Immune Tolerance Network

项目摘要/摘要 ITN的使命是通过进行免疫耐受的临床应用来促进免疫耐受的临床应用 基于可测试的机械假说的新兴疗法的高质量临床试验。 ITN的结构是为了询问不同的免疫学疾病 光谱，整合了创新的临床研究和尖端的免疫学实验室 分析。ITN方法--新耐受疗法的临床评估，而我们 同时评估疾病的细胞、遗传和免疫学机制以及如何 它们对治疗的反应是改变的--创建了一个促进跨疾病和 跨学科知识，所有这些都旨在加速重大疾病的治疗选择。 在此续订申请中，我们描述了将实现以下目标的科学和操作框架 ITN成功地促进了移植耐受疗法的发展， 自身免疫力和过敏。我们概述了将我们当前的战略演变为下一步战略的过程 一代计划中的试验，以及我们计划如何运营一个灵活的、面向未来的 组织，准备领导和采用目前未知的创新。我们提出了一个 涉及数百名研究人员、顾问和临床站点的协作结构 与ITN工作人员的核心团队合作，运营一个既科学又 财务效率高。ITN最近采用的几项新创新将鼓励 学术研究人员的广泛参与，包括扩大资源共享和 数据共享操作。来自Benaroya Research的牵头机构承诺 研究所和加州大学旧金山分校，以及其他20多家机构的参与 作为具有领导和主要咨询作用的主要机构，ITN努力继续 成功开创高影响力临床试验和机制研究领域的先河 医疗需要。

Project summary / ABSTRACT The mission of the ITN is to advance the clinical application of immune tolerance by performing high quality clinical trials of emerging therapeutics based upon testable mechanistic hypotheses. The ITN is structured in order to interrogate different diseases across the immunologic spectrum, with integration of innovative clinical studies and cutting edge immunology laboratory analysis. The ITN approach—clinical assessment of novel tolerance therapeutics, while we simultaneously evaluate the cellular, genetic, and immunologic mechanisms of disease and how they are altered in response to therapy—creates a framework for advancing cross-disease and cross-discipline knowledge, all designed to accelerate therapeutic options for major diseases. In this renewal application, we describe the scientific and operational framework that will enable the ITN to successfully enhance the development of tolerance therapies in transplantation, autoimmunity, and allergy. We outline a process to evolve our current strategies into the next generation of planned trials, as well as how we plan to operate a nimble, future-focused organization, poised to lead and adopt innovations that are currently unknown. We propose a collaborative structure involving hundreds of investigators, advisors, and clinical sites working in tandem with a core group of ITN staff, operating a program that is both scientifically and financially efficient. Several new innovations recently adopted by the ITN will encourage widespread involvement from academic investigators, including expanded resource sharing and data sharing operations. With lead institutional commitment from the Benaroya Research Institute and the University of California San Francisco, and participation of more than 20 other major institutions represented in leadership and major advisory roles, the ITN strives to continue to successfully pioneer high impact clinical trials and mechanistic studies in areas of unmet medical need.