2022 Metals in Medicine Gordon Research Conference

2022 年戈登医学金属研究会议

• 批准号: 10469045
• 负责人: Edith C Glazer
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469045
• 关键词: Academia; Address; Area; Basic Science; Bioinorganic Chemistry; Career Mobility; Catalysis; Cells; Chemicals; Chemistry; Clinical; Communities; Complex; Contrast Media; Data; Developing Countries; Development; Diagnosis; Diagnostic; Disease; Early Diagnosis; Ensure; Environment; Etiology; Fertilization; Fostering; Funding; Government; Growth; Health; Hour; Human; Image; Industry; International; Learning; Magnetic Resonance Imaging; Medical; Medicine; Mentors; Metals; Methods; Mission; Modernization; Molecular; Nanotechnology; Oral; Participant; Pathologic; Pharmaceutical Preparations; Positron-Emission Tomography; Postdoctoral Fellow; Process; Property; Proteins; Radioisotopes; Radionuclide therapy; Research; Research Personnel; Role; Science; Scientist; Social Interaction; Stimulus; System; Technology; Therapeutic; Therapeutic Agents; Trace metal; Translating; Translations; United States National Institutes of Health; Visit; Woman; Work; base; career; catalyst; chelation; clinical translation; design; disease diagnosis; experