NIDCD 临床研究和护理核心-猫眼课题宝

NIDCD 临床研究和护理核心

批准号：

10470081

负责人：

CARTER VAN WAES

金额：

$254.1万

依托单位：

NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/10470081

关键词：

AQP1 gene Adjuvant Study Administrator Admission activity Adult Affect Ambulatory Care Facilities Appointment Area Audiology Care given by nurses Caring Child Chromosome Mapping Cisplatin Clinical Clinical Clerkship Clinical Data Clinical Investigator Clinical Research Clinical Services Clinical Trials Clinics and Hospitals Communication Communication impairment Complex Consult Consultations Continuing Education Credentialing Data Data Collection Databases Development Disease Dose Drug Kinetics Emergency Situation Endoscopy Equilibrium Equipment and Supplies Evaluation Fellowship Fostering Genes Genetic study Genomics Head Cancer Head and Neck Cancer Head and Neck Disorder Head and Neck Squamous Cell Carcinoma Head and Neck Surgeon Hearing Hearing problem Hereditary Disease Hospital Administration Hospitals Hour Human Human Papilloma Virus Vaccine Human Papillomavirus Human Resources Human papilloma virus infection Image Immune India Inpatients Institutes Institutional Review Boards Intervention Studies Intramural Research Program Laboratories Labyrinth Maintenance Malignant Neoplasms Medical Medical Students Mentors Mission Molecular Molecular Analysis Monitor NF-kappa B National Institute on Deafness and Other Communication Disorders Natural History Neck Cancer Nurse Practitioners Nursing Research Olfactory Neuroblastoma Operative Surgical Procedures Otolaryngologist Otolaryngology Outpatients Pakistan Parotid Gland Pathogenesis Patient Care Patient Education Patients Phase Phase I/II Trial Phenotype Physicians Program Development Proteomics Protocols documentation Provider Records Recurrence Recurrent respiratory papillomatosis Research Research Support Research Training Resectable Resources Safety Salivary Scientist Services Signal Transduction Solid Neoplasm Specimen Speech Supervision Surgeon Syndrome Testing Time Training Transforming Growth Factor beta Travel Triad Acrylic Resin United States National Institutes of Health Vaccines Vestibular Aqueduct Visit Voice Work adeno-associated viral vector anti-PD-L1 anti-tumor immune response atorvastatin career development chemotherapy cisplatin induced hearing loss clinical care clinical implementation data management genetic analysis genetic deafness genome editing hearing impairment hearing restoration hereditary hearing loss human subject inpatient service irradiation meetings neoplasm therapy outpatient programs patient screening phase 1 study phase 2 study programs protocol development quality assurance recruit response symposium transcription factor volunteer

中文摘要

翻译

NIDCD临床研究和护理核心支持以下NIDCD项目： 1 Z01-DC-000016核因子-kappaB在影响人类沟通的肿瘤分子发病机制和治疗中的作用 1 Zia DC000039综合征性和非综合征性耳聋基因鉴定 1 Zia DC000046人类沟通障碍的遗传学研究 1人遗传性耳聋的Zia DC000060分子分析 1 Zia DC000064听力和平衡障碍临床分析 1头颈癌中ZIA-DC-000073信号和转录因子网络的相互作用 1头颈癌ZIA-DC-000074基因组学和蛋白质组学研究 1个ZIA-DC-000082神经病学项目 1-ZIA-DC-000087的特性及其增强头颈癌抗肿瘤免疫应答的研究 1-ZIA-DC-000088成人内耳听力恢复的细胞和分子机制 1-ZIA-DC-000090机制及顺铂治疗头颈癌的优化组合核心支持的NIDCD和协作协议包括： OH93-DC-0016-非综合征遗传性耳聋基因图谱：印度/巴基斯坦方案 97-DC-0180-遗传性耳聋的遗传分析 01-DC-0228-前庭导水管扩大所致听力障碍的临床和分子分析 01-DC-0229-遗传性听力和平衡障碍的遗传分析 17-DC-0138-顺铂和他汀类药物耳毒性 18-DC-0051-NIDCD生物检疫协议 20-DC-0047遗传性耳聋的自然病史和基因组编辑 21-DC-0002阿托伐他汀降低顺铂所致听力损失的III期干预研究 21-C-0009儿童和成人嗅神经母细胞瘤的自然史研究 000077例头颈部疾病的临床资料和标本 000141听力不稳定表型 15-D-0129剂量递增研究评价单次注射携带人水通道蛋白-1基因的腺相关病毒载体治疗放射性腮腺功能减退的安全性 19-C-0041双适形调强再放疗治疗局部复发的头颈部鳞状细胞癌 19-C-0002复发性呼吸道乳头状瘤病患者M7824的II期研究 20-C-0024抗PD-L1/转化生长因子-β陷阱(M7824)单独及联合三联疫苗和N-803治疗与人乳头瘤病毒感染无关的可切除头颈部鳞状细胞癌 20-C-0155期试验研究SX-682联合M7824和CV301治疗晚期实体瘤的安全性、耐受性、药代动力学、免疫学和临床活性 HPV疫苗PRGN-2009单独或联合抗PD-L1/TGF-β陷阱(M7824)治疗HPV阳性癌症患者的I/II期20-C-0104试验 21-C-0013佐剂PRGN-2012治疗成人复发性呼吸道乳头状瘤病的I期研究 NIDCD临床研究和护理核心每年支持3000多个门诊评估。耳鼻咽喉科核心医生每年要做50-100例大手术。在高级临床助理期间，工作人员指导医学生。耳鼻喉科外科科学家职业发展计划是通过强迫症协调的。

