Public Engagement for Gene Drive Technology

基因驱动技术的公众参与

• 批准号: 10468327
• 负责人: Cinnamon S Bloss
• 金额: $ 45.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-17 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10468327
• 关键词: Address; Affect; Agreement; Area; Catalogs; Communities; Complex; Coupled; Culicidae; Data; Dengue; Development; Disease; Disease Vectors; Documentation; Educational workshop; Effectiveness; Emerging Technologies; Ensure; Environment; Ethics; Foundations; General Population; Genes; Genetic; Genetic Engineering; Geographic Locations; Geography; Glean; Goals; Individual; Infection; Insecticide Resistance; Interdisciplinary Study; International; Intervention; Interview; Leadership; Link; Malaria; Methods; Modification; Mosquito Control; Organism; Persons; Process; Public Health; Publishing; Research; Research Personnel; Research Project Grants; Risk; Safety; Sampling; Series; Site; Social Policies; Structure; Surveys; Target Populations; Technology; Translations; Vector-transmitted infectious disease; Work; ZIKA; base; climate change; design; evidence base; field study; gene drive system; improved; innovation; insight; member; mosquito-borne; multidisciplinary; new technology; novel; novel strategies; product development; response; social; success; tool; vector; vector control

PROJECT SUMMARY Development of gene drives to control mosquito vectors of disease has rapidly accelerated in recent years, and these efforts may soon culminate in gene drive systems ready for open field testing. The success of gene drive and other novel vector control approaches will depend on design decisions, oversight, and plans for field testing and deployment that meet the needs of various stakeholders, including residents of affected areas and the general public, but there is little agreement about how best to obtain informed public input. In a recent analysis of engagement initiatives for novel vector control approaches, our group found that for many initiatives, there was a lack of documentation, and for initiatives that were documented, many had vaguely articulated goals that were not clearly linked to either the methods used or the stage of technological development. The goal of this study is to develop a robust conceptual framework for public engagement to guide the development of gene drives and other emerging technologies from early proof of concept through field trials to deployment. The framework we produce will be generalizable to other novel and exceptional technologies. Each aim of the proposed project is supported by prior published work conducted by our group and observations from preliminary data. In Specific Aim 1, we will conduct a systematic landscape analysis of engagement initiatives for existing novel genetic and other vector control technologies, including gene drive. In Specific Aim 2, we will formulate a public engagement framework that aligns stage of product development with engagement timing, methods, messages, and goals. In Specific Aim 3, we will obtain informed expert and public input on the engagement framework and use the input to refine and finalize the framework. This contribution will be significant because it will provide the foundation for a coherent and comprehensive approach to public engagement for gene drive and other novel and emerging technologies, thereby ensuring the successful translation of novel innovations to address critical public health problems. The approach is innovative in engaging both experts and a demographically and geographically diverse sample of members of the public, including both English and Spanish speakers. The work is feasible in our hands because our team of established investigators has a track record of successful multidisciplinary research projects related to public engagement for novel vector control interventions, as well as expertise in ethical, social, and policy issues related to gene drive.

项目总结 近年来，控制蚊子传播疾病媒介的基因驱动的发展速度迅速加快。 几年后，这些努力可能很快就会达到顶峰，基因驱动系统准备好进行公开领域的测试。的成功之处 基因驱动和其他新的媒介控制方法将取决于设计决策、监督和计划 现场测试和部署，以满足各种利益攸关方的需求，包括受影响地区的居民 和普通公众，但对于如何最好地获得知情的公众意见，几乎没有达成一致意见。在最近一次 在对新型媒介控制方法的参与倡议进行分析后，我们小组发现，对于许多倡议， 缺乏文件，而且对于记录在案的倡议，许多都有含糊的目标 这与所使用的方法或技术发展阶段没有明确的联系。的目标是 这项研究旨在为公众参与制定一个强有力的概念框架，以指导发展 基因驱动和其他新兴技术从早期的概念验证到现场试验 部署。我们产生的框架将可推广到其他新颖和特殊的技术。 拟议项目的每个目标都得到了我们小组先前发表的工作和观察结果的支持 根据初步数据。在具体目标1中，我们将对参与进行系统的景观分析 倡议现有的新型遗传和其他媒介控制技术，包括基因驱动。以特定的目标 2、我们将制定一个公众参与框架，使产品开发阶段与参与保持一致 时机、方法、信息和目标。在具体目标3中，我们将听取知情的专家和公众对 参与框架，并使用输入来改进和最终确定框架。这一贡献将是巨大的。 因为它将为公众参与提供连贯和全面的基础 基因驱动和其他新颖的新兴技术，从而确保小说的成功翻译 解决重大公共卫生问题的创新。该方法在吸引专家和 在人口统计和地理上不同的公众成员样本，包括英语和 会说西班牙语的人。这项工作在我们手中是可行的，因为我们的老牌调查团队有一个 与公众参与新病媒控制相关的成功多学科研究项目的记录 干预措施，以及与基因驱动有关的伦理、社会和政策问题方面的专业知识。