Public Engagement for Gene Drive Technology

项目摘要 近年来，用于控制疾病蚊子载体的基因驱动的开发迅速加速。 这些努力可能很快就会在基因驱动系统中达到高潮，准备进行开放现场测试。的成功 基因驱动和其他新的矢量控制方法将取决于设计决策，监督和计划， 现场测试和部署，满足包括受影响地区居民在内的各利益攸关方的需求 和公众，但对于如何最好地获得知情的公众投入，几乎没有达成一致意见。在最近的一 对新的病媒控制方法的参与倡议的分析，我们的小组发现，对于许多倡议， 缺乏文件记录，而且对于有文件记录的倡议，许多倡议的目标都很模糊 这与所使用的方法或技术发展阶段没有明确的联系。的目标 这项研究旨在为公众参与制定一个健全的概念框架， 基因驱动和其他新兴技术，从早期的概念验证到田间试验， 部署.我们产生的框架将推广到其他新颖和特殊的技术。 建议项目的每个目标都得到了我们小组先前发表的工作和观察的支持 初步数据。在具体目标1中，我们将对参与进行系统的景观分析 （c）为现有的新的遗传和其他病媒控制技术，包括基因驱动，采取主动行动。具体目标 2.我们会制订公众参与架构，使产品开发阶段与公众参与程度一致 时机、方法、信息和目标。在具体目标3中，我们将征求专家和公众对 参与框架，并使用投入来完善和最终确定框架。这一贡献将是巨大的 因为它将为公众参与提供一个连贯和全面的方法， 基因驱动和其他新兴技术，从而确保成功翻译的新的 创新以解决关键的公共卫生问题。这一方法在吸引专家和 一个人口和地理上多样化的公众样本，包括英语和 西班牙语。这项工作在我们手中是可行的，因为我们的既定调查人员团队有一个跟踪 与公众参与新型病媒控制有关的多学科研究项目的成功记录 干预措施，以及与基因驱动相关的伦理，社会和政策问题的专业知识。

PROJECT SUMMARY Development of gene drives to control mosquito vectors of disease has rapidly accelerated in recent years, and these efforts may soon culminate in gene drive systems ready for open field testing. The success of gene drive and other novel vector control approaches will depend on design decisions, oversight, and plans for field testing and deployment that meet the needs of various stakeholders, including residents of affected areas and the general public, but there is little agreement about how best to obtain informed public input. In a recent analysis of engagement initiatives for novel vector control approaches, our group found that for many initiatives, there was a lack of documentation, and for initiatives that were documented, many had vaguely articulated goals that were not clearly linked to either the methods used or the stage of technological development. The goal of this study is to develop a robust conceptual framework for public engagement to guide the development of gene drives and other emerging technologies from early proof of concept through field trials to deployment. The framework we produce will be generalizable to other novel and exceptional technologies. Each aim of the proposed project is supported by prior published work conducted by our group and observations from preliminary data. In Specific Aim 1, we will conduct a systematic landscape analysis of engagement initiatives for existing novel genetic and other vector control technologies, including gene drive. In Specific Aim 2, we will formulate a public engagement framework that aligns stage of product development with engagement timing, methods, messages, and goals. In Specific Aim 3, we will obtain informed expert and public input on the engagement framework and use the input to refine and finalize the framework. This contribution will be significant because it will provide the foundation for a coherent and comprehensive approach to public engagement for gene drive and other novel and emerging technologies, thereby ensuring the successful translation of novel innovations to address critical public health problems. The approach is innovative in engaging both experts and a demographically and geographically diverse sample of members of the public, including both English and Spanish speakers. The work is feasible in our hands because our team of established investigators has a track record of successful multidisciplinary research projects related to public engagement for novel vector control interventions, as well as expertise in ethical, social, and policy issues related to gene drive.