Elastic, Degradable Vascular Grafts with Helical Microfibers
具有螺旋微纤维的弹性、可降解血管移植物
基本信息
- 批准号:10463745
- 负责人:
- 金额:$ 68.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-15 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAgingAnimal ModelArchitectureArteriesArteriovenous fistulaAtherosclerosisAutologousAutologous TransplantationAutomobile DrivingBiologicalBioreactorsBlood VesselsBlood flowBypassCaliberCardiovascular DiseasesCardiovascular systemCarotid ArteriesCellsClinicalCoronaryDataDepositionDevelopmentDevicesDiabetes MellitusElderlyExtracellular MatrixFiberGoalsGoldHarvestHumanImmune responseImpairmentImplantIn SituInflammationInterleukin-10InterventionKidney FailureKneeKnowledgeLimb structureModelingMorbidity - disease rateNon-Insulin-Dependent Diabetes MellitusOperative Surgical ProceduresPathologyPatientsPerformanceProcessPropertyProteinsRattusResearchRodentSeedsSheepSiteSourceSpeedSprague-Dawley RatsStromal CellsSystemic diseaseTechnologyTestingVascular GraftVein graftage effectagedbiodegradable scaffoldcell motilityclinical translationcomorbiditycontrolled releasecostcytokinedesigndiabeticeffectiveness evaluationelastomericendothelial stem cellgraft failuregraft functionimprovedinfection riskinsightnon-diabeticpatient populationpre-clinicalreconstructionscaffoldstem cell populationwound healing
项目摘要
Elastic, Degradable Vascular Grafts with Helical Microfibers
When an artery occludes, rerouting blood flow with a vascular graft can save lives or limbs.
Autologous grafts are the preferred conduit for replacing small-diameter vessels. However, not all
patients have suitable donor vessels, and the wound healing complications associated with the
harvest can be severe. Synthetic grafts can be used but the foreign material does not degrade or
integrate with the host, leading to graft failure and risk of infection. These grafts function best in
large caliber arterial reconstruction but perform poorly in smaller arteries such as in the coronary
and below the knee arteries. We will overcome this challenge by using a degradable graft made of
elastomeric microfibers arranged in helices mimicking extracellular matrix fibers in the artery. Our
preliminary data in rats show these grafts remodel into compliant, elastic vascular conduits
resembling the native arteries. The proposed research will address two key questions for clinical
translation: 1) will host cells fully populate the long grafts needed for human applications and 2)
will the same transformation occur in aged patients and those with systemic diseases such as
diabetes? Correspondingly, Specific Aim 1 will investigate host remodeling of 7-inch-long
interposition grafts in a sheep carotid artery. Aim 2 will assess graft remodeling in Zucker Diabetic
Sprague-Dawley rats, a new polygenetic model of Type 2 diabetes. Aim 3 will evaluate the
effectiveness of controlled release of cytokines in the graft to overcome the limitations caused by
aging. Upon completion of this project, we expect to have a graft design ready for clinical
translation. The knowledge gained will have impact beyond vascular substitutes in the
development of other cardiovascular devices.
弹性可降解螺旋超细纤维血管移植物
当动脉闭塞时,用血管移植物改变血流路线可以挽救生命或肢体。
自体移植物是替代小直径血管的首选管道。然而,并不是所有的
患者有合适的供体血管,伤口愈合并发症与
收成可能会很严重。可以使用合成移植物,但异物不会降解或
与宿主结合,导致移植物失败和感染风险。这些移植物在
大口径动脉重建,但在较小的动脉中表现不佳,如冠状动脉
膝盖动脉以下。我们将通过使用可降解的移植物来克服这一挑战
弹性微纤维呈螺旋状排列,模拟动脉内的细胞外基质纤维。我们的
在大鼠身上的初步数据显示,这些移植物重建为顺应性的、有弹性的血管管道
类似于天然动脉的。拟议的研究将解决临床上的两个关键问题
译文:1)宿主细胞是否会完全填充人类应用所需的长移植物和2)
同样的转变会发生在老年患者和患有系统性疾病的患者中吗
糖尿病?相应地,特定目标1将调查7英寸长的主机重塑
绵羊颈动脉内的间置移植物。AIM 2将评估Zucker糖尿病患者的移植物重塑
一种新的2型糖尿病多基因模型--SD大鼠。AIM 3将评估
在移植物中控制释放细胞因子的有效性,以克服
衰老。在这个项目完成后,我们预计将有一个移植物设计准备用于临床
翻译。所获得的知识将产生超越血管替代品的影响
开发其他心血管设备。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Edith Tzeng其他文献
Edith Tzeng的其他文献
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{{ truncateString('Edith Tzeng', 18)}}的其他基金
Metformin BenefIts Lower Extremities with Intermittent Claudication (MOBILE_IC)
二甲双胍有益于间歇性跛行的下肢 (MOBILE_IC)
- 批准号:
10426266 - 财政年份:2022
- 资助金额:
$ 68.33万 - 项目类别:
Metformin BenefIts Lower Extremities with Intermittent Claudication (MOBILE_IC)
二甲双胍有益于间歇性跛行的下肢 (MOBILE_IC)
- 批准号:
10257312 - 财政年份:2022
- 资助金额:
$ 68.33万 - 项目类别:
Elastic, Degradable Vascular Grafts with Helical Microfibers
具有螺旋微纤维的弹性、可降解血管移植物
- 批准号:
10887286 - 财政年份:2021
- 资助金额:
$ 68.33万 - 项目类别:
Elastic, Degradable Vascular Grafts with Helical Microfibers
具有螺旋微纤维的弹性、可降解血管移植物
- 批准号:
10280660 - 财政年份:2021
- 资助金额:
$ 68.33万 - 项目类别:
Elastic, Degradable Vascular Grafts with Helical Microfibers
具有螺旋微纤维的弹性、可降解血管移植物
- 批准号:
10685260 - 财政年份:2021
- 资助金额:
$ 68.33万 - 项目类别:
Research Supplements to Promote Diversity in Vascular Graft Research
促进血管移植研究多样性的研究补充
- 批准号:
10619171 - 财政年份:2021
- 资助金额:
$ 68.33万 - 项目类别:
Xanthine oxidoreductase in impaired diabetic wound healing.
黄嘌呤氧化还原酶在糖尿病伤口愈合受损中的作用。
- 批准号:
10477928 - 财政年份:2016
- 资助金额:
$ 68.33万 - 项目类别:
Xanthine oxidoreductase in impaired diabetic wound healing.
黄嘌呤氧化还原酶在糖尿病伤口愈合受损中的作用。
- 批准号:
9138069 - 财政年份:2016
- 资助金额:
$ 68.33万 - 项目类别:
Xanthine oxidoreductase in impaired diabetic wound healing.
黄嘌呤氧化还原酶在糖尿病伤口愈合受损中的作用。
- 批准号:
10038744 - 财政年份:2016
- 资助金额:
$ 68.33万 - 项目类别:
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