Discovery of Chemical Probes and Therapeutic Leads

描述(申请人提供)：在这个科布雷，开发化学探针和治疗线索的新方法将由不同的科学家团队追求。Cobre将为高通量筛查创建新的文库，为先天性免疫反应和神经退行性疾病提供新的视角，使新的筛查技术成为可能，并推动虚拟筛查的最新技术。拟议的Cobre将通过五个子项目在整个UD园区建立一个科学合作网络： 1.免疫刺激小分子文库的研制 2.用于高通量药物筛选的神经疾病体外模型 3.多种小分子文库制备的新方法 4.用于快速化学探针识别的电化学化学发光阵列和发射体 5.实现高通量虚拟筛选的预测承诺 拟议中的科布雷将在密歇根大学的科学家和内穆尔儿童癌症研究中心之间建立一个生物医学合作的区域网络。在所有五个子项目的丰富合作中，UD研究人员将与NCI的科学家广泛接触 分子靶标实验室(MTL)和化学生物实验室(CBL)，互动包括NCI科学家的指导，NCI研究生的交叉培训经验，以及跟进有希望的发现的合作机制。 有了新的核心仪器和设施，科布雷大学将增加生物医学研究的基础设施。该中心的范围将进一步扩大，通过教师招聘和种子资助，并通过明确的机制，将促进生物和化学后续的初步发现。Cobre还将建立一个指导网络，支持助理教师的职业发展，并将他们置于加快独立资助的道路上。

DESCRIPTION (provided by applicant): In this COBRE, novel approaches to developing chemical probes and therapeutic leads will be pursued by a diverse team of scientists. This COBRE will create new libraries for high-throughput screening, provide new perspectives on innate immune response and neurodegenerative disease, enable new screening technology, and advance the state of the art in virtual screening. The proposed COBRE will build a network of scientific collaboration throughout the UD campus through five subprojects: 1. Development of an Immunostimulatory Small Molecule Library 2. In vitro neural disease models for high throughput drug screening 3. New Synthetic Methods for Diverse Small Molecule Library Preparation 4. Electrochemical Chemiluminescent Arrays and Emitters for Rapid Chemical Probe Identification 5. Realizing the predictive promise of high throughput virtual screening The proposed COBRE will establish a regional network of biomedical collaboration between scientists at UD and the Nemours Center for Childhood Cancer Research. In a rich collaboration across all five subprojects, UD researchers will interface extensively with scientists from the NCI Molecular Targets Laboratory (MTL) and Chemical Biology Laboratories (CBL), with interactions that include mentorship by NCI scientists, crosstraining experiences for graduate students at NCI, and collaborative mechanisms for follow-up on promising discoveries. With new core instrumentation and facilities, this COBRE will increase the infrastructure for biomedical research at UD. The scope of the center will be further expanded through faculty recruitment and seed grants, and via explicit mechanisms that will facilitate both biological and chemical follow-up on initial discoveries. This COBRE will also establish a mentoring network that will support the career development of assistant faculty, and place them on an accelerated path toward independent funding.