Community-based Participatory Design of an HPV rapid diagnostic test for cervical cancer screening in South Florida

南佛罗里达州基于社区的宫颈癌筛查 HPV 快速诊断测试设计

• 批准号: 10021625
• 负责人: Natalia Maria Rodriguez
• 金额: $ 16.9万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10021625
• 关键词: Active Learning; Address; Adoption; Age-Years; American; Automobile Driving; Award; Bedside Testings; Biomedical Engineering; Cancer Detection; Cancer Diagnostics; Caring; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cervical; Cervical Cancer Screening; Cessation of life; Clinical Sciences; Clinical Trials; Communities; Community Health; Community Health Aides; Comprehensive Cancer Center; Country; Cytology; DNA; Data; Detection; Development; Development Plans; Diagnostic tests; Doctor of Philosophy; Ensure; Equipment; Excision; Face; Feedback; Florida; Future; Geography; Goals; HPV-High Risk; Health; Health Personnel; Health Policy; Health Sciences; Health Technology; Health system; Home environment; Hour; Human; Human Papilloma Virus Vaccination; Human Papillomavirus; Human Resources; Incidence; Income; Infrastructure; Institutes; Intervention; Knowledge; Laboratories; Language; Lead; Legal patent; Lesion; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mentors; Mentorship; Methods; Mind; Molecular Diagnostic Testing; Nanotechnology; Outcome; Population; Poverty Areas; Process; Public Health; Qualitative Methods; Qualitative Research; Randomized; Research; Research Assistant; Research Design; Research Methodology; Research Personnel; Research Training; Resources; Running; Sampling; Social support; Technology; Testing; Time; Training; Training Activity; Translational Research; Translations; Underserved Population; United States; Universities; Woman; Work; base; cancer health disparity; career; career development; community based participatory research; control trial; design; effectiveness testing; equipment training; follow-up; global health; health literacy; high risk population; human model; implementation science; improved; innovation; innovative technologies; medical schools; medically underserved; molecular diagnostics; mortality; multidisciplinary; point of care; portability; pre-clinical; premalignant; professor; programs; prototype; research and development; screening; screening program; skills; social culture; social exclusion; social structure; success; technology development; tool; translational cancer research; uptake; validation studies

PROJECT SUMMARY: Natalia Rodriguez, PhD, MPH, Research Assistant Professor at the University of Miami (UM), is a biomedical engineer and global health researcher whose overarching career goal is to develop and improve upon mechanisms for successful uptake and systemic adoption of innovative cancer detection technologies through human-centered and community-based participatory design, in order to empower community health workforces, strengthen health systems, and improve health outcomes at the population level. There is a pressing and unmet need for an inexpensive HPV rapid diagnostic test (RDT) that is designed with the end-user in mind and amenable to rapid systemic adoption in any given context. The research Dr. Rodriguez proposes entitled, Community-based Participatory Design of a Human Papillomavirus (HPV) Rapid Diagnostic Test for Cervical Cancer Screening in South Florida, combines community-based participatory research (CBPR) methodology and human-centered design with health technology development to inform the design and translation of a rapid, point-of-care HPV molecular diagnostic test for community use in cervical cancer screening. Dr. Rodriguez‘s previous work in technology development, specifically a molecular diagnostic platform for point-of-care testing of HPV, in combination with her current work in health systems and community health worker (CHW) training have prepared her to conduct the proposed research. Dr. Rodriguez proposes training activities that include didactic and experiential learning on: 1) Qualitative research study design and CBPR methodology; 2) Stakeholder engagement and human-centered design principles; 3) Implementation science and translational research; 4) Designing and conducting randomized control trials. The proposed career development plan will build upon her previous training to enhance her trajectory towards an independent investigator in public health and translational sciences. An outstanding multidisciplinary mentorship team will guide Dr. Rodriguez through the proposed research and training goals: Dr. Kobetz has expertise in CBPR, cancer disparities research and clinical trials, Dr. Daunert in molecular diagnostic development, and Dr. Knaul in health systems and policy, stakeholder engagement, and CHW training. The proposed research and career development plan utilize the breadth of resources at UM including the Clinical and Translational Science Institute, the Sylvester Comprehensive Cancer Center, and the laboratory and prototyping facilities and equipment of the Biomedical Nanotechnology Institute at UM (BioNIUM) and UM’s Miller School of Medicine. The strong mentors, collaborators, and resources at UM ensure the success of the proposed research. This award will provide Dr. Rodriguez with the training and preliminary data needed to be successful in a future R01 study to validate the HPV RDT and will facilitate her development into an independent investigator and leader in translational research on cancer diagnostic tools for medically-underserved communities.

项目总结： 娜塔莉亚·罗德里格斯，博士，公共卫生硕士，迈阿密大学研究助理教授，生物医学 工程师和全球卫生研究人员，其首要职业目标是发展和改进 成功采用和系统采用创新癌症检测技术的机制 以人为本和以社区为基础的参与式设计，以增强社区卫生工作人员的能力， 加强卫生系统，改善人口健康状况。有一个紧迫而又未得到满足的问题 需要一种廉价的HPV快速诊断检测(RDT)，其设计考虑到了最终用户和 在任何给定的环境中都能迅速系统地采用。罗德里格斯博士提出的这项研究题为， 人乳头瘤病毒(HPV)宫颈快速诊断试验的社区参与式设计 在南佛罗里达州进行癌症筛查，结合社区参与性研究(CBPR)方法 而以人为本的设计随着卫生科技的发展向信息化的设计和翻译快速发展， 社区用于宫颈癌筛查的临床点HPV分子诊断试验。 罗德里格斯博士之前在技术开发方面的工作，特别是分子诊断平台 用于HPV的护理点检测，结合她目前在卫生系统和社区卫生方面的工作 工人(CHW)培训已经为她进行拟议的研究做好了准备。罗德里格斯博士建议培训 包括教学和体验式学习的活动：1)定性研究、研究设计和CBPR 方法论；2)利益相关者参与和以人为本的设计原则；3)实施科学 和转化性研究；4)设计和实施随机对照试验。计划中的职业 发展计划将建立在她之前的培训基础上，以增强她走向独立的轨迹 公共卫生和翻译科学领域的研究人员。 一个杰出的多学科指导团队将指导罗德里格斯博士完成拟议的研究 培训目标：Kobetz博士在CBPR、癌症差异研究和临床试验方面拥有专业知识，Daunert博士 在分子诊断开发方面，以及诺尔博士在卫生系统和政策、利益相关者参与方面，以及 CHW培训。拟议的研究和职业发展计划利用了密歇根大学的广泛资源 包括临床和翻译科学研究所、西尔维斯特综合癌症中心和 UM生物医学纳米技术研究所(BioNIUM)的实验室和原型设施及设备 以及密歇根大学米勒医学院。 密歇根大学强大的导师、合作者和资源确保了拟议研究的成功。 这一奖项将为罗德里格斯博士提供未来成功所需的培训和初步数据 R01研究，以验证HPV RDT，并将促进她发展为独立调查员和 在为医疗服务不足的社区进行癌症诊断工具的翻译研究方面处于领先地位。