Elastic, Degradable Vascular Grafts with Helical Microfibers
具有螺旋微纤维的弹性、可降解血管移植物
基本信息
- 批准号:10463745
- 负责人:
- 金额:$ 68.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-15 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAgingAnimal ModelArchitectureArteriesArteriovenous fistulaAtherosclerosisAutologousAutologous TransplantationAutomobile DrivingBiologicalBioreactorsBlood VesselsBlood flowBypassCaliberCardiovascular DiseasesCardiovascular systemCarotid ArteriesCellsClinicalCoronaryDataDepositionDevelopmentDevicesDiabetes MellitusElderlyExtracellular MatrixFiberGoalsGoldHarvestHumanImmune responseImpairmentImplantIn SituInflammationInterleukin-10InterventionKidney FailureKneeKnowledgeLimb structureModelingMorbidity - disease rateNon-Insulin-Dependent Diabetes MellitusOperative Surgical ProceduresPathologyPatientsPerformanceProcessPropertyProteinsRattusResearchRodentSeedsSheepSiteSourceSpeedSprague-Dawley RatsStromal CellsSystemic diseaseTechnologyTestingVascular GraftVein graftage effectagedbiodegradable scaffoldcell motilityclinical translationcomorbiditycontrolled releasecostcytokinedesigndiabeticeffectiveness evaluationelastomericendothelial stem cellgraft failuregraft functionimprovedinfection riskinsightnon-diabeticpatient populationpre-clinicalreconstructionscaffoldstem cell populationwound healing
项目摘要
Elastic, Degradable Vascular Grafts with Helical Microfibers
When an artery occludes, rerouting blood flow with a vascular graft can save lives or limbs.
Autologous grafts are the preferred conduit for replacing small-diameter vessels. However, not all
patients have suitable donor vessels, and the wound healing complications associated with the
harvest can be severe. Synthetic grafts can be used but the foreign material does not degrade or
integrate with the host, leading to graft failure and risk of infection. These grafts function best in
large caliber arterial reconstruction but perform poorly in smaller arteries such as in the coronary
and below the knee arteries. We will overcome this challenge by using a degradable graft made of
elastomeric microfibers arranged in helices mimicking extracellular matrix fibers in the artery. Our
preliminary data in rats show these grafts remodel into compliant, elastic vascular conduits
resembling the native arteries. The proposed research will address two key questions for clinical
translation: 1) will host cells fully populate the long grafts needed for human applications and 2)
will the same transformation occur in aged patients and those with systemic diseases such as
diabetes? Correspondingly, Specific Aim 1 will investigate host remodeling of 7-inch-long
interposition grafts in a sheep carotid artery. Aim 2 will assess graft remodeling in Zucker Diabetic
Sprague-Dawley rats, a new polygenetic model of Type 2 diabetes. Aim 3 will evaluate the
effectiveness of controlled release of cytokines in the graft to overcome the limitations caused by
aging. Upon completion of this project, we expect to have a graft design ready for clinical
translation. The knowledge gained will have impact beyond vascular substitutes in the
development of other cardiovascular devices.
带有螺旋微纤维的弹性可降解血管移植物
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Edith Tzeng其他文献
Edith Tzeng的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Edith Tzeng', 18)}}的其他基金
Metformin BenefIts Lower Extremities with Intermittent Claudication (MOBILE_IC)
二甲双胍有益于间歇性跛行的下肢 (MOBILE_IC)
- 批准号:
10426266 - 财政年份:2022
- 资助金额:
$ 68.33万 - 项目类别:
Metformin BenefIts Lower Extremities with Intermittent Claudication (MOBILE_IC)
二甲双胍有益于间歇性跛行的下肢 (MOBILE_IC)
- 批准号:
10257312 - 财政年份:2022
- 资助金额:
$ 68.33万 - 项目类别:
Elastic, Degradable Vascular Grafts with Helical Microfibers
具有螺旋微纤维的弹性、可降解血管移植物
- 批准号:
10887286 - 财政年份:2021
- 资助金额:
$ 68.33万 - 项目类别:
Elastic, Degradable Vascular Grafts with Helical Microfibers
具有螺旋微纤维的弹性、可降解血管移植物
- 批准号:
10280660 - 财政年份:2021
- 资助金额:
$ 68.33万 - 项目类别:
Elastic, Degradable Vascular Grafts with Helical Microfibers
具有螺旋微纤维的弹性、可降解血管移植物
- 批准号:
10685260 - 财政年份:2021
- 资助金额:
$ 68.33万 - 项目类别:
Research Supplements to Promote Diversity in Vascular Graft Research
促进血管移植研究多样性的研究补充
- 批准号:
10619171 - 财政年份:2021
- 资助金额:
$ 68.33万 - 项目类别:
Xanthine oxidoreductase in impaired diabetic wound healing.
黄嘌呤氧化还原酶在糖尿病伤口愈合受损中的作用。
- 批准号:
10477928 - 财政年份:2016
- 资助金额:
$ 68.33万 - 项目类别:
Xanthine oxidoreductase in impaired diabetic wound healing.
黄嘌呤氧化还原酶在糖尿病伤口愈合受损中的作用。
- 批准号:
9138069 - 财政年份:2016
- 资助金额:
$ 68.33万 - 项目类别:
Xanthine oxidoreductase in impaired diabetic wound healing.
黄嘌呤氧化还原酶在糖尿病伤口愈合受损中的作用。
- 批准号:
10038744 - 财政年份:2016
- 资助金额:
$ 68.33万 - 项目类别:
相似海外基金
Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
- 批准号:
495182 - 财政年份:2023
- 资助金额:
$ 68.33万 - 项目类别:
Parkinson's disease and aging affect neural activation during continuous gait alterations to the split-belt treadmill: An [18F] FDG PET Study.
帕金森病和衰老会影响分体带跑步机连续步态改变期间的神经激活:[18F] FDG PET 研究。
- 批准号:
400097 - 财政年份:2019
- 资助金额:
$ 68.33万 - 项目类别:
The elucidation of the mechanism by which intestinal epithelial cells affect impaired glucose tolerance during aging
阐明衰老过程中肠上皮细胞影响糖耐量受损的机制
- 批准号:
19K09017 - 财政年份:2019
- 资助金额:
$ 68.33万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Does aging of osteocytes adversely affect bone metabolism?
骨细胞老化会对骨代谢产生不利影响吗?
- 批准号:
18K09531 - 财政年份:2018
- 资助金额:
$ 68.33万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Links between affect, executive function, and prefrontal structure in aging: A longitudinal analysis
衰老过程中情感、执行功能和前额叶结构之间的联系:纵向分析
- 批准号:
9766994 - 财政年份:2018
- 资助金额:
$ 68.33万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9320090 - 财政年份:2017
- 资助金额:
$ 68.33万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
10166936 - 财政年份:2017
- 资助金额:
$ 68.33万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9761593 - 财政年份:2017
- 资助金额:
$ 68.33万 - 项目类别:
Experimental Model of Depression in Aging: Insomnia, Inflammation, and Affect Mechanisms
衰老过程中抑郁症的实验模型:失眠、炎症和影响机制
- 批准号:
9925164 - 财政年份:2016
- 资助金额:
$ 68.33万 - 项目类别:
Experimental Model of Depression in Aging: Insomnia, Inflammation, and Affect Mechanisms
衰老过程中抑郁症的实验模型:失眠、炎症和影响机制
- 批准号:
9345997 - 财政年份:2016
- 资助金额:
$ 68.33万 - 项目类别: