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Identification of small molecule inhibitors of miR-155 expression in Th17 cells

Identification of small molecule inhibitors of miR-155 expression in Th17 cells
Th17细胞中miR-155表达的小分子抑制剂的鉴定
批准号：
10005785
负责人：
Marc Ferrer-Alegre
金额：
$13.27万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10005785
关键词：
Autoimmune DiseasesBiological AssayBiologyCellsChemicalsCollaborationsCrohn&aposs diseaseDiseaseExperimental Autoimmune EncephalomyelitisExtramural ActivitiesGenomicsGoalsInformaticsModelingMultiple SclerosisPharmaceutical ChemistryPhenotypeProcessProductionPsoriasisResearchResearch PersonnelSynthesis ChemistryTestingUnited States National Institutes of HealthValidationWorkassay developmentbasedrug developmentdrug discoveryinhibitor/antagonistlead optimizationmouse modelnew technologynovelscreeningsmall moleculesmall molecule inhibitorsmall molecule therapeuticstherapeutic developmenttool

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During this period, the project team worked to validate and characterize hit compounds identified in the previously completed primary miR-155 screen. Compounds were confirmed for their ability to down-regulate Il-17 production in functional assays using primary cells. Select hit molecules have been advanced toward testing in EAE, a mouse model for multiple sclerosis. Following additional characterization and validation, molecules with promising activity profiles may hold promise for the treatment of autoimmune diseases like multiple sclerosis, Crohn's disease and psoriasis.
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