Fox COBRE Phase II Admin Core

项目摘要 管理核心 这个二期科布雷将继续我们中心的工作，开发用于探测生物学的分子方法，以 发现和应用新的化学生物学工具来研究与疾病相关的生物途径，以及 发展了解小分子与络合物相互作用的计算方法 大分子靶标。在第一阶段基础设施和成功的基础上，我们的Cobre将开发新的 了解细菌病原体利用细胞和分子机制的化学生物学工具 在宿主细胞内存活和复制，可用于了解CLP蛋白酶靶标的分子探针 传染病，绘制和理解a‘甲基可逆的mRNA修饰调节的工具 与人类癌症进展有关的橡皮擦酶，分子定义的纳米颗粒佐剂 在肺部产生特定的免疫反应以推进可吸入疫苗的开发，并计算 小分子调控病毒结构和功能机制的研究进展 冰盖。 行政核心的目标是：(1)发展行政、财政和科学方面 拟议的科布雷，包括建立一个领导小组和一项招聘计划；(2)实施 领导团队、内部咨询委员会(IAC)、 导师和外部咨询委员会；(3)实施职业指导计划， 使教师能够制定成功的研究计划，并为他们的工作吸引资金；(4)发展 研究、培训和职业发展目标和能力。成功招聘和留住员工的计划 详细介绍了一项将调查人员过渡到独立状态并继续访问核心的计划 设施和参与科布雷赞助的活动。

Project Summary Administrative Core This Phase II COBRE will continue our center’s work to develop molecular approaches for probing biology, to discover and apply new chemical biology tools for the study of biological pathways associated with disease, and to develop computational approaches for understanding small molecule interactions with complex macromolecular targets. Building on the infrastructure and successes of Phase I, our COBRE will develop new chemical biology tools for understanding the cellular and molecular mechanisms that bacterial pathogens use to survive and replicate inside host cells, molecular probes that can be used to understand Clp protease targets of infectious diseases, tools to map and understand the regulation of reversible mRNA modification by a ‘methyl eraser’ enzyme linked to the progression of human cancers, molecularly-defined nanoparticle adjuvants that yield specific immune responses in the lung to advance inhalable vaccine development, and computational approaches to elucidate the mechanisms by which small molecules regulate the structure and function of virus capsids. The goals of the Administrative Core are (1) Development of the administrative, fiscal and scientific aspects of the proposed COBRE, including establishment of a leadership team and a hiring plan; (2) Implementation of summative and formative evaluation strategies by the Leadership Team, an Internal Advisory Committee (IAC), mentors, and an External Advisory Committee (EAC); (3) Implementation of a Career Guidance Plan that enables faculty to develop successful research programs and to attract funding for their work; (4) Development of research, training & career development goals and capabilities. A plan for hiring and retaining successful faculty is detailed as is a plan for transitioning investigators to independent status with continued access to core facilities and participation in COBRE sponsored events.