UAB CF Research and Translation Core Center
UAB CF 研究与翻译核心中心
基本信息
- 批准号:10673353
- 负责人:
- 金额:$ 111.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-04-01 至 2028-04-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAchievementAddressAnimal ModelAnimalsAreaBacterial InfectionsBasic ScienceBiological AssayBiological ModelsBiomedical ResearchCell LineCell modelCellsCellular AssayChronicClinicalClinical SciencesClinical TrialsCollaborationsCollectionCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDedicationsDiseaseDrug IndustryEducationEducational workshopElementsEnvironmentErythrocytesEvaluationExhibitsFacultyFeasibility StudiesFerretsFosteringFoundationsFunctional disorderFundingFutureGenerationsGeneticGoalsGrowthHemolysisHumanImageInfectionInflammationInstitutionInterdisciplinary CommunicationInterdisciplinary StudyInternationalInvestigationInvestigational TherapiesKetonesKnowledgeLaboratoriesLeadershipLungLung diseasesMeasuresMentorshipMutationNational Institute of Diabetes and Digestive and Kidney DiseasesNonsense MutationOrganoidsOutcome MeasureOutputPathogenesisPatientsPhysiologicalPilot ProjectsPopulationPositioning AttributePre-Clinical ModelPredispositionRattusReagentResearchResearch PersonnelResearch PriorityResearch SupportResourcesRoleSamplingScienceScientific Advances and AccomplishmentsSenior ScientistSeriesServicesSiteStructureSupplementationSystemTechniquesTestingTherapeuticTherapeutic InterventionTrainingTranslatingTranslational ResearchTranslationsTreatment ProtocolsUnited StatesUnited States National Institutes of HealthUniversitiesVX-770Workage relatedbasecareer developmentclinical centerclinical translationcollaborative environmentcystic fibrosis patientsdesigndrug discoveryeffectiveness researchexperiencegene therapyimprovedin vivoinnovationinventionmembermodel developmentmultidisciplinarynext generationnovelnovel therapeuticspreventprogramsrepositoryrespiratoryresponsesuccesssynergismtherapeutic evaluationtherapy developmenttooltool developmenttraining opportunitytranslational scientisttranslational therapeuticsworking group
项目摘要
PROJECT SUMMARY/ABSTRACT
The UAB P30 Research and Translation Core Center consolidates a large number of externally funded cystic
fibrosis (CF) research programs on our campus, building an innovative environment to pursue, advance, and
train in CF-related science. During the last funding period, the P30 made robust and important contributions to
multiple UAB laboratories of our Research Base of over 70 investigators pursuing research relevant to CFTR
modulation; CF pathogenesis; novel outcome measures for the genetic therapy era; infection and inflammation
in the context of highly effective modulator therapy; and therapeutic translation for untreated CFTR mutations.
By virtue of the NIH Center, translational research at our Institution has continued to accelerate in the past five
years, as has the breadth of investigators. The richness of CF basic science at UAB has grown in parallel with
this translational expansion, providing numerous opportunities to exploit in the next funding period, and the
Center is strategically structured to take advantage of these opportunities.
The P30 Center has allowed investigators at UAB and collaborating sites to improve understanding of CF
disease mechanism and has furnished novel opportunities to aggressively apply this information towards
experimental therapeutics, including genetic-based therapies that will continue to grow in emphasis. This NIH
Center includes three Biomedical Research Cores that help to organize efforts of CF faculty towards the
common and essential goal of helping individuals with CF and to train the next generation of CF leaders. The
Cores include: Core A: Cell Model and Assay Core (GM Solomon and J Guimbellot, Co-PIs); Core B: Animal
Models Core (DM Bedwell and S Birket, Co-PIs); and Core C: Clinical and Translational Core (SM Rowe and A
Gaggar, Co-PIs). Each Core provides leading-edge assays, specialized reagents and techniques, and valued
expertise. The P30 has also engaged new investigators through a Pilot and Feasibility mechanism integral to
Center vitality and has a tight integration with the UAB Center for Clinical and Translational Science, enabling a
robust training environment. In addition to providing a platform from which junior and senior scientists are
brought into the field, Pilot Projects serve as a means of rapidly testing exciting advances, particularly from the
perspective of clinical translation. Two Pilot and Feasibility Projects are in progress: Project 1: R Patel, PI.
