in patients with SZ and how more basic perceptual language processing deficits may be influencing these measures. Our analysis will allow us to quantify specific stimulus parameters related to social understanding, like awkwardness, and language processing, such as low-level envelope tracking and higher-level linguistic meaning. We will then quantify how the neural signal reflects these stimulus parameters using linear methods. For Aim 1, we will use functional magnetic resonance imaging (fMRI) techniques to characterize neural dynamics of social and perceptual processing deficits in SZ. We will first assess the neural tracking of language features during the episodes utilizing a general linear model approach (GLM). Next, we will quantify group differences in how the brain tracks with social parameters, like awkwardness. We will also characterize neural dynamics between important nodes in the social processing brain network. For Aim 2 will use electroencephalography (EEG) to characterize neural tracking of speech features with more temporal precision compared to fMRI. We will also examine how social features are reflected in the neural signal and characterize functional connectivity of social processing regions within specific frequency ranges. We predict that across both aims, the brains of patients with SZ will track less with the perceptual and social features of the stimulus, and that any perceptual deficits may be contributing to social deficits. We aim to recruit the same participants for aim 1 and 2, so we can capitalize on the strengths of both methods and examine how these measures may be providing complementary information about language and social processing deficits. We hope that this research can be used to inform future research for biomarkers of SZ and ultimately improve healthcare outcomes for patients with SZ.

抽象的 精神分裂症（SZ）是一种具有多种症状的令人衰弱和复杂的疾病，当前治疗通常 不要解决疾病的整体。经常被忽视的一种症状是社会处理赤字，以及 这些困难会给这些患者带来重大功能障碍。 SZ患者也是 已知有微妙的知觉缺陷，并且可能与社会处理有关 缺陷。更多的研究研究了这些社会和感知处理困难如何在大脑中表现出来 需要，尤其是利用模仿现实生活的自然主义刺激的研究。在这里，我们使用了 喜剧电视节目《办公室》作为我们的刺激，因为它包含各种各样的社交互动，包括 有些可能违反了社会规范（即尴尬的事件）。这些情节也很丰富 将使我们能够在许多不同层次的处理层面上检查语言的内容。我们将使用 两种互补的神经影像学成像方式，以检查患者的社交大脑网络差异 SZ以及更基本的感知语言处理缺陷如何影响这些措施。我们的 分析将使我们能够量化与社会理解相关的特定刺激参数 尴尬和语言处理，例如低级信封跟踪和更高级别的语言 意义。然后，我们将使用线性方法量化神经信号如何反映这些刺激参数。 对于AIM 1，我们将使用功能磁共振成像（fMRI）技术来表征神经 SZ中社会和感知处理缺陷的动态。我们将首先评估 在情节中使用通用线性模型方法（GLM）的语言特征。接下来，我们将量化 大脑如何使用社交参数跟踪的群体差异，例如尴尬。我们还将描述 社会处理大脑网络中重要节点之间的神经动态。 AIM 2将使用 脑电图（EEG）表征语音特征的神经跟踪，具有更高的精度 与fMRI相比。我们还将研究如何在神经信号中反映社交特征并表征 特定频率范围内社会处理区域的功能连通性。我们预测 这两个目的都是，SZ患者的大脑将通过刺激的感知和社会特征，较少的跟踪， 任何感知缺陷都可能导致社会缺陷。我们的目标是招募相同的参与者 对于AIM 1和2，因此我们可以利用这两种方法的优势，并检查这些措施如何 提供有关语言和社会处理缺陷的互补信息。我们希望这个 研究可用于为SZ生物标志物的未来研究提供信息，并最终改善医疗保健 SZ患者的结果。