Developmental Research Program

发展研究方案--项目摘要 梅奥诊所HBCS孢子发育研究计划(DRP)的目标是吸引、开发、 支持和监测与转化性肝胆癌有关的最有前途和最具创新性的项目 研究。每年DRP将提供三项为期一年的奖励，每项奖励50,000美元，并有可能获得 在显示出重大进展和潜力的基础上再提供一年的支助。一位严谨的同行- 利用内部科学咨询委员会和其他经验丰富的专家进行审查的过程 调查人员将根据以下标准对所有申请进行评估：科学价值、原创性、 申请人/合作调查员(S)的资历和翻译潜力。虽然它的平移轨迹 所有应用程序都需要显而易见，我们鼓励调查所有的高风险/高回报提案 关于肝胆癌的发病率和死亡率的方面，从法官到人群。这 将通过以下具体目标实现：(1)征集和支持创新和 肝胆管的跨学科翻译相关实验室、人口学和临床研究 (2)鼓励招募符合条件的少数群体、妇女和残疾人；(3)提供 对所有DRP申请和获奖进展进行严格评估；以及(4)促进DRP的发展 向R01级应用程序和/或未来的HBCS孢子项目提供资金的提案。预计 对发展研究项目的支持将产生数据，这些数据将作为 额外的重债穷国孢子赞助的项目或通过其他外部同行审查机制提供的支持。 HBCS孢子领导层将与调查人员合作，帮助确保独立的R01级资金。 其中包括三个潜在研究项目的一页提纲，以展示 可通过HBCS孢子发展研究获得资助的正在进行的研究 程序。

DEVELOPMENTAL RESEARCH PROGRAM – PROJECT SUMMARY The goal of the Mayo Clinic HBCs SPORE Developmental Research Program (DRP) is to attract, develop, support, and monitor the most promising and innovative projects pertaining to translational hepatobiliary cancer research. Each year the DRP will provide three, one-year awards of $50,000 each with the possibility of an additional year of support based upon the demonstration of significant progress and potential. A rigorous peer- review process utilizing the expertise of the Internal Scientific Advisory Committee and other experienced investigators will evaluate all applications based upon the following criteria: scientific merit, originality, qualifications of the applicant/co-investigator(s), and translational potential. While the translational trajectory of all applications needs to be readily apparent, we encourage high risk/high payoff proposals investigating all aspects pertaining to the morbidity and mortality of hepatobiliary cancer from the bench to the population. This will be accomplished through the following Specific Aims: (1) Solicit and support innovative and interdisciplinary translationally-relevant laboratory, population science, and clinical studies in hepatobiliary cancer; (2) Encourage the recruitment of qualified minorities, women, and persons with disabilities; (3) Provide critical evaluation of all DRP applications and awardee progress; and (4) Facilitate the development of DRP funded proposals into R01-level applications and/or future HBCs SPORE projects. It is expected that developmental research project support will result in the generation of data that will serve as the basis for additional HBCs SPORE-sponsored projects or support through other external peer-reviewed mechanisms. The HBCs SPORE leadership will work with the investigators to help secure independent R01-level funding. One-page outlines of three potential research projects are included to demonstrate the depth and breadth of ongoing research that can be eligible for funding through the HBCs SPORE Developmental Research Program.