英文摘要

The NIDCD Core for Clinical Research and Care supports the following NIDCD projects: 1 Z01-DC-000016 NF-kappaB in the molecular pathogenesis and therapy of Neoplasms Affecting Human Communication 1 ZIA DC000039 Identification of Genes Causing Syndromic And Nonsyndromic Hearing Impairment 1 ZIA DC000046 Genetic Studies of Human Communications Disorders 1 ZIA DC000060 Molecular Analysis Of Human Hereditary Deafness 1 ZIA DC000064 Clinical Analysis Of Disorders Of Hearing And Balance 1 ZIA-DC-000073 Signal and Transcription Factor Network Interactions in Head and Neck Cancer 1 ZIA-DC-000074 Genomics and Proteomics of Head and Neck Cancer 1 ZIA-DC-000082 Neurotology Program 1 ZIA-DC-000087 Characterization & Enhancement of Anti-tumor Immune Responses in Head & Neck Cancer 1-ZIA-DC-000088 Cellular and Molecular Pathogenesis of Hearing Restoration in Adullt Inner Ear 1-ZIA-DC-000090 Mechanisms and Optimal Combination of Cisplatin Chemotherapy for Head and Neck Cancer The NIDCD and collaborative protocols supported by the core include: OH93-DC-0016 - Nonsyndromic Hereditary Hearing Impairment Gene Mapping: India / Pakistan Protocol 97-DC-0180 - Genetic Analysis of Human Hereditary Hearing Impairment 01-DC-0228 - Clinical and Molecular Analysis of Hearing Impairment with Enlarged Vestibular Aqueducts 01-DC-0229- Genetic Analysis of Hereditary Disorders of Hearing and Balance 17-DC-0138 - Cisplatin and statins in ototoxcity 18-DC-0051 - NIDCD Biospecimens protocol 20-DC-0047 Natural History and Genome Editing in Dominant Hearing Loss 21-DC-0002 Phase III Interventional Study using Atorvastatin to Reduce Cisplatin-Induced Hearing Loss 21-C-0009 A Natural History Study of Children and Adults With Olfactory Neuroblastoma 000077 Clinical Data and Specimens in head and neck disorders 000141 Hearing Instability Phenotyping 15-D-0129 Dose-Escalation Study Evaluating the Safety of a Single Administration of an Adeno-Associated Virus Vector Encoding Human Aquaporin-1 in Irradiation-Induced Parotid Salivary Hypofunction 19-C-0041 Birinapant and Intensity Modulated Re-Irradiation Therapy (IMRRT) for Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma 19-C-0002 A Phase II Study of M7824 in Subjects with Recurrent Respiratory Papillomatosis 20-C-0024 Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination with TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated with Human Papillomavirus Infection 20-C-0155 Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetic , Immune and Clinical Activity of SX-682 in Combination with M7824 With CV301 TRICOM in Advanced Solid Tumors 20-C-0104 Phase I/II Trial of HPV Vaccine PRGN-2009 Alone or in Combination with Anti-PD-L1/TGF-Beta Trap (M7824) in Subjects with HPV Positive Cancers 21-C-0013 A Phase I Study of Adjuvant PRGN-2012 in Adult Patients with Recurrent Respiratory Papillomatosis The NIDCD Core for Clinical Research and Care supports over 3,000 outpatient clinic evaluations per year. Core otolaryngologists perform 50-100 major surgical cases annually. Staff mentor medical students during senior clinical clerkships. The Otolaryngologist Surgeon Scientist Career Development Program is coordinated through the OCD.

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