Community-based Participatory Design of an HPV rapid diagnostic test for cervical cancer screening in South Florida

南佛罗里达州基于社区的宫颈癌筛查 HPV 快速诊断测试设计

• 批准号: 10468808
• 负责人: Natalia Maria Rodriguez
• 金额: $ 16.9万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10468808
• 关键词: Active Learning; Address; Adoption; Age-Years; American; Automobile Driving; Award; Biomedical Engineering; Cancer Detection; Cancer Diagnostics; Caring; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cervical; Cervical Cancer Screening; Cessation of life; Clinical Sciences; Clinical Trials; Communities; Community Health; Community Health Aides; Comprehensive Cancer Center; Country; Cytology; DNA; Data; Detection; Development; Development Plans; Diagnostic Reagent Kits; Diagnostic tests; Doctor of Philosophy; Ensure; Equipment; Excision; Face; Feedback; Florida; Future; Geography; Goals; HPV-High Risk; Health; Health Personnel; Health Policy; Health Sciences; Health Technology; Health system; Home; Hour; Human; Human Papilloma Virus Vaccination; Human Papillomavirus; Human Resources; Incidence; Income; Infrastructure; Institutes; Intervention; Knowledge; Laboratories; Language; Lead; Legal patent; Lesion; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mentors; Mentorship; Methods; Mind; Molecular Diagnostic Testing; Nanotechnology; Outcome; Population; Poverty Areas; Process; Public Health; Qualitative Methods; Qualitative Research; Randomized Controlled Trials; Rapid diagnostics; Research; Research Assistant; Research Design; Research Methodology; Research Personnel; Research Training; Resource-limited setting; Resources; Running; Sampling; Social support; Technology; Testing; Time; Training; Training Activity; Translational Research; Translations; Underserved Population; United States; Universities; Woman; Work; base; cancer health disparity; career; career development; community based participatory research; design; diagnostic platform; diagnostic tool; effectiveness testing; equipment training; follow-up; global health; health literacy; high risk population; human centered design; human model; implementation science; improved; innovation; innovative technologies; marginalized population; medical schools; medically underserved; molecular diagnostics; mortality; multidisciplinary; point of care; point of care testing; portability; pre-clinical; premalignant; professor; programs; prototype; research and development; screening; screening program; skills; social culture; social exclusion; social structure; success; technology development; translational cancer research; underserved community; uptake; validation studies

PROJECT SUMMARY: Natalia Rodriguez, PhD, MPH, Research Assistant Professor at the University of Miami (UM), is a biomedical engineer and global health researcher whose overarching career goal is to develop and improve upon mechanisms for successful uptake and systemic adoption of innovative cancer detection technologies through human-centered and community-based participatory design, in order to empower community health workforces, strengthen health systems, and improve health outcomes at the population level. There is a pressing and unmet need for an inexpensive HPV rapid diagnostic test (RDT) that is designed with the end-user in mind and amenable to rapid systemic adoption in any given context. The research Dr. Rodriguez proposes entitled, Community-based Participatory Design of a Human Papillomavirus (HPV) Rapid Diagnostic Test for Cervical Cancer Screening in South Florida, combines community-based participatory research (CBPR) methodology and human-centered design with health technology development to inform the design and translation of a rapid, point-of-care HPV molecular diagnostic test for community use in cervical cancer screening. Dr. Rodriguez‘s previous work in technology development, specifically a molecular diagnostic platform for point-of-care testing of HPV, in combination with her current work in health systems and community health worker (CHW) training have prepared her to conduct the proposed research. Dr. Rodriguez proposes training activities that include didactic and experiential learning on: 1) Qualitative research study design and CBPR methodology; 2) Stakeholder engagement and human-centered design principles; 3) Implementation science and translational research; 4) Designing and conducting randomized control trials. The proposed career development plan will build upon her previous training to enhance her trajectory towards an independent investigator in public health and translational sciences. An outstanding multidisciplinary mentorship team will guide Dr. Rodriguez through the proposed research and training goals: Dr. Kobetz has expertise in CBPR, cancer disparities research and clinical trials, Dr. Daunert in molecular diagnostic development, and Dr. Knaul in health systems and policy, stakeholder engagement, and CHW training. The proposed research and career development plan utilize the breadth of resources at UM including the Clinical and Translational Science Institute, the Sylvester Comprehensive Cancer Center, and the laboratory and prototyping facilities and equipment of the Biomedical Nanotechnology Institute at UM (BioNIUM) and UM’s Miller School of Medicine. The strong mentors, collaborators, and resources at UM ensure the success of the proposed research. This award will provide Dr. Rodriguez with the training and preliminary data needed to be successful in a future R01 study to validate the HPV RDT and will facilitate her development into an independent investigator and leader in translational research on cancer diagnostic tools for medically-underserved communities.

项目概要： Natalia Rodriguez，博士，公共卫生硕士，迈阿密大学 (UM) 研究助理教授，生物医学博士 工程师和全球健康研究员，其总体职业目标是开发和改进 成功采用和系统采用创新癌症检测技术的机制 以人为本和以社区为基础的参与式设计，以增强社区卫生工作者的能力， 加强卫生系统，改善人口健康状况。有一个紧迫且未满足的问题 需要一种廉价的 HPV 快速诊断测试 (RDT)，该测试是为最终用户设计的，并且 适合在任何特定情况下快速系统采用。罗德里格斯博士提出的研究题为： 基于社区的人乳头瘤病毒 (HPV) 宫颈快速诊断检测设计 南佛罗里达州的癌症筛查结合了基于社区的参与性研究 (CBPR) 方法 以人为本的设计与健康技术的发展相结合，为设计和翻译提供快速、 供社区用于宫颈癌筛查的护理点 HPV 分子诊断测试。 Rodriguez 博士之前在技术开发方面的工作，特别是分子诊断平台 结合她目前在卫生系统和社区卫生领域的工作，进行 HPV 即时检测 工人（CHW）培训使她做好了进行拟议研究的准备。罗德里格斯博士建议进行培训 活动包括以下方面的教学和体验式学习：1) 定性研究设计和 CBPR 方法论； 2）利益相关者参与和以人为本的设计原则； 3）实施科学 和转化研究； 4）设计和进行随机对照试验。拟定职业 发展计划将以她之前的培训为基础，以增强她走向独立的轨迹 公共卫生和转化科学研究员。 杰出的多学科导师团队将指导罗德里格斯博士完成拟议的研究 和培训目标：Kobetz 博士拥有 CBPR、癌症差异研究和临床试验方面的专业知识，Daunert 博士 Knaul 博士在卫生系统和政策、利益相关者参与和 社区卫生工作者培训。拟议的研究和职业发展计划利用了密歇根大学的广泛资源 包括临床和转化科学研究所、西尔维斯特综合癌症中心和 密歇根大学生物医学纳米技术研究所 (BioNIUM) 的实验室和原型设施和设备 和密歇根大学米勒医学院。 密歇根大学强大的导师、合作者和资源确保了拟议研究的成功。 该奖项将为罗德里格斯博士提供未来取得成功所需的培训和初步数据 R01 研究旨在验证 HPV RDT，并将促进她发展成为一名独立研究者和 为医疗服务不足的社区提供癌症诊断工具转化研究的领导者。