“Erythrocyte Hemolysis and Lung Disease in CF”; and Project 2: E Plaisance, PI. “Ketone Monoester
Supplementation in CF: A Pilot and Feasibility Study”, capitalizing on the next era of innovative opportunities to
transform the disease. Through these scientific initiatives, the P30 has added value to a collaborative
environment for CF research at our Institution, and is well-positioned to continue in this capacity in the future,
with a major focus on therapeutic translation.
项目摘要/摘要
UAB P30研究和翻译核心中心整合了大量外部资金的囊性
我们校园内的纤维化(CF)研究计划,构建一个创新的环境,以追求、推进和
接受过CF相关科学方面的培训。在上一个筹资期间,P30作出了有力和重要的贡献,
UAB的多个实验室,我们的研究基地有70多名研究人员,从事与CFTR相关的研究
调节;CF发病机制;基因治疗时代的新结果衡量标准;感染和炎症
在高效调节剂治疗的背景下;以及对未经治疗的CFTR突变的治疗性翻译。
借助美国国立卫生研究院中心,我们研究所的翻译研究在过去五年中继续加速
几年来,调查人员的广度也是如此。加州大学伯克利分校CF基础科学的丰富性与
这种翻译扩展,在下一个资金期提供了大量的机会来利用,并且
Center的战略架构是为了利用这些机会。
P30中心允许UAB和合作站点的调查人员提高对CF的理解
疾病机制,并提供了新的机会,积极地应用这些信息来
实验疗法,包括将继续受到重视的基于遗传的疗法。这家美国国立卫生研究院
中心包括三个生物医学研究中心,帮助组织CF教职员工为
共同的和基本的目标是帮助患有CF的个人,并培养下一代CF领导者。这个
核心包括:核心A:细胞模型和分析核心(GM所罗门和J Guimbellot,Co-PI);核心B:动物
模型核心(DM Bedwell和S Birket,Co-PI);以及核心C:临床和翻译核心(SM Rowe和A
Gaggar,Co-PI)。每个核心提供尖端的分析,专门的试剂和技术,并重视
专业知识。P30还通过试点和可行性机制聘请了新的调查人员,这是
中心充满活力,并与UAB临床和转化科学中心紧密集成,使
良好的培训环境。除了提供一个平台,初级和高级科学家
将试点项目带入实地,作为一种快速测试激动人心的进步的手段,特别是来自
临床翻译的视角。两个试验性和可行性项目正在进行中:项目1:R Patel,PI。
“慢性粒细胞白血病中的红细胞溶血和肺部疾病”;和项目2:E Plaisance,PI。“酮单酯
在合作伙伴关系中的补充:试点和可行性研究“,利用创新机会的下一个时代
改变疾病。通过这些科学计划,P30为协作
为我们研究所的CF研究创造了良好的环境,并处于有利地位,将在未来继续担任这一职务。
主要集中在治疗性翻译上。
项目成果
期刊论文数量(380)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Resveratrol ameliorates abnormalities of fluid and electrolyte secretion in a hypoxia-Induced model of acquired CFTR deficiency.
- DOI:10.1002/lary.25335
- 发表时间:2015-10
- 期刊:
- 影响因子:0
- 作者:Woodworth BA
- 通讯作者:Woodworth BA
Generation of chromosome 1p/19q co-deletion by CRISPR/Cas9-guided genomic editing.
- DOI:10.1093/noajnl/vdac131
- 发表时间:2022-01
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia.
