Fox COBRE Phase II Admin Core
Fox COBRE 第二阶段管理核心
基本信息
- 批准号:10026269
- 负责人:
- 金额:$ 68.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AchievementAdjuvantAdvisory CommitteesAreaAwardBiologicalBiologyBiomedical ResearchCapsidCareer MobilityCellsCenters of Research ExcellenceChemicalsCommunicable DiseasesCore FacilityDevelopmentDiseaseEducational workshopEnzymesEventFacultyFoxesFundingGoalsGrantGroup MeetingsGrowthGrowth and Development functionHIVHumanHuman BiologyImmune responseImmunologyInfrastructureLeadLeadershipLegionnaires&apos DiseaseLinkLungMacromolecular ComplexesMalignant NeoplasmsManuscriptsMapsMentorsMessenger RNAMicrobiologyModelingModificationMolecularMolecular ProbesPathway interactionsPhasePilot ProjectsPostdoctoral FellowPreparationPublicationsRegulationResearchResearch PersonnelResearch TrainingResourcesSeriesStructureStudentsTherapeuticTuberculosisUniversitiesVirusVocational GuidanceWorkWritingcareer developmentchemical synthesiscohortdrug discoveryendopeptidase Clpexperiencefaculty mentorflexibilityformative assessmenthuman diseasemeetingsmembernanoparticlepathogenic bacteriaprogramsrecruitresearch and developmentsmall moleculesuccesssupport networktoolvaccine development
项目摘要
Project Summary
Administrative Core
This Phase II COBRE will continue our center’s work to develop molecular approaches for probing biology, to
discover and apply new chemical biology tools for the study of biological pathways associated with disease, and
to develop computational approaches for understanding small molecule interactions with complex
macromolecular targets. Building on the infrastructure and successes of Phase I, our COBRE will develop new
chemical biology tools for understanding the cellular and molecular mechanisms that bacterial pathogens use to
survive and replicate inside host cells, molecular probes that can be used to understand Clp protease targets of
infectious diseases, tools to map and understand the regulation of reversible mRNA modification by a ‘methyl
eraser’ enzyme linked to the progression of human cancers, molecularly-defined nanoparticle adjuvants that
yield specific immune responses in the lung to advance inhalable vaccine development, and computational
approaches to elucidate the mechanisms by which small molecules regulate the structure and function of virus
capsids.
The goals of the Administrative Core are (1) Development of the administrative, fiscal and scientific aspects of
the proposed COBRE, including establishment of a leadership team and a hiring plan; (2) Implementation of
summative and formative evaluation strategies by the Leadership Team, an Internal Advisory Committee (IAC),
mentors, and an External Advisory Committee (EAC); (3) Implementation of a Career Guidance Plan that
enables faculty to develop successful research programs and to attract funding for their work; (4) Development
of research, training & career development goals and capabilities. A plan for hiring and retaining successful
faculty is detailed as is a plan for transitioning investigators to independent status with continued access to core
facilities and participation in COBRE sponsored events.
项目摘要
行政核心
第二阶段COBRE将继续我们中心的工作,开发探测生物学的分子方法,
发现并应用新的化学生物学工具来研究与疾病相关的生物学途径,以及
开发计算方法来理解小分子与复杂分子的相互作用
大分子靶点在基础设施和第一阶段成功的基础上,我们的COBRE将开发新的
化学生物学工具,用于了解细菌病原体用于
在宿主细胞内存活和复制,分子探针可用于了解Clp蛋白酶的靶点,
传染病,工具来映射和了解可逆的mRNA修饰的调节,由一个'甲基
与人类癌症进展有关的擦除酶,分子定义的纳米颗粒佐剂,
在肺部产生特异性免疫反应,以促进可吸入疫苗的开发,
阐明小分子调节病毒结构和功能的机制的方法
衣壳
行政核心的目标是:(1)发展行政、财政和科学方面的能力,
拟议的COBRE,包括建立领导小组和招聘计划;(2)实施
领导小组、内部咨询委员会(IAC)的总结性和形成性评价战略,
导师和外部咨询委员会(EAC);(3)实施职业指导计划,
使教师能够制定成功的研究计划,并为他们的工作吸引资金;(4)发展
研究,培训和职业发展目标和能力。成功的招聘和留住人才的计划
教师是详细的,因为是一个计划,过渡到独立的地位,继续访问核心调查
设施和参与COBRE赞助的活动。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOSEPH M FOX其他文献
JOSEPH M FOX的其他文献
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{{ truncateString('JOSEPH M FOX', 18)}}的其他基金
Toolkit for Fast, Multipurpose and Inducible Bioorthogonal Chemistry
快速、多用途和诱导生物正交化学工具包
- 批准号:
9899272 - 财政年份:2019
- 资助金额:
$ 68.61万 - 项目类别:
Toolkit for Fast, Multipurpose and Inducible Bioorthogonal Chemistry
快速、多用途和诱导生物正交化学工具包
- 批准号:
10660115 - 财政年份:2019
- 资助金额:
$ 68.61万 - 项目类别:
NIH ADMINISTRATIVE SUPPLEMENT FPLC SYSTEM FOX
NIH 行政补充 FPLC 系统 FOX
- 批准号:
9925864 - 财政年份:2019
- 资助金额:
$ 68.61万 - 项目类别:
Supplement to Toolkit for Fast, Multipurpose and Inducible Bioorthogonal Chemistry
快速、多用途和诱导生物正交化学工具包的补充
- 批准号:
10046448 - 财政年份:2019
- 资助金额:
$ 68.61万 - 项目类别:
Toolkit for Fast, Multipurpose and Inducible Bioorthogonal Chemistry
快速、多用途和诱导生物正交化学工具包
- 批准号:
10343710 - 财政年份:2019
- 资助金额:
$ 68.61万 - 项目类别:
Discovery of Molecular Probes and Therapeutic Leads, Administrative Supplement for Equipment
分子探针和治疗先导物的发现,设备管理补充
- 批准号:
10400299 - 财政年份:2014
- 资助金额:
$ 68.61万 - 项目类别:
Discovery of Chemical Probes and Therapeutic Leads, Phase 2
化学探针和治疗先导化合物的发现,第二阶段
- 批准号:
10853967 - 财政年份:2014
- 资助金额:
$ 68.61万 - 项目类别:
Discovery of Chemical Probes and Therapeutic Leads, Phase II
化学探针和治疗先导化合物的发现,第二阶段
- 批准号:
10654734 - 财政年份:2014
- 资助金额:
$ 68.61万 - 项目类别:
Discovery of Chemical Probes and Therapeutic Leads: Cryoprobe Upgrade of a 400 MHz NMR
化学探针和治疗先导化合物的发现:400 MHz NMR 的冷冻探针升级
- 批准号:
10581950 - 财政年份:2014
- 资助金额:
$ 68.61万 - 项目类别:
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