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Elastic, Degradable Vascular Grafts with Helical Microfibers

具有螺旋微纤维的弹性、可降解血管移植物

基本信息

批准号：
10463745
负责人：
Edith Tzeng
金额：
$ 68.33万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10463745
关键词：
Address Affect Aging Animal Model Architecture Arteries Arteriovenous fistula Atherosclerosis Autologous Autologous Transplantation Automobile Driving Biological Bioreactors Blood Vessels Blood flow Bypass Caliber Cardiovascular Diseases Cardiovascular system Carotid Arteries Cells Clinical Coronary Data Deposition Development Devices Diabetes Mellitus Elderly Extracellular Matrix Fiber Goals Gold Harvest Human Immune response Impairment Implant In Situ Inflammation Interleukin-10 Intervention Kidney Failure Knee Knowledge Limb structure Modeling Morbidity - disease rate Non-Insulin-Dependent Diabetes Mellitus Operative Surgical Procedures Pathology Patients Performance Process Property Proteins Rattus Research Rodent Seeds Sheep Site Source Speed Sprague-Dawley Rats Stromal Cells Systemic disease Technology Testing Vascular Graft Vein graft age effect aged biodegradable scaffold cell motility clinical translation comorbidity controlled release cost cytokine design diabetic effectiveness evaluation elastomeric endothelial stem cell graft failure graft function improved infection risk insight non-diabetic patient population pre-clinical reconstruction scaffold stem cell population wound healing

项目摘要

Elastic, Degradable Vascular Grafts with Helical Microfibers When an artery occludes, rerouting blood flow with a vascular graft can save lives or limbs. Autologous grafts are the preferred conduit for replacing small-diameter vessels. However, not all patients have suitable donor vessels, and the wound healing complications associated with the harvest can be severe. Synthetic grafts can be used but the foreign material does not degrade or integrate with the host, leading to graft failure and risk of infection. These grafts function best in large caliber arterial reconstruction but perform poorly in smaller arteries such as in the coronary and below the knee arteries. We will overcome this challenge by using a degradable graft made of elastomeric microfibers arranged in helices mimicking extracellular matrix fibers in the artery. Our preliminary data in rats show these grafts remodel into compliant, elastic vascular conduits resembling the native arteries. The proposed research will address two key questions for clinical translation: 1) will host cells fully populate the long grafts needed for human applications and 2) will the same transformation occur in aged patients and those with systemic diseases such as diabetes? Correspondingly, Specific Aim 1 will investigate host remodeling of 7-inch-long interposition grafts in a sheep carotid artery. Aim 2 will assess graft remodeling in Zucker Diabetic Sprague-Dawley rats, a new polygenetic model of Type 2 diabetes. Aim 3 will evaluate the effectiveness of controlled release of cytokines in the graft to overcome the limitations caused by aging. Upon completion of this project, we expect to have a graft design ready for clinical translation. The knowledge gained will have impact beyond vascular substitutes in the development of other cardiovascular devices.

带有螺旋微纤维的弹性可降解血管移植物