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Mayo Clinic Hepatobiliary SPORE Diversity Supplement Dr. Musa Gabere

Mayo Clinic 肝胆 SPORE 多样性补充剂 Dr. Musa Gabere

基本信息

批准号：
10310895
负责人：
MARK A. MC NIVEN
金额：
$ 13.6万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-10 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10310895
关键词：
African Antigens Award Bacterial Infections Bioinformatics Biological Biological Assay Biological Markers Cancer Patient Caring Cholangiocarcinoma Clinic Clinical Trials Collaborations Colorectal Cancer Coupled Data Data Set Development Doctor of Philosophy Eligibility Determination Emerging Technologies Extramural Activities Foundations Funding Genes Genetic Goals Grant Green Card Heat Stroke Hepatobiliary Immunotherapeutic agent Immunotherapy Kenya Learning Legal patent Machine Learning Malignant Neoplasms Malignant neoplasm of liver Malignant neoplasm of pancreas Master of Science Mathematics Mayo Clinic Cancer Center Mentors Middle East Respiratory Syndrome Minority Musa plant Mycoses Neurology Patients Phase I Clinical Trials Primary carcinoma of the liver cells Prognosis Publishing Research Research Ethics Research Personnel Scholarship Scientist Screening for cancer Secure Series South Africa Supervision Systems Biology Systems Development Therapeutic Agents Training Translational Research Tsetse Flies United States Universities Virotherapy Virus Diseases Visit Work anticancer research antimicrobial peptide artificial neural network base biomarker discovery cancer genetics career doctoral student ethnic minority population exome feature selection hepatobiliary cancer immunotherapeutic virotherapy in silico interest knowledge base mathematical sciences meetings metabolome methylome new technology oncolytic virotherapy parent grant personalized medicine post-doctoral training programs racial minority random forest response support vector machine targeted treatment therapy development transcriptome undergraduate student whole genome

项目摘要

STATEMENT OF CANDIDATE ELIGIBILITY AND DIVERSITY Dr. Musa Gabere is a permanent resident of the United States (Green card number: 063-359-769) of African descent. He completed his undergraduate studies at the University of Nairobi. He then moved to South Africa, where he completed post-graduate diploma, Master of Science and Doctor of Philosophy. Dr. Gabere is interested in applying genetics and bioinformatics approaches to identify common biomarkers that can be used to develop targeted therapies for hepatobiliary cancers. In particular, he will train in understanding the transcriptome changes in hepatocarcinoma treated with immunovirotherapy, a new class of immunotherapeutic. He will be mentored by Dr. Mitesh J. Borad (Primary mentor), Dr. Richard G. Vile (Co- mentor), and Dr. Lewis Roberts (co-mentor) as part of the parent grant 5P50CA210964-03 (P.I. Dr. Richard G. Vile). The overall goal of Dr. Gabere is to pursue research in cancer genetics. Dr. Gabere will participate in various training in Mayo Clinic. These include training in virotherapy, immunotherapy, translational research and ethics. Additionally, there are weekly meetings in cancer, where he can learn and interact with Mayo Clinic Cancer Center senior investigators. In addition, to this, Dr Gabere will have the opportunity to work with large cancer genetics datasets with experts in liver and pancreatic cancer research. These datasets include but not restricted to whole genome, exome, methylome, metabolome and transcriptome for various cancers such as Cholangiocarcinoma. Dr Gabere will also have opportunity to mentor and supervise PhD students and visiting scientists to identify of antigens both in-silico and functional assays. The diversity grant will also allow Dr. Gabere to increase the number of racial and ethnic minorities who participate in biomarker discovery and clinical trials. This will allow Dr Gabere to inform and educate the minorities in the importance of clinical trials and early cancer screening. It is expected that upon receipt of the Diversity Supplement, Dr. Gabere will be able to generate vital data and apply for extramural funding, such as the care award (R21) at the end of his second year.

候选人资格和多样性声明博士Musa Gabere是美国永久居民（绿色卡号：063-359-769），血统.他在内罗毕大学完成了本科学业。然后他搬到了南非，在那里他完成了研究生文凭，理学硕士和哲学博士。博士Gabere感兴趣的是应用遗传学和生物信息学方法来识别常见的生物标志物可用于开发肝胆癌的靶向疗法。特别是，他将在了解免疫病毒疗法治疗肝癌的转录组变化，免疫系统他将由Mitesh J. Borad博士（主要导师）、Richard G.邪恶（Co- 导师）和刘易斯罗伯茨博士（共同导师）作为家长补助金5 P50 CA 210964 -03（P.I. Richard G.博士 Vile）。 Gabere博士的总体目标是从事癌症遗传学研究。加贝尔博士将参加各种在马约诊所接受培训。其中包括病毒治疗、免疫治疗、转化研究和伦理学方面的培训。此外，每周还有癌症方面的会议，在那里他可以学习并与马约癌症诊所互动中心高级研究员。此外，Gabere博士将有机会与大型癌症合作，遗传学数据集与肝癌和胰腺癌研究专家。这些数据集包括但不限于各种癌症的全基因组、外显子组、甲基化组、代谢组和转录组，胆管癌Gabere博士还将有机会指导和监督博士生和访问科学家们通过计算机模拟和功能测定来鉴定抗原。多样性补助金还将使加贝尔博士能够增加少数种族和少数民族的数量，参与生物标志物发现和临床试验。这将使加贝尔博士能够告知和教育少数群体对临床试验和早期癌症筛查的重要性的认识。预计在收到 Gabere博士将能够生成重要数据并申请校外资金，例如在第二年年底获得关怀奖（R21）。