Fox COBRE Phase II Admin Core

项目摘要 行政核心 第二阶段COBRE将继续我们中心的工作，开发探测生物学的分子方法， 发现和应用新的化学生物学工具，用于研究与疾病相关的生物学途径， 开发计算方法来理解小分子与复杂分子的相互作用 大分子靶点在基础设施和第一阶段成功的基础上，我们的COBRE将开发新的 化学生物学工具，用于了解细菌病原体用于 在宿主细胞内存活和复制，分子探针可用于了解Clp蛋白酶的靶点， 传染病，工具来映射和了解可逆的mRNA修饰的调节，由一个'甲基 与人类癌症进展有关的擦除酶，分子定义的纳米颗粒佐剂， 在肺部产生特异性免疫反应，以促进可吸入疫苗的开发， 阐明小分子调节病毒结构和功能的机制的方法 衣壳 行政核心的目标是：（1）发展行政、财政和科学方面的能力， 拟议的COBRE，包括建立领导小组和招聘计划;（2）实施 领导小组、内部咨询委员会（IAC）的总结性和形成性评价战略， 导师和外部咨询委员会（EAC）;（3）实施职业指导计划， 使教师能够制定成功的研究计划，并为他们的工作吸引资金;（4）发展 研究，培训和职业发展目标和能力。成功的招聘和留住人才的计划 教师是详细的，因为是一个计划，过渡到独立的地位，继续访问核心调查 设施和参与COBRE赞助的活动。

Project Summary Administrative Core This Phase II COBRE will continue our center’s work to develop molecular approaches for probing biology, to discover and apply new chemical biology tools for the study of biological pathways associated with disease, and to develop computational approaches for understanding small molecule interactions with complex macromolecular targets. Building on the infrastructure and successes of Phase I, our COBRE will develop new chemical biology tools for understanding the cellular and molecular mechanisms that bacterial pathogens use to survive and replicate inside host cells, molecular probes that can be used to understand Clp protease targets of infectious diseases, tools to map and understand the regulation of reversible mRNA modification by a ‘methyl eraser’ enzyme linked to the progression of human cancers, molecularly-defined nanoparticle adjuvants that yield specific immune responses in the lung to advance inhalable vaccine development, and computational approaches to elucidate the mechanisms by which small molecules regulate the structure and function of virus capsids. The goals of the Administrative Core are (1) Development of the administrative, fiscal and scientific aspects of the proposed COBRE, including establishment of a leadership team and a hiring plan; (2) Implementation of summative and formative evaluation strategies by the Leadership Team, an Internal Advisory Committee (IAC), mentors, and an External Advisory Committee (EAC); (3) Implementation of a Career Guidance Plan that enables faculty to develop successful research programs and to attract funding for their work; (4) Development of research, training & career development goals and capabilities. A plan for hiring and retaining successful faculty is detailed as is a plan for transitioning investigators to independent status with continued access to core facilities and participation in COBRE sponsored events.