UAB CF Research and Translation Core Center

项目总结/摘要 UAB P30研究和翻译核心中心整合了大量外部资助的囊性 纤维化（CF）研究计划在我们的校园，建立一个创新的环境，追求，推进， 在CF相关的科学培训。在上一个供资期间，P30为以下方面作出了强有力的重要贡献： 我们研究基地的多个UAB实验室，超过70名研究人员从事与CFTR相关的研究 调节、CF发病机制和治疗转化。通过NIH中心，转化研究在 在过去的五年里，我们的研究所大大加快了速度，调查人员的广度也是如此。的丰富 在UAB的CF基础科学的发展与这种翻译扩展并行，提供了许多 在下一个供资期内，我们有机会利用这些机会，我们相应地修改了中心的结构。 利用这些机会。 P30中心允许UAB和合作研究中心的研究人员提高对CF的理解 疾病机制，并提供了新的机会，积极应用这些信息， 实验治疗学该NIH中心包括三个生物医学研究核心， CF教师努力实现共同的和基本的目标，帮助个人与CF和培养下一个 CF的领导者。核心包括：核心A：细胞模型和测定核心（B Woodworth和GM 所罗门，共同PI）;核心B：动物模型核心（DM Bedwell，PI）;和核心C：临床和转化核心 (SM Rowe和A Gaggar，Co-PI）。每个核心都提供领先的检测、专用试剂和 技术和宝贵的专业知识。P30还通过试点和可行性研究聘请了新的研究人员 中心活力不可或缺的机制，并与UAB临床和 翻译科学，使一个强大的培训环境。除了提供一个平台， 初级和高级科学家被带入该领域，试点项目作为一种快速测试令人兴奋的 尤其是从临床翻译的角度来看。两个试点和可行性项目是 拟议：项目1：V Thannickal，PI。“粘液粘弹性由氧化酶介导， 氧化蛋白交联”;和项目2：J Campos-Gomez，PI。“工程化PF噬菌体治疗 铜绿假单胞菌生物膜感染”，利用下一个时代的创新机会， 转化疾病。通过这些科学举措，P30为合作伙伴关系增加了价值。 环境CF研究在我们的机构，并处于有利地位，继续在这方面的能力，在未来， 主要专注于治疗翻译。

PROJECT SUMMARY/ABSTRACT The UAB P30 Research and Translation Core Center consolidates a large number of externally funded cystic fibrosis (CF) research programs on our campus, building an innovative environment to pursue, advance, and train in CF-related science. During the last funding period, the P30 made robust and important contributions to multiple UAB laboratories of our Research Base of over 70 investigators pursuing research relevant to CFTR modulation, CF pathogenesis, and therapeutic translation. By virtue of the NIH Center, translational research at our Institution has greatly accelerated in the past five years, as has the breadth of investigators. The richness of CF basic science at UAB has grown in parallel with this translational expansion, providing numerous opportunities to exploit in the next funding period, and we have modified the structure of the Center accordingly to take advantage of these opportunities. The P30 Center has allowed investigators at UAB and collaborating sites to improve understanding of CF disease mechanism and has furnished novel opportunities to aggressively apply this information towards experimental therapeutics. This NIH Center includes three Biomedical Research Cores that help to organize efforts of CF faculty towards the common and essential goal of helping individuals with CF and to train the next generation of CF leaders. The Cores include: Core A: Cell Model and Assay Core (B Woodworth and GM Solomon, Co-PIs); Core B: Animal Models Core (DM Bedwell, PI); and Core C: Clinical and Translational Core (SM Rowe and A Gaggar, Co-PIs). Each Core provides leading-edge assays, specialized reagents and techniques, and valued expertise. The P30 has also engaged new investigators through a Pilot and Feasibility mechanism integral to Center vitality and has a tight integration with the UAB Center for Clinical and Translational Science, enabling a robust training environment. In addition to providing a platform from which junior and senior scientists are brought into the field, Pilot Projects serve as a means of rapidly testing exciting advances, particularly from the perspective of clinical translation. Two Pilot and Feasibility Projects are proposed: Project 1: V Thannickal, PI. “Mucus Viscoelasticity is Mediated by Oxidase Enzymes through Oxidative Protein Crosslinking”; and Project 2: J Campos-Gomez, PI. “Engineered PF Phage to Treat Pseudomonas aeruginosa Biofilm Infections”, capitalizing on the next era of innovative opportunities to transform the disease. Through these scientific initiatives, the P30 has added value to a collaborative environment for CF research at our Institution, and is well-positioned to continue in this capacity in the future, with a major focus on therapeutic translation.