- DOI:10.1364/ol.42.000867
- 发表时间:2017-02-15
- 期刊:
- 影响因子:3.6
- 作者:Cui D;Chu KK;Yin B;Ford TN;Hyun C;Leung HM;Gardecki JA;Solomon GM;Birket SE;Liu L;Rowe SM;Tearney GJ
- 通讯作者:Tearney GJ
Effect of lumacaftor-ivacaftor on mucociliary clearance and clinical outcomes in cystic fibrosis: Results from the PROSPECT MCC sub-study.
- DOI:10.1016/j.jcf.2021.05.004
- 发表时间:2022-01
- 期刊:
- 影响因子:0
- 作者:Donaldson SH;Laube BL;Mogayzel P;Corcoran TE;Pilewski JM;Ceppe A;Wu J;Bhambhvani PG;Ratjen F;Sagel SD;Clancy JP;Rowe SM;Bennett WD
- 通讯作者:Bennett WD
DeltaF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers.
- DOI:10.1016/j.pupt.2010.02.001
- 发表时间:2010-08
- 期刊:
- 影响因子:3.2
- 作者:Rowe SM;Pyle LC;Jurkevante A;Varga K;Collawn J;Sloane PA;Woodworth B;Mazur M;Fulton J;Fan L;Li Y;Fortenberry J;Sorscher EJ;Clancy JP
- 通讯作者:Clancy JP
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David M. Bedwell其他文献
Long-term nonsense suppression therapy with NB84 moderates MPS IH disease progression
- DOI:
10.1016/j.ymgme.2013.12.106 - 发表时间:
2014-02-01 - 期刊:
- 影响因子:
- 作者:
Gwendolyn G. Gunn;Yanying Dai;Ming Du;Valery Beklakhov;Jeyakumar Kandasamy;Trenton R. Schoeb;Timor Baasov;David M. Bedwell;Kim M. Keeling - 通讯作者:
Kim M. Keeling
The nonsense suppression drug PTC124 restored alpha-<span class="small-caps">l</span>-iduronidase activity and reduces glycosaminoglycan accumulation in MPS IH mice carrying the Idua-W402X mutation
- DOI:
10.1016/j.ymgme.2014.12.026 - 发表时间:
2015-02-01 - 期刊:
- 影响因子:
- 作者:
David M. Bedwell;Dan Wang;Ellen M. Welch;Kim M. Keeling - 通讯作者:
Kim M. Keeling
David M. Bedwell的其他文献
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{{ truncateString('David M. Bedwell', 18)}}的其他基金
New Nonsense Suppression Drugs to Treat MPS I
治疗 MPS I 的新型无意义抑制药物
- 批准号:
8842247 - 财政年份:2014
- 资助金额:
$ 111.38万 - 项目类别:
Suppression of the Idua-W402X mutation in an MPS I-H mouse
MPS I-H 小鼠 Idua-W402X 突变的抑制
- 批准号:
7340377 - 财政年份:2007
- 资助金额:
$ 111.38万 - 项目类别:
Suppression of the Idua-W402X mutation in an MPS I-H mouse
MPS I-H 小鼠 Idua-W402X 突变的抑制
- 批准号:
7179609 - 财政年份:2007
- 资助金额:
$ 111.38万 - 项目类别:
Suppression of the Idua-W402X mutation in an MPS I-H mouse
MPS I-H 小鼠 Idua-W402X 突变的抑制
- 批准号:
8015606 - 财政年份:2007
- 资助金额:
$ 111.38万 - 项目类别:
Suppression of the Idua-W402X mutation in an MPS I-H mouse
MPS I-H 小鼠 Idua-W402X 突变的抑制
- 批准号:
7560341 - 财政年份:2007
- 资助金额:
$ 111.38万 - 项目类别:
UAB CF Research and Translation Core Center
UAB CF 研究与翻译核心中心
- 批准号:
10468801 - 财政年份:2007
- 资助金额:
$ 111.38万 - 项目类别:
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