FASEB SRC: The Protein Lipidation Conference: Enzymology, Signaling, and Therapeutics

项目概要/摘要 蛋白质脂化是细胞功能的核心过程。脂化蛋白在许多人体中发挥着关键作用 疾病包括癌症、传染病和与年龄相关的疾病。我们请求资金来部分支持 美国实验生物学会联合会 (FASEB) 会议“蛋白质脂化： 酶学、信号传导和治疗”将于 2022 年 7 月 31 日至 8 月 5 日在佛蒙特学院举行 位于佛蒙特州萨克斯顿河。从历史上看，这次会议汇集了从机制等领域的科学家 蛋白质的酰化、异戊二烯化和异戊二烯化后加工的后果、合成和 细胞内脂质的运输，以及蛋白质-脂质相互作用对于专门的细胞信号传导的重要性 膜域。这次会议是唯一一个国际场合，这些广泛但密切相关的 主题被详细讨论，是许多科学家的首选。随着该领域过去的发展 十六年来，它已经变得高度跨学科，这次独特的会议让来自不同领域的科学家 从合成化学到临床医学的各种专业知识齐聚一堂，讨论新想法 并形成新的合作。我们确认的主讲人是康奈尔大学的 Maurine Linder，他将 发表题为“G 蛋白和 PAT 的脂肪酰基故事”的讲座。本次会议围绕四 相互关联的主题。首先，它将展示酶的结构生物学和酶学的最新进展 参与蛋白质脂质修饰。二、脂质修饰作用的新进展 将报告各种生理过程和疾病，包括癌症、传染病和年龄- 相关疾病。第三，将提出研究蛋白质脂化和脂化蛋白质的新方法。 最后，将报告最近针对蛋白质脂化的治疗努力。共有9场，共37场 演讲者，包括 14 场简短的演讲。研究生和博士后将提供三分之二的短片 会谈，另外三分之一由新调查人员提供。我们还将在其中包括“研究快照”会议 其中10-15名携带海报但没有被选中参加简短演讲的学生和博士后 主节目将受邀进行2分钟的电梯演讲。为了进一步增加我们对学生和 博士后研究员，将举行另外两项活动，包括职业发展会议和见面会 化学、细胞生物学、结构生物学和动物基础等四个领域的专家参加的专家会议 研究会回答问题。本次会议申请的资金将主要用于支持研究生 学生和博士后旅费补助并支持年轻研究者和会议主席的出席， 特别是那些来自我们研究界中代表性不足的群体的人。

PROJECT SUMMARY/ABSTRACT Protein lipidation is a central process in cellular function. Lipidated proteins play critical roles in numerous human diseases including cancer, infectious disease and age-related disorders. We request funds to partially support the Federation of American Societies of Experimental Biology (FASEB) conference on “Protein Lipidation: Enzymology, Signaling and Therapeutics” that will be held from July 31 – August 5, 2022 at Vermont Academy in Saxtons River, VT. Historically, this meeting has brought together scientists in fields ranging from mechanisms and consequences of acylation, prenylation, and post-prenylation processing of proteins, the synthesis and transport of intracellular lipids, and the importance of protein-lipid interactions for cellular signaling in specialized membrane domains. This meeting is the only international venue where these broad but closely interrelated topics are discussed at length and is the first choice for many scientists. As the field has grown over the past sixteen years, it has become highly interdisciplinary and this unique meeting allows scientists from different areas of specialization, ranging from synthetic chemistry to clinical medicine, to come together and discuss new ideas and form new collaborations. Our confirmed keynote speaker is Maurine Linder, Cornell University who will present a lecture entitled “Fatty acyl tales of G proteins and PATs”. The conference is organized around four interrelated themes. First, it will showcase recent advances in structural biology and enzymology of enzymes involved in protein lipid modification. Second, new developments concerning the roles of lipid modifications in various physiological processes and diseases will be reported including cancer, infectious disease and age- related disorders. Third, new methodologies for studying protein lipidation and lipidated proteins will be presented. Finally, recent therapeutic efforts targeting protein lipidation will be reported. There will be 9 sessions and 37 speakers, including 14 short talks. Graduate students and postdoctoral fellows will give two-thirds of the short talks, with the other third given by new investigators. We will also include a “Research Snapshots” session in which 10-15 students and postdoctoral fellows who brought posters but were not selected for short talks in the main program will be invited to give a 2 minute elevator pitch. To further increase our impact on students and postdoctoral fellows, two additional events will be held including a career development session and a meet-the- expert session where experts in four areas including chemistry, cell biology, structural biology and animal-based research will answer questions. The funds requested for this meeting will be used primarily to support graduate student and postdoc travel grants and to support the attendance of young investigators and session chairs, particularly those from underrepresented groups within our research community.