NIDCD Core for Clinical Research and Care

NIDCD 临床研究和护理核心

• 批准号: 10249876
• 负责人: CARTER VAN WAES
• 金额: $ 222.91万
• 依托单位: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10249876
• 关键词: Administrator; Admission activity; Affect; Ambulatory Care Facilities; Appointment; Area; Audiology; Care given by nurses; Caring; Chromosome Mapping; Cisplatin; Clinical; Clinical Clerkship; Clinical Investigator; Clinical Research; Clinical Research Protocols; Clinical Services; Clinical Trials; Clinics and Hospitals; Communication; Communication impairment; Complex; Consult; Continuing Education; Credentialing; Cryptococcus; Data; Data Collection; Databases; Development; Disease; Emergency Situation; Endoscopy; Equilibrium; Equipment and Supplies; Evaluation; Fellowship; Fostering; Genes; Genetic study; Genomics; Head Cancer; Head and Neck Cancer; Head and Neck Surgeon; Head and Neck Surgery; Hearing problem; Hereditary Disease; Hospital Administration; Hospitals; Hour; Human; Human Resources; India; Inpatients; Institutes; Institutional Review Boards; Intramural Research Program; Laboratories; Labyrinth; Maintenance; Medical; Medical Students; Meningoencephalitis; Mentors; Mission; Molecular; Molecular Analysis; Monitor; NF-kappa B; National Institute on Deafness and Other Communication Disorders; Neck Cancer; Nursing Research; Operative Surgical Procedures; Otolaryngologist; Otolaryngology; Outpatients; Pakistan; Pathogenesis; Patient Care; Patient Education; Patients; Physicians; Policies; Program Development; Proteomics; Protocols documentation; Provider; Records; Reporting; Research; Research Support; Research Training; Resources; Scientist; Services; Signal Transduction; Speech; Supervision; Surgeon; Syndrome; Testing; Time; Training; Travel; United States National Institutes of Health; Vestibular Aqueduct; Visit; Voice; anti-tumor immune response; career development; chemotherapy; clinical care; clinical implementation; data management; effective therapy; genetic analysis; genetic deafness; hearing impairment; hearing restoration; hereditary hearing loss; human subject; inpatient service; meetings; multidisciplinary; neoplasm therapy; outpatient programs; patient screening; precision medicine; programs; protocol development; quality assurance; recruit; response; symposium; transcription factor; volunteer

The NIDCD Core for Clinical Research and Care supports the following NIDCD projects: 1 Z01-DC-000016 NF-kappaB in the molecular pathogenesis and therapy of Neoplasms Affecting Human Communication 1 ZIA DC000039 Identification of Genes Causing Syndromic And Nonsyndromic Hearing Impairment 1 ZIA DC000046 Genetic Studies of Human Communications Disorders 1 ZIA DC000060 Molecular Analysis Of Human Hereditary Deafness 1 ZIA DC000064 Clinical Analysis Of Disorders Of Hearing And Balance 1 ZIA-DC-000073 Signal and Transcription Factor Network Interactions in Head and Neck Cancer 1 ZIA-DC-000074 Genomics and Proteomics of Head and Neck Cancer 1 ZIA-DC-000082 Neurotology Program 1 ZIA-DC-000087 Characterization & Enhancement of Anti-tumor Immune Responses in Head & Neck Cancer 1-ZIA-DC-000088 Cellular and Molecular Pathogenesis of Hearing Restoration in Adullt Inner Ear 1-ZIA-DC-000090 Mechanisms and Optimal Combination of Cisplatin Chemotherapy for Head and Neck Cancer The NIDCD protocols supported by the core include: Oh93-DC-0016 - Nonsyndromic Hereditary Hearing Impairment Gene Mapping: India / Pakistan Protocol 97-DC-0180 - Genetic Analysis of Human Hereditary Hearing Impairment 01-DC-0099 - Evaluation for NIDCD Head and Neck Surgery Branch Clinical Research Protocols 01-DC-0228 - Clinical and Molecular Analysis of Hearing Impairment Associated with Enlarged Vestibular Aqueducts (EVA) 01-DC-0229- Genetic Analysis of Hereditary Disorders of Hearing and Balance 17-DC-0138 - Cisplatin and statins in ototoxcity 18-DC-0051 - NIDCD Biospecimens protocol The NIDCD Core for Clinical Research and Care supports over 3,000 outpatient clinic evaluations per year. Core otolaryngologists perform 50-100 major surgical cases annually. Staff mentor medical students during senior clinical clerkships. The Otolaryngolist Surgeon Scientist Career Development Program coordinated through the OCD, recruited two candidates in the past year. Selected Collaborative Reports: Gochuico BR, Ziegler SG, Ten NS, Balanda NJ, Mason CE, Zumbo P, Evans CA, Van Waes C, Gahl WA, Malicdan MCV.A comprehensive, multidisciplinary, precision medicine approach to discover effective therapy for an undiagnosed, progressive, fibroinflammatory disease Transl Res. 2020 Jan;215:31-40. doi: 10.1016/j.trsl.2019.08.008. Epub 2019 Aug 28. King KA, Ansari G, Panackal AA, Zalewski C, Anjum S, Bennett JE, Beri A, Kim HJ, Hammoud D, Brewer CC, Williamson PR. Audiologic and Otologic Complications of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Patients. Otol Neurotol. 2019 Jul;40(6):e657-e664. doi: 10.1097/MAO.0000000000002242.

