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3D Bioprinted Omentum tissue to model ovarian cancer metastasis

3D Bioprinted Omentum tissue to model ovarian cancer metastasis
3D 生物打印网膜组织用于模拟卵巢癌转移
批准号：
10469252
负责人：
Marc Ferrer-Alegre
金额：
$73.78万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10469252
关键词：
3-DimensionalAnimal ModelAntineoplastic AgentsBiological AssayBlood VesselsCancer Cell GrowthCell LineCell modelCell-Matrix JunctionCellsDevelopmentEndothelial CellsFibroblastsFluorescence MicroscopyFunctional disorderGenetically Engineered MouseGoalsGrowthHumanImmunodeficient MouseIn VitroLabelLocationMalignant NeoplasmsMalignant neoplasm of ovaryMesothelial CellMetastatic Malignant Neoplasm to the OvaryModelingMonitorMorphologyNeoplasm MetastasisOmentumPatientsPericytesPhysiologicalPhysiologyPreclinical TestingProductionProtocols documentationSiteSurfaceSuspensionsThree-Dimensional ImagingTissuesToxicity TestsXenograft procedurebiofabricationbioprintingcancer cellcell growthcellular imagingclinical efficacydrug developmentdrug discoveryefficacy testingmonolayerneoplastic cellnovel therapeuticsovarian neoplasmpredictive testpreventscreeningtumor

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英文摘要
We have developed biofabrication protocols for the production of a vascularized omentum model that includes patient derived fibroblasts, endothelial cells and pericytes, and a layer of patient mesothelial cells. Patient cells were obtained from our collaborators Dr. Ernst Lengyel and Hilary Kenny. Addition of a suspension of fluorescently labeled ovarian tumor cells to the top of mesothelial cell layer on the tissue and used fluorescence microscopy to monitor tumor formation inside the tissue. 3D imaging analysis have been developed to quantiate size and number of tumors, and their location. These analytics will be used to screen a focused set of compounds for compounds that prevent tumor formation in the tissue.
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