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NF-kappaB in pathogenesis and therapy of head and neck cancer

NF-kappaB in pathogenesis and therapy of head and neck cancer
NF-κB 在头颈癌发病机制和治疗中的作用
批准号：
10688908
负责人：
CARTER VAN WAES
金额：
$35.93万
依托单位：
NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10688908
关键词：
AlcoholsBiological MarkersCessation of lifeClinicalCytologyCytotoxic agentDefectDeglutitionDiagnosisDiseaseDrug TargetingEarly DiagnosisEarly treatmentFRAP1 geneGene ExpressionGeneticHead and Neck CancerHead and Neck Squamous Cell CarcinomaHuman PapillomavirusImpairmentInvestigationLarynxMalignant NeoplasmsMediator of activation proteinMolecularMulticenter TrialsNF-kappa BNormal tissue morphologyOperative Surgical ProceduresOral cavityPathogenesisPathway interactionsPatientsPharyngeal structurePlayPreventionPrevention approachProgressive DiseaseQuality of lifeRNA interference screenRadiationRecurrenceRecurrent diseaseReporterRoleSignal PathwaySignal TransductionSpeechSquamous EpitheliumTNF geneThe Cancer Genome AtlasTherapeuticVoicechemotherapygenome-wideirradiationmalignant phenotypenotch proteinnovel strategiesresponseside effecttargeted treatmenttherapy resistanttobacco exposuretranscription factor

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中文摘要
翻译
作为表征头颈部癌症的癌症基因组图谱组的一部分，我们已经确定了经典和替代NF-kB、PI3K-mTOR和Notch通路的组成部分，作为NF-kB异常激活和死亡信号缺陷的候选遗传驱动因素。
英文摘要
As part of The Cancer Genome Atlas group characterizing head and neck cancer, we have identified components of the classical and alternative NF-kB, PI3K-mTOR, and Notch pathways as candidate genetic drivers for aberrant NF-kB activation and defects in death signaling. A multi-center trial targeting IAPs in the classical TNF-NF-kB pathway in combination with re-irradiation continues. Studies using a genome wide RNAi screen employing NF-kB reporter lines have identified potential drug targets promoting NF-kB activation, under investigation.
期刊论文(29)
专著(0)
科研奖励(0)
会议论文
Immunohistochemical analysis of NF-κB in human tumor tissue.
人类肿瘤组织中 NF-κB 的免疫组织化学分析。
DOI： 10.1007/978-1-4939-2422-6_28
发表时间： 2015
期刊： Methods in molecular biology (Clifton, N.J.)
影响因子： --
作者： [Allen,ClintT, VanWaes,Carter]
通讯作者： VanWaes,Carter
Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer.
DOI： 10.1038/onc.2013.49
发表时间： 2014-02-27
期刊： Oncogene
影响因子： 8
作者： []
通讯作者：
CCR 20th anniversary commentary: Preclinical study of proteasome inhibitor bortezomib in head and neck cancer.
DOI： 10.1158/1078-0432.ccr-14-2550
发表时间： 2015-03-01
期刊： Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子： --
作者： [Allen CT, Conley B, Sunwoo JB, Van Waes C]
通讯作者： Van Waes C
Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers.
DOI： 10.1158/0008-5472.can-17-0642
发表时间： 2018-08-15
期刊： Cancer research
影响因子： 11.2
作者： [Zhang J, Chen T, Yang X, Cheng H, Späth SS, Clavijo PE, Chen J, Silvin C, Issaeva N, Su X, Yarbrough WG, Annunziata CM, Chen Z, Van Waes C]
通讯作者： Van Waes C
共 22 条
    GENE AND IMMUNOTHERAPY OF NEOPLASMS AFFECTING HUMAN COMMUNICATION
    Molecular Therapy Of Neoplasms Affecting Human Communica
    NIDCD Core for Clinical Research and Care
    NF-kappaB in pathogenesis and therapy of head and neck cancer
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