NF-kappaB in pathogenesis and therapy of head and neck cancer
NF-κB 在头颈癌发病机制和治疗中的作用
基本信息
- 批准号:10688908
- 负责人:
- 金额:$ 35.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AlcoholsBiological MarkersCessation of lifeClinicalCytologyCytotoxic agentDefectDeglutitionDiagnosisDiseaseDrug TargetingEarly DiagnosisEarly treatmentFRAP1 geneGene ExpressionGeneticHead and Neck CancerHead and Neck Squamous Cell CarcinomaHuman PapillomavirusImpairmentInvestigationLarynxMalignant NeoplasmsMediator of activation proteinMolecularMulticenter TrialsNF-kappa BNormal tissue morphologyOperative Surgical ProceduresOral cavityPathogenesisPathway interactionsPatientsPharyngeal structurePlayPreventionPrevention approachProgressive DiseaseQuality of lifeRNA interference screenRadiationRecurrenceRecurrent diseaseReporterRoleSignal PathwaySignal TransductionSpeechSquamous EpitheliumTNF geneThe Cancer Genome AtlasTherapeuticVoicechemotherapygenome-wideirradiationmalignant phenotypenotch proteinnovel strategiesresponseside effecttargeted treatmenttherapy resistanttobacco exposuretranscription factor
项目摘要
As part of The Cancer Genome Atlas group characterizing head and neck cancer, we have identified components of the classical and alternative NF-kB, PI3K-mTOR, and Notch pathways as candidate genetic drivers for aberrant NF-kB activation and defects in death signaling.
A multi-center trial targeting IAPs in the classical TNF-NF-kB pathway in combination with re-irradiation continues.
Studies using a genome wide RNAi screen employing NF-kB reporter lines have identified potential drug targets promoting NF-kB activation, under investigation.
作为表征头颈癌的癌症基因组图谱组的一部分,我们已经确定了经典和替代NF-kB,PI 3 K-mTOR和Notch途径的组分作为异常NF-kB激活和死亡信号缺陷的候选遗传驱动因素。
靶向经典TNF-NF-kB途径中的IAP与再照射组合的多中心试验仍在继续。
使用基因组范围的RNAi筛选,采用NF-κ B报告细胞系的研究已经确定了促进NF-κ B激活的潜在药物靶点,正在研究中。
项目成果
期刊论文数量(29)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Immunohistochemical analysis of NF-κB in human tumor tissue.
人类肿瘤组织中 NF-κB 的免疫组织化学分析。
- DOI:10.1007/978-1-4939-2422-6_28
- 发表时间:2015
- 期刊:
- 影响因子:0
- 作者:Allen,ClintT;VanWaes,Carter
- 通讯作者:VanWaes,Carter
Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer.
- DOI:10.1038/onc.2013.49
- 发表时间:2014-02-27
- 期刊:
- 影响因子:8
- 作者:
- 通讯作者:
CCR 20th anniversary commentary: Preclinical study of proteasome inhibitor bortezomib in head and neck cancer.
- DOI:10.1158/1078-0432.ccr-14-2550
- 发表时间:2015-03-01
- 期刊:
- 影响因子:0
- 作者:Allen CT;Conley B;Sunwoo JB;Van Waes C
- 通讯作者:Van Waes C
Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers.
- DOI:10.1158/0008-5472.can-17-0642
- 发表时间:2018-08-15
- 期刊:
- 影响因子:11.2
- 作者:Zhang J;Chen T;Yang X;Cheng H;Späth SS;Clavijo PE;Chen J;Silvin C;Issaeva N;Su X;Yarbrough WG;Annunziata CM;Chen Z;Van Waes C
- 通讯作者:Van Waes C
Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer.
- DOI:10.1158/1078-0432.ccr-09-1352
- 发表时间:2009-10-01
- 期刊:
- 影响因子:0
- 作者:Arun P;Brown MS;Ehsanian R;Chen Z;Van Waes C
- 通讯作者:Van Waes C
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CARTER VAN WAES其他文献
CARTER VAN WAES的其他文献
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{{ truncateString('CARTER VAN WAES', 18)}}的其他基金
GENE AND IMMUNOTHERAPY OF NEOPLASMS AFFECTING HUMAN COMMUNICATION
影响人类交流的肿瘤基因和免疫治疗
- 批准号:
6289632 - 财政年份:
- 资助金额:
$ 35.93万 - 项目类别:
NF-kappaB in pathogenesis and therapy of head and neck cancer
NF-κB 在头颈癌发病机制和治疗中的作用
- 批准号:
8349616 - 财政年份:
- 资助金额:
$ 35.93万 - 项目类别:
Molecular Therapy Of Neoplasms Affecting Human Communica
影响人类通讯的肿瘤的分子治疗
- 批准号:
6966643 - 财政年份:
- 资助金额:
$ 35.93万 - 项目类别:
NF-kappaB in pathogenesis and therapy of head and neck cancer
NF-κB 在头颈癌发病机制和治疗中的作用
- 批准号:
8745647 - 财政年份:
- 资助金额:
$ 35.93万 - 项目类别:
NF-kappaB in pathogenesis and therapy of head and neck cancer
NF-κB 在头颈癌发病机制和治疗中的作用
- 批准号:
9147422 - 财政年份:
- 资助金额:
$ 35.93万 - 项目类别:
Gene And Immunotherapy Of Neoplasms Affecting Human Comm
影响人类通讯的肿瘤的基因和免疫治疗
- 批准号:
6690276 - 财政年份:
- 资助金额:
$ 35.93万 - 项目类别:
Molecular Therapy Of Neoplasms Affecting Human Communication
影响人类交流的肿瘤的分子治疗
- 批准号:
7593327 - 财政年份:
- 资助金额:
$ 35.93万 - 项目类别:
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