Electrical spectral imaging using magnetic resonance methods
使用磁共振方法进行电光谱成像
基本信息
- 批准号:10468820
- 负责人:
- 金额:$ 23.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAmplifiersAnimalsAreaBiologicalBiophysicsBrainBrain NeoplasmsBrain PathologyBrain imagingCaliberCardiacCell Culture TechniquesCell DensityCell ShapeCell SizeCellsCharacteristicsComputer ModelsContralateralCustomDataDependenceDevelopmentDiagnosisDiffusionDiseaseElectric ConductivityElectric StimulationElectricityElectrolytesElectroporationElectroporation TherapyEvaluationFrequenciesGlioblastomaGliomaHumanImageIn VitroIschemic StrokeKnowledgeLettersMagnetic ResonanceMagnetic Resonance ImagingMagnetismMalignant NeoplasmsMalignant neoplasm of brainMeasurableMeasurementMeasuresMediatingMembraneMethodsMitoticModelingMonitorPathologicPhaseProceduresProcessPropertyRattusReportingResearchSamplingScanningSensitivity and SpecificityShort Interspersed Nucleotide ElementsSignal TransductionSourceSpectrum AnalysisStainsTechniquesTestingTimeTissuesTreatment EfficacyTumor TissueValidationVariantVascularizationWorkanalogbasecancer cellcancer diagnosiscancer imagingcancer therapycontrast enhanceddensitydesign and constructiondiagnostic tooldigitalelectric impedanceelectrical impedance tomographyelectrical propertyhigh resolution imaginghuman subjectimaging modalityimaging propertiesimprovedin vivoinnovationinterestneoplastic cellneuroregulationnon-invasive imagingnoninvasive diagnosisnovelprogramsprospectivereconstructionresponsesimulationspectrographtissue phantomtooltreatment planningtumorunilamellar vesiclevector
项目摘要
The low-frequency electrical properties of biological tissue provide sensitive and valuable indications of cell
density, membrane properties, electrolyte concentrations and mobilities and the presence or absence of
disease, particularly at frequencies between 1 kHz and 1 MHz. Measurements of variations in these properties
between these frequencies provide a unique view of tissue state. Imaging of electrical properties, combined
with electrical spectroscopy, would allow subtle examination of both spatial and time-dependent tissue
characteristics that are important in the diagnosis and therapy of brain cancers. Unfortunately, relatively few
reports of tissue electrical properties are in this frequency range, because they involve invasive and often
error-prone procedures.
Several Magnetic Resonance Imaging (MRI)-based, non-invasive methods of imaging electrical property
distributions have recently been developed. However, these methods can only be used at high frequencies
(>100 MHz) or very low frequencies (<100 Hz). For example, the technique of Diffusion Tensor Magnetic
Resonance Electrical Impedance Tomography (DT-MREIT) combines MR diffusion tensor and MR phase
images to produce reconstruction of full anisotropic conductivity tensor images at very low frequencies.
However, present DT-MREIT techniques are restricted to measurement frequencies of around 10 Hz.
We now propose transforming MREIT methods to capture spectral effects over the frequency range from 10
Hz to 500 kHz. The new technique, multifrequency MREIT (MF-MREIT) will be validated using computational
models, cell and tissue phantoms and in-vivo using a rat model of brain cancer. The specific focus of the
project will be measuring and characterizing low-frequency electrical properties of cancer cell cultures and
tumors grown from these cells in rat brains. It is anticipated that these measurements will lead to better
understanding of tumor properties and aid in planning new electrical therapies that are increasingly being used
to successfully treat brain tumors. The technique will have further application in diverse areas, including
characterization of tissue responses to tumor treating fields, irreversible electroporation therapy, and
measurement of tissue properties for construction of accurate computational models used in planning
neuromodulation treatments.
生物组织的低频电学特性提供了敏感而有价值的细胞指示
项目成果
期刊论文数量(0)
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{{ truncateString('ROSALIND J SADLEIR', 18)}}的其他基金
Electrical spectral imaging using magnetic resonance methods
使用磁共振方法进行电光谱成像
- 批准号:
10309280 - 财政年份:2021
- 资助金额:
$ 23.57万 - 项目类别:
Direct functional imaging of electrical brain stimulation
脑电刺激的直接功能成像
- 批准号:
8505956 - 财政年份:2014
- 资助金额:
$ 23.57万 - 项目类别:
In vivo imaging of therapeutic electric current flow
治疗电流的体内成像
- 批准号:
8584055 - 财政年份:2014
- 资助金额:
$ 23.57万 - 项目类别:
Direct functional imaging of electrical brain stimulation
脑电刺激的直接功能成像
- 批准号:
9024627 - 财政年份:2014
- 资助金额:
$ 23.57万 - 项目类别:
In vivo imaging of therapeutic electric current flow
治疗电流的体内成像
- 批准号:
8853958 - 财政年份:2014
- 资助金额:
$ 23.57万 - 项目类别:
Direct functional imaging of electrical brain stimulation
脑电刺激的直接功能成像
- 批准号:
8816151 - 财政年份:2014
- 资助金额:
$ 23.57万 - 项目类别:
Detection and Quantification of Neonatal Intraventricular Hemorrhage
新生儿脑室内出血的检测和定量
- 批准号:
8539858 - 财政年份:2012
- 资助金额:
$ 23.57万 - 项目类别:
Detection and Quantification of Neonatal Intraventricular Hemorrhage
新生儿脑室内出血的检测和定量
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8394459 - 财政年份:2012
- 资助金额:
$ 23.57万 - 项目类别:
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