4D Nucleome Network Data Coordination and Integration Center

4D核组网络数据协调整合中心

• 批准号: 10468294
• 负责人: Peter J Park
• 金额: $ 250万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-07 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10468294
• 关键词: 3-Dimensional; Architecture; Authorization documentation; Awareness; Biological; Biological Assay; Cell Nucleus; Chromatin; Collection; Communication; Communities; Computer software; Controlled Environment; Cost efficiency; Custom; Data; Data Collection; Data Files; Data Set; Deposition; Development; Disease; Docking; Educational workshop; Ensure; Funding; Gene Expression Regulation; Genomics; Goals; Health; Human; Image; Intake; International; Language; Lead; Maintenance; Maps; Metadata; Microscopy; Monitor; Nuclear; Ontology; Phase; Positioning Attribute; Process; Protocols documentation; Quality Control; Reproducibility; Research; Research Activity; Research Personnel; Research Support; Resources; Role; Sampling; Scientist; Secure; Structure; System; Technology; Time; United States National Institutes of Health; Vision; Visualization; Visualization software; Work; cloud platform; computational pipelines; computerized data processing; data access; data acquisition; data analysis pipeline; data curation; data dissemination; data management; data modeling; data portal; data resource; data sharing; data standards; data submission; data tools; data visualization; design; epigenomics; experience; flexibility; genomic data; image processing; improved; meetings; member; metadata standards; multimodal data; novel; open data; outreach; self organization; software development; symposium; tool; user-friendly; webinar; working group

PROJECT SUMMARY The goals of the 4D Nucleome (4DN) Data Coordination and Integration Center (DCIC) are to collect, store, curate, display, and analyze data generated in the 4DN Network. We have assembled a team of investigators, staff scientists, and developers with a strong track record in analysis of chromatin interaction data, image processing, data visualization, integrative analysis of genomic and epigenomic data, data portal development, large-scale computing, and development of secure and flexible cloud technologies. In the first phase of the 4DN Project, we have developed the 4DN Data Portal as a central resource with tools for data submission, curation, analysis and quality control, visualization, exploration, and download. The portal provides an easy-to-navigate interface for accessing raw and intermediate data files, allows for programmatic access via APIs, and incorporates novel analysis and visualization tools developed by DCIC as well as other Network members. In the second phase of the 4DN Project, we will continue to support the research activities by the 4DN Network, and to lead the creation of a well curated 4DN data resource for the scientific community. At the same time, we propose to enhance the utility of the 4DN Scientific Data and the Data Portal in multiple ways: i. We will create a platform to integrate imaging and sequencing data and support the creating of reference nuclear maps in a common coordinate system; ii. We will provide support for 4DN Projects on Human Health and Disease with customized ontology applications and protected data management; iii. We will develop new cloud platform capabilities to bring user analyses to the 4DN Data Portal, and apply cost-efficiency improvements to support increasing data volumes; iv. We will perform regular outreach activities to raise awareness about the data and tools generated by the Network and DCIC. Overall, we will ensure that the data generated in 4DN will have maximal impact for the scientific community.

项目摘要 4D Nucleome（4DN）数据协调和集成中心（DCIC）的目标是收集，存储，管理， 显示和分析4DN网络中生成的数据。我们已经召集了一队调查人员， 科学家和开发人员在染色质相互作用数据分析，图像处理， 数据可视化，基因组和表观基因组数据的综合分析，数据门户开发，大规模 计算，以及开发安全和灵活的云技术。在4DN项目的第一阶段， 我们开发了4DN数据门户，作为数据提交、管理和分析工具的中心资源 质量控制、可视化、探索和下载。该门户提供了一个易于导航的界面 用于访问原始和中间数据文件，允许通过API进行编程访问， DCIC和其他网络成员开发的分析和可视化工具。第二阶段 4DN项目，我们将继续支持4DN网络的研究活动，并领导创建一个 为科学界精心策划的4DN数据资源。与此同时，我们建议提高 4DN科学数据和数据门户以多种方式：i.我们将创建一个平台， 和测序数据，并支持在共同坐标系中创建参考核图; ii.我们 将为人类健康和疾病的4DN项目提供定制本体应用程序的支持， 受保护的数据管理; iii.我们将开发新的云平台功能，将用户分析带到 4DN数据门户，并应用成本效益改进来支持不断增加的数据量; iv.我们将执行 定期开展外联活动，以提高对网络和数据中心生成的数据和工具的认识。 总的来说，我们将确保4DN产生的数据将对科学界产生最大的影响。