Longitudinal Analysis of Diffusion Tensor Imaging to Discover Adolescent Alcohol Use Effect

弥散张量成像的纵向分析以发现青少年饮酒的影响

• 批准号: 10466805
• 负责人: Qingyu Zhao
• 金额: $ 13.71万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-10 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10466805
• 关键词: Abstinence; Adolescence; Adolescent; Adult; Age; Alcohol abuse; Alcohol consumption; Alcohols; Behavioral; Biological Markers; Brain; Brain Diseases; Brain region; Cause of Death; Child Rearing; Clinical; Collection; Complex; Data; Dependence; Development; Diagnosis; Diffuse; Diffusion Magnetic Resonance Imaging; Distal; Ethnic Origin; Functional Magnetic Resonance Imaging; Future; Gender; Heavy Drinking; Heterogeneity; Image; Impaired cognition; Injury; Link; Longitudinal prospective study; Measurement; Modeling; Neurons; Neuropsychology; Participant; Persons; Phenotype; Prevention; Preventive care; Recording of previous events; Research Personnel; Scanning; Structure; Teenagers; Testing; Training; United States; Variant; Visit; Youth; adolescent brain development; alcohol effect; alcohol exposure; alcohol use disorder; alcohol use initiation; alcohol-related injury; base; cohort; deviant; drinking; drinking onset; early drinking; experience; improved; insight; longitudinal analysis; multimodal neuroimaging; neurodevelopment; repaired; resilience; sex; tool; underage drinking; white matter

Longitudinal Analysis of Diffusion Tensor Imaging to Discover Adolescent Alcohol Use Effect PROJECT ABSTRACT Alcohol abuse is the third leading preventable cause of death in the United States. A signature injury of Alcohol Use Disorder (AUD) is in the white-matter (WM) microstructure and its constituents, which enable connectivity of proximal and distal brain structures and functional integration. Despite the progress in understanding alcohol’s effects in adults, still unclear is the causal direction between abnormal WM maturation and initiation of heavy yet non-dependent drinking during adolescence. To gain insight into regional development of connectivity, the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA), a prospective longitudinal study of 831 youth to track normal and alcohol-related deviant neurodevelopmental trajectories, acquired diffusion tensor imaging (DTI) data annually. Unraveling alcohol effects from the complex dynamic course of adolescent neurodevelopment requires highly sensitive analysis approaches. In this project, I propose a new type of longitudinal DTI analysis, in which a unified trajectory model is used both for explicitly capturing biologically-plausible variation in DTI measurements across visits within each subject and for estimating a group-level developmental trajectory. Such an approach will result in longitudinally consistent DTI measurements enabling accurate characterization of microstructural development in normal adolescents. Based on this approach, I will test the hypothesis that precursors of drinking onset and the disruption effects induced by initiation of alcohol use are related to different brain regions. The analysis will identify the precursors by comparing developmental trajectories prior to drinking onset between the no-to-low and heavy drinking cohorts and will identify the disruption by comparing trajectories after drinking onset. The alcohol- induced disruption to WM maturation will be further stratified with respect to age, highlighting the heightened vulnerability in younger adolescents. Lastly, the proposed longitudinal analysis also facilitates further tracking of microstructural remodeling following abstinence to identify reversible or persistent alcohol-related injury. Revealed imaging phenotypes linked to adolescent heavy drinking could point to potential causes and precursors of AUD, which could in turn improve diagnosis and prevention in clinical settings. Moreover, researchers will be able to use the proposed longitudinal approach as a general tool to answer their neuroscientific questions in the context of seeking developmental change.

扩散张量成像的纵向分析以发现青春期酒精的效果 项目摘要 酗酒是美国第三大可预防的死亡原因。酒精的标志性伤害 使用障碍（AUD）在白色 - 摩尔（WM）微观结构及其构成中，这使连通性 近端和远端大脑结构以及功能整合。尽管理解取得了进展 酒精对成人的影响，仍然不清楚WM成熟异常的因果方向 青少年期间大量但非依赖的饮酒。洞悉区域发展 连通性，Ademente（Ncanda）的国家酒精和神经发育联盟， 对831名青年的前瞻性纵向研究跟踪正常和酒精有关的变形神经发育 轨迹，每年获得的扩散张量成像（DTI）数据。从综合体中解散酒精的影响 青少年神经发育的动态过程需要高度敏感的分析方法。在这个项目中， 我提出了一种新型的纵向DTI分析，其中使用统一的轨迹模型进行明确 捕获每个受试者内部访问的DTI测量中的生物学上可见变化，用于 估计群体级的发展轨迹。这种方法将导致纵向一致的DTI 测量值能够准确地表征正常青少年的微观结构发展。 基于这种方法，我将检验以下假设，即饮酒的前体和破坏效果 通过饮酒引起的诱导与不同的大脑区域有关。分析将确定 前体通过在饮酒开始之前比较发育轨迹 饮酒队列，将通过比较饮酒后通过比较轨迹来确定破坏。酒精 - 诱发WM成熟的破坏将进一步分层 年轻青少年的脆弱性。最后，提出的纵向分析也有助于进一步跟踪 节制后的微结构重塑以识别可逆性或持续性酒精相关的损伤。 与青少年大量饮酒有关的揭示成像表型可能指出了潜在的原因和 AUD的前体，这反过来又可以改善临床环境中的诊断和预防。而且， 研究人员将能够使用拟议的纵向方法作为一般工具来回答他们的 在寻求发展变化的背景下的神经科学问题。