Community-based Participatory Design of a Human Papillomavirus (HPV) Rapid Diagnostic Test for Cervical Cancer Screening in South Florida

南佛罗里达州基于社区的人乳头瘤病毒 (HPV) 宫颈癌筛查快速诊断测试设计

• 批准号: 10118419
• 负责人: Natalia Maria Rodriguez
• 金额: $ 7.18万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10118419
• 关键词: Active Learning; Address; Adoption; Anthropology; Award; Bedside Testings; Biomedical Engineering; Cancer Detection; Cancer Diagnostics; Caring; Cervical Cancer Screening; Clinical Sciences; Clinical Trials; Communities; Community Health; Community Health Aides; Data; Development; Development Plans; Diagnostic tests; Doctor of Philosophy; Ensure; Epidemiology; Florida; Future; Goals; Health; Health Personnel; Health Sciences; Health Technology; Health system; Human; Human Papillomavirus; Human Resources; Indiana; Infrastructure; Institutes; Mentors; Mentorship; Methods; Mind; Molecular Diagnostic Testing; Outcome; Population; Public Health; Purdue Cancer Center; Qualitative Research; Randomized; Research; Research Design; Research Methodology; Research Personnel; Research Training; Resources; Technology; Testing; Training; Training Activity; Translational Research; Translations; Universities; Work; base; cancer health disparity; career; career development; community based participatory research; control trial; design; equipment training; follow-up; global health; implementation science; improved; innovation; medically underserved; molecular diagnostics; multidisciplinary; point of care; professor; prototype; research and development; social culture; social structure; success; technology development; tool; uptake

PROJECT SUMMARY: Natalia Rodriguez, PhD, MPH, Assistant Professor of Public Health at Purdue University, is a biomedical engineer and global health researcher whose overarching career goal is to develop and improve upon mechanisms for successful uptake and systemic adoption of innovative cancer detection technologies through human-centered and community-based participatory design, in order to empower community health workforces, strengthen health systems, and improve health outcomes at the population level. There is a pressing and unmet need for an inexpensive HPV rapid diagnostic test (RDT) that is designed with the end-user in mind and amenable to rapid systemic adoption in any given context. The research Dr. Rodriguez proposes entitled, Community-based Participatory Design of a Human Papillomavirus (HPV) Rapid Diagnostic Test for Cervical Cancer Screening in South Florida, combines community-based participatory research (CBPR) methodology and human-centered design with health technology development to inform the design and translation of a rapid, point-of-care HPV molecular diagnostic test for community use in cervical cancer screening. Dr. Rodriguez‘s previous work in technology development, specifically a molecular diagnostic platform for point-of-care testing of HPV, in combination with her current work in health systems and community health worker (CHW) training have prepared her to conduct the proposed research. Dr. Rodriguez proposes training activities that include didactic and experiential learning on: 1) Qualitative research study design and CBPR methodology; 2) Stakeholder engagement and human-centered design principles; 3) Implementation science and translational research; 4) Designing and conducting randomized control trials. The proposed career development plan will build upon her previous training to enhance her trajectory towards an independent investigator in public health and translational sciences. An outstanding multidisciplinary mentorship team will guide Dr. Rodriguez through the proposed research and training goals: Dr. Kobetz has expertise in CBPR, cancer disparities research and clinical trials, Dr. Daunert in molecular diagnostic development, and Dr. Forman in epidemiology and anthropology. The proposed research and career development plan utilize the breadth of resources at Purdue including the Indiana Clinical and Translational Science Institute, the Purdue Cancer Center, and the biomedical innovation and translation resources of Discovery Park. The strong mentors, collaborators, and resources at Purdue ensure the success of the proposed research. This award will provide Dr. Rodriguez with the training and preliminary data needed to be successful in a future R01 study to validate the HPV RDT and will facilitate her development into an independent investigator and leader in translational research on cancer diagnostic tools for medically-underserved communities.

项目概要： 娜塔莉亚罗德里格斯，博士，公共卫生硕士，普渡大学公共卫生助理教授，是一个生物医学 工程师和全球健康研究员，其总体职业目标是开发和改进 成功吸收和系统采用创新癌症检测技术的机制， 以人为本和基于社区的参与性设计，以增强社区卫生工作人员的能力， 加强卫生系统，改善人口一级的卫生成果。有一个紧迫的和未满足的 需要一种廉价的HPV快速诊断测试（RDT），其设计考虑到最终用户， 适合在任何特定环境下快速系统地采用。罗德里格斯博士提出的研究题目是， 以社区为基础的人乳头瘤病毒（HPV）宫颈癌快速诊断试验的初步设计 在南佛罗里达的癌症筛查，结合社区参与式研究（CBPR）方法 和以人为本的设计与健康技术的发展，通知设计和翻译的快速， 宫颈癌筛查中社区使用的床旁HPV分子诊断测试。 Rodriguez博士以前在技术开发方面的工作，特别是分子诊断平台 结合她目前在卫生系统和社区卫生方面的工作， 工人（CHW）培训已经准备好她进行拟议的研究。罗德里格斯博士建议 包括教学和体验学习的活动：1）定性研究设计和CBPR 方法论; 2）利益相关者参与和以人为本的设计原则; 3）实施科学 4）设计和实施随机对照试验。提议的职业 发展计划将建立在她以前的培训，以加强她的轨迹走向独立 公共卫生和转化科学研究员。 一个杰出的多学科导师团队将指导罗德里格斯博士通过拟议的研究 和培训目标：Kobetz博士在CBPR，癌症差异研究和临床试验方面具有专业知识，Daunert博士 分子诊断学的发展，以及流行病学和人类学的福尔曼博士。拟议研究 和职业发展计划利用普渡大学的广泛资源，包括印第安纳州临床和 翻译科学研究所，普渡癌症中心，以及生物医学创新和翻译 探索公园的资源。 普渡大学强大的导师，合作者和资源确保了拟议的成功。 research.该奖项将为罗德里格斯博士提供成功所需的培训和初步数据 在未来的R 01研究中验证HPV RDT，并将促进她发展成为独立的研究者 在癌症诊断工具的转化研究中处于领先地位，为医疗服务不足的社区提供帮助。