NIDCD临床研究和护理核心支持以下NIDCD项目： 1 Z 01-DC-000016 NF-kappaB在影响人类交流的神经系统疾病的分子发病机制和治疗中的作用 1 ZIA DC 000039综合征型和非综合征型听力障碍基因的鉴定 1 ZIA DC 000046人类交流障碍的遗传学研究 1 ZIA DC 000060人类遗传性耳聋分子分析 1 ZIA DC 000064听力和平衡障碍的临床分析 1 ZIA-DC-000073头颈癌中的信号和转录因子网络相互作用 1 ZIA-DC-000074头颈癌基因组学和蛋白质组学 1 ZIA-DC-000082神经耳科项目 1 ZIA-DC-000087头颈癌中抗肿瘤免疫应答的表征和增强 1-ZIA-DC-000088成人内耳听力恢复的细胞和分子发病机制 1-ZIA-DC-000090顺铂化疗治疗头颈癌的机制及最佳组合 核心支持的NIDCD协议包括： Oh 93-DC-0016 -非综合征型遗传性听力障碍基因定位：印度/巴基斯坦方案 97-DC-0180 -人类遗传性听力障碍的遗传分析 01-DC-0099 -NIDCD头颈外科分支临床研究方案评价 01-DC-0228 -前庭水管扩大（伊娃）相关听力损伤的临床和分子分析 01-DC-0229-遗传性听力和平衡障碍的遗传分析 17-DC-0138 -顺铂和他汀类药物治疗耳毒性 18-DC-0051 - NIDCD生物标本方案 NIDCD临床研究和护理核心每年支持3 000多个门诊诊所评估。核心耳鼻喉科医生每年进行50-100例大手术。在高级临床实习期间，工作人员指导医学生。耳鼻喉科外科医生科学家职业发展计划通过OCD协调，在过去的一年中招募了两名候选人。 选定的协作报告： Gochuico BR，齐格勒SG，Ten NS，Balanda NJ，Mason CE，Zumbo P，Evans CA，货车Waes C，Gahl WA，Malicdan MCV.一种全面的，多学科的，精确的医学方法，以发现有效治疗未诊断的，进行性的，纤维炎症性疾病Transl res.2020 Jan;215：31-40. doi：10.1016/j.trsl.2019.08.008。Epub 2019 Aug 28. King KA，Ansari G，Panackal AA，Zalewski C，Anjum S，班尼特JE，Beri A，Kim HJ，Hammoud D，Brewer CC，威廉姆森PR.非HIV既往健康患者中隐球菌脑膜脑炎的听力学和耳科并发症。Otol Neurotol。2019年7月;40（6）：e657-e664。doi：10.1097/MAO.00000000002242。