4D Nucleome Network Data Coordination and Integration Center

项目总结 4D核基因组(4DN)数据协调和集成中心(DCIC)的目标是收集、存储、管理 显示和分析在4DN网络中生成的数据。我们已经组建了一支调查小组，工作人员 在染色质相互作用数据分析、图像处理、 数据可视化、基因组和表观基因组数据的综合分析、数据门户开发、大规模 计算，以及安全和fl可扩展云技术的开发。在4DN项目的fi第一阶段， 我们开发了4DN数据门户作为中心资源，提供数据提交、管理、分析等工具 以及质量控制、可视化、探索和下载。该门户提供了易于导航的界面 用于访问原始和中间数据fiLES，允许通过API进行编程访问，并结合了新的 DCIC和其他网络成员开发的分析和可视化工具。在第二阶段， 4DN项目，我们将继续支持4DN网络的研究活动，并领导创建一个 为Sciencefic社区精心策划的4DN数据资源。同时，我们建议加强这方面的效用 以多种方式整合4DNSCHENTIfic数据和数据门户：i.我们将创建一个集成成像的平台 和测序数据，并支持在一个共同坐标系中创建参考核图；二.我们 将通过定制的本体应用程序和 受保护的数据管理；iii.我们将开发新的云平台功能，将用户分析带到 4DN数据门户，并应用成本效益fi效率改进来支持不断增加的数据量；i.我们将表演 定期开展外联活动，以提高对网络和预防犯罪中心产生的数据和工具的认识。 总体而言，我们将确保4DN中生成的数据将对Sciencefic社区产生最大影响。

PROJECT SUMMARY The goals of the 4D Nucleome (4DN) Data Coordination and Integration Center (DCIC) are to collect, store, curate, display, and analyze data generated in the 4DN Network. We have assembled a team of investigators, staff scientists, and developers with a strong track record in analysis of chromatin interaction data, image processing, data visualization, integrative analysis of genomic and epigenomic data, data portal development, large-scale computing, and development of secure and flexible cloud technologies. In the first phase of the 4DN Project, we have developed the 4DN Data Portal as a central resource with tools for data submission, curation, analysis and quality control, visualization, exploration, and download. The portal provides an easy-to-navigate interface for accessing raw and intermediate data files, allows for programmatic access via APIs, and incorporates novel analysis and visualization tools developed by DCIC as well as other Network members. In the second phase of the 4DN Project, we will continue to support the research activities by the 4DN Network, and to lead the creation of a well curated 4DN data resource for the scientific community. At the same time, we propose to enhance the utility of the 4DN Scientific Data and the Data Portal in multiple ways: i. We will create a platform to integrate imaging and sequencing data and support the creating of reference nuclear maps in a common coordinate system; ii. We will provide support for 4DN Projects on Human Health and Disease with customized ontology applications and protected data management; iii. We will develop new cloud platform capabilities to bring user analyses to the 4DN Data Portal, and apply cost-efficiency improvements to support increasing data volumes; iv. We will perform regular outreach activities to raise awareness about the data and tools generated by the Network and DCIC. Overall, we will ensure that the data generated in 4DN will have maximal impact for the scientific community.