FASEB SRC: The Protein Lipidation Conference: Enzymology, Signaling, and Therapeutics

FASEB SRC：蛋白质脂化会议：酶学、信号传导和治疗学

• 批准号: 10468574
• 负责人: James Hougland
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-06 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10468574
• 关键词: Academy; Acylation; American; Animals; Area; Biochemistry; Biology; COVID-19 pandemic; Cell physiology; Cellular biology; Chemistry; Clinical Medicine; Collaborations; Communicable Diseases; Communities; Data; Development; Disease; Elevator; Enzymatic Biochemistry; Enzymes; Equilibrium; Event; Fees; Foundations; Funding; GTP-Binding Proteins; Grant; Health; Human; International; Intracellular Transport; Knowledge; Left; Length; Letters; Lipids; Malignant Neoplasms; Membrane; Methodological Studies; Methodology; Modification; Monomeric GTP-Binding Proteins; Pathway interactions; Physiological Processes; Play; Postdoctoral Fellow; Process; Protein Biosynthesis; Protein Isoprenylation; Proteins; Recording of previous events; Reporting; Research; Research Personnel; Rivers; Role; Scientist; Signal Transduction; Slide; Societies; Structure; Students; Synthesis Chemistry; Therapeutic; Training; Travel; Underrepresented Populations; Universities; Vermont; Virginia; Woman; Work; age related; base; career development; clinical development; effective therapy; flexibility; follow-up; graduate student; human disease; immune function; interest; lecturer; lectures; meetings; member; men; next generation; novel; posters; preclinical development; prenylation; programs; structural biology; summer research; supportive environment; symposium; targeted agent; therapeutic target; tool; translational study

PROJECT SUMMARY/ABSTRACT Protein lipidation is a central process in cellular function. Lipidated proteins play critical roles in numerous human diseases including cancer, infectious disease and age-related disorders. We request funds to partially support the Federation of American Societies of Experimental Biology (FASEB) conference on “Protein Lipidation: Enzymology, Signaling and Therapeutics” that will be held from July 31 – August 5, 2022 at Vermont Academy in Saxtons River, VT. Historically, this meeting has brought together scientists in fields ranging from mechanisms and consequences of acylation, prenylation, and post-prenylation processing of proteins, the synthesis and transport of intracellular lipids, and the importance of protein-lipid interactions for cellular signaling in specialized membrane domains. This meeting is the only international venue where these broad but closely interrelated topics are discussed at length and is the first choice for many scientists. As the field has grown over the past sixteen years, it has become highly interdisciplinary and this unique meeting allows scientists from different areas of specialization, ranging from synthetic chemistry to clinical medicine, to come together and discuss new ideas and form new collaborations. Our confirmed keynote speaker is Maurine Linder, Cornell University who will present a lecture entitled “Fatty acyl tales of G proteins and PATs”. The conference is organized around four interrelated themes. First, it will showcase recent advances in structural biology and enzymology of enzymes involved in protein lipid modification. Second, new developments concerning the roles of lipid modifications in various physiological processes and diseases will be reported including cancer, infectious disease and age- related disorders. Third, new methodologies for studying protein lipidation and lipidated proteins will be presented. Finally, recent therapeutic efforts targeting protein lipidation will be reported. There will be 9 sessions and 37 speakers, including 14 short talks. Graduate students and postdoctoral fellows will give two-thirds of the short talks, with the other third given by new investigators. We will also include a “Research Snapshots” session in which 10-15 students and postdoctoral fellows who brought posters but were not selected for short talks in the main program will be invited to give a 2 minute elevator pitch. To further increase our impact on students and postdoctoral fellows, two additional events will be held including a career development session and a meet-the- expert session where experts in four areas including chemistry, cell biology, structural biology and animal-based research will answer questions. The funds requested for this meeting will be used primarily to support graduate student and postdoc travel grants and to support the attendance of young investigators and session chairs, particularly those from underrepresented groups within our research community.

项目摘要/摘要 蛋白质脂化是细胞功能的中心过程。脂肪蛋白在许多人类中起关键作用 包括癌症，传染病和与年龄有关的疾病在内的疾病。我们要求资金部分支持 美国实验生物学社会联合会（FASEB）关于“蛋白质脂质化的会议： 酶学，信号和治疗学”将于2022年7月31日至8月5日在佛蒙特学学院举行 在弗吉尼亚州萨克斯顿河。从历史上看，这次会议将科学家汇集了，从机制到机制等等 蛋白质的酰化，前化和丙酰化后处理的后果，合成和 细胞内脂质的转运以及蛋白 - 脂质相互作用在专业中的细胞信号的重要性 膜域。这次会议是唯一一个广泛但密切相关的国际场所 主题是详细讨论的，是许多科学家的首选。随着田野在过去的发展 十六年，它已经成为高度跨学科的，这次独特的会议允许来自不同领域的科学家 专业化，从合成化学到临床医学，共同讨论新想法 并形成新的合作。我们确认的主题演讲者是康奈尔大学的毛琳·林德（Maurine Linder） 介绍了题为“ G蛋白和PATS的脂肪酰基故事”的讲座。会议大约有四个 相互关联的主题。首先，它将展示酶结构生物学和酶学的最新进展 参与蛋白质脂质修饰。其次，有关脂质修饰作用的新发展 将报道各种身体过程和疾病，包括癌症，传染病和年龄 相关疾病。第三，将提出用于研究蛋白质脂化和脂化蛋白的新方法。 最后，将报告针对蛋白质脂化的最近的治疗努力。将有9次会议和37次会议 演讲者，包括14个简短的演讲。研究生和博士后研究员将提供三分之二的短期 会谈，另外三分之一由新调查员进行。我们还将在 有10-15名学生和博士后研究员带来了海报，但没有被选中 将邀请主计划给出2分钟的电梯音高。进一步增加我们对学生的影响 博士后研究员，将举行另外两项活动，包括职业发展会议和一次聚会 - 专家会议，在四个领域的专家，包括化学，细胞生物学，结构生物学和基于动物的专家 研究将回答问题。要求本次会议的资金将主要用于支持毕业生 学生和博士后旅行补助金，并支持年轻调查员和会议主席的出席 特别是来自我们研究社区中代表性不足的群体的人。