FASEB SRC: The Protein Lipidation Conference: Enzymology, Signaling, and Therapeutics

项目总结/摘要 蛋白质脂化是细胞功能的中心过程。脂化蛋白质在许多人类免疫系统中起着关键作用。 疾病，包括癌症、传染病和与年龄有关的疾病。我们要求资金部分支持 美国实验生物学学会联合会（FASEB）关于“蛋白质脂化： 酶学，信号传导和治疗”，将于2022年7月31日至8月5日在佛蒙特学院举行 位于佛蒙特州的萨克顿河。从历史上看，这次会议汇集了从机制到 以及蛋白质的酰化、异戊烯化和异戊烯化后加工的结果， 细胞内脂质的运输，以及蛋白质-脂质相互作用对细胞信号转导的重要性， 膜结构域本次会议是这些广泛但密切相关的问题的唯一国际场所， 主题讨论得很长，是许多科学家的首选。随着该领域在过去的发展， 十六年来，它已经成为高度跨学科的，这个独特的会议允许来自不同领域的科学家 从合成化学到临床医学， 形成新的合作。我们确认的主讲人是康奈尔大学的Maurine Linder， 发表题为“G蛋白和PAT的脂肪酰基故事”的演讲。会议围绕四个 相互关联的主题首先，它将展示酶的结构生物学和酶学的最新进展 参与蛋白质脂质修饰。第二，关于脂质修饰的作用的新进展， 将报道各种生理过程和疾病，包括癌症、传染病和年龄- 相关疾病。第三，将提出研究蛋白质脂化和脂化蛋白质的新方法。 最后，最近的治疗努力，针对蛋白质脂化将报告。将有9个会议和37个 包括14个简短的演讲。研究生和博士后研究员将提供三分之二的短 其他三分之一由新的调查人员提供。我们还将包括一个“研究快照”会议， 其中10-15名学生和博士后研究员谁带来了海报，但没有被选中参加简短的会谈， 主程序将被邀请给一个2分钟的电梯间距。为了进一步提高我们对学生的影响， 博士后研究员，两个额外的活动将举行，包括职业发展会议和会议， 专家会议，专家在四个领域，包括化学，细胞生物学，结构生物学和动物基础 研究将回答问题。本次会议申请的资金将主要用于支持研究生 学生和博士后旅行赠款，并支持年轻研究人员和会议主席的出席， 特别是那些来自我们研究界代表性不足的群体的人。

PROJECT SUMMARY/ABSTRACT Protein lipidation is a central process in cellular function. Lipidated proteins play critical roles in numerous human diseases including cancer, infectious disease and age-related disorders. We request funds to partially support the Federation of American Societies of Experimental Biology (FASEB) conference on “Protein Lipidation: Enzymology, Signaling and Therapeutics” that will be held from July 31 – August 5, 2022 at Vermont Academy in Saxtons River, VT. Historically, this meeting has brought together scientists in fields ranging from mechanisms and consequences of acylation, prenylation, and post-prenylation processing of proteins, the synthesis and transport of intracellular lipids, and the importance of protein-lipid interactions for cellular signaling in specialized membrane domains. This meeting is the only international venue where these broad but closely interrelated topics are discussed at length and is the first choice for many scientists. As the field has grown over the past sixteen years, it has become highly interdisciplinary and this unique meeting allows scientists from different areas of specialization, ranging from synthetic chemistry to clinical medicine, to come together and discuss new ideas and form new collaborations. Our confirmed keynote speaker is Maurine Linder, Cornell University who will present a lecture entitled “Fatty acyl tales of G proteins and PATs”. The conference is organized around four interrelated themes. First, it will showcase recent advances in structural biology and enzymology of enzymes involved in protein lipid modification. Second, new developments concerning the roles of lipid modifications in various physiological processes and diseases will be reported including cancer, infectious disease and age- related disorders. Third, new methodologies for studying protein lipidation and lipidated proteins will be presented. Finally, recent therapeutic efforts targeting protein lipidation will be reported. There will be 9 sessions and 37 speakers, including 14 short talks. Graduate students and postdoctoral fellows will give two-thirds of the short talks, with the other third given by new investigators. We will also include a “Research Snapshots” session in which 10-15 students and postdoctoral fellows who brought posters but were not selected for short talks in the main program will be invited to give a 2 minute elevator pitch. To further increase our impact on students and postdoctoral fellows, two additional events will be held including a career development session and a meet-the- expert session where experts in four areas including chemistry, cell biology, structural biology and animal-based research will answer questions. The funds requested for this meeting will be used primarily to support graduate student and postdoc travel grants and to support the attendance of young investigators and session chairs, particularly those from underrepresented groups within our research community.