权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Electrical spectral imaging using magnetic resonance methods

使用磁共振方法进行电光谱成像

基本信息

批准号：
10468820
负责人：
ROSALIND J SADLEIR
金额：
$ 23.57万
依托单位：
ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10468820
关键词：
3-Dimensional Amplifiers Animals Area Biological Biophysics Brain Brain Neoplasms Brain Pathology Brain imaging Caliber Cardiac Cell Culture Techniques Cell Density Cell Shape Cell Size Cells Characteristics Computer Models Contralateral Custom Data Dependence Development Diagnosis Diffusion Disease Electric Conductivity Electric Stimulation Electricity Electrolytes Electroporation Electroporation Therapy Evaluation Frequencies Glioblastoma Glioma Human Image In Vitro Ischemic Stroke Knowledge Letters Magnetic Resonance Magnetic Resonance Imaging Magnetism Malignant Neoplasms Malignant neoplasm of brain Measurable Measurement Measures Mediating Membrane Methods Mitotic Modeling Monitor Pathologic Phase Procedures Process Property Rattus Reporting Research Sampling Scanning Sensitivity and Specificity Short Interspersed Nucleotide Elements Signal Transduction Source Spectrum Analysis Stains Techniques Testing Time Tissues Treatment Efficacy Tumor Tissue Validation Variant Vascularization Work analog base cancer cell cancer diagnosis cancer imaging cancer therapy contrast enhanced density design and construction diagnostic tool digital electric impedance electrical impedance tomography electrical property high resolution imaging human subject imaging modality imaging properties improved in vivo innovation interest neoplastic cell neuroregulation non-invasive imaging noninvasive diagnosis novel programs prospective reconstruction response simulation spectrograph tissue phantom tool treatment planning tumor unilamellar vesicle vector

项目摘要

The low-frequency electrical properties of biological tissue provide sensitive and valuable indications of cell density, membrane properties, electrolyte concentrations and mobilities and the presence or absence of disease, particularly at frequencies between 1 kHz and 1 MHz. Measurements of variations in these properties between these frequencies provide a unique view of tissue state. Imaging of electrical properties, combined with electrical spectroscopy, would allow subtle examination of both spatial and time-dependent tissue characteristics that are important in the diagnosis and therapy of brain cancers. Unfortunately, relatively few reports of tissue electrical properties are in this frequency range, because they involve invasive and often error-prone procedures. Several Magnetic Resonance Imaging (MRI)-based, non-invasive methods of imaging electrical property distributions have recently been developed. However, these methods can only be used at high frequencies (>100 MHz) or very low frequencies (<100 Hz). For example, the technique of Diffusion Tensor Magnetic Resonance Electrical Impedance Tomography (DT-MREIT) combines MR diffusion tensor and MR phase images to produce reconstruction of full anisotropic conductivity tensor images at very low frequencies. However, present DT-MREIT techniques are restricted to measurement frequencies of around 10 Hz. We now propose transforming MREIT methods to capture spectral effects over the frequency range from 10 Hz to 500 kHz. The new technique, multifrequency MREIT (MF-MREIT) will be validated using computational models, cell and tissue phantoms and in-vivo using a rat model of brain cancer. The specific focus of the project will be measuring and characterizing low-frequency electrical properties of cancer cell cultures and tumors grown from these cells in rat brains. It is anticipated that these measurements will lead to better understanding of tumor properties and aid in planning new electrical therapies that are increasingly being used to successfully treat brain tumors. The technique will have further application in diverse areas, including characterization of tissue responses to tumor treating fields, irreversible electroporation therapy, and measurement of tissue properties for construction of accurate computational models used in planning neuromodulation treatments.

生物组织的低频电学特性提供了敏感而有价值的细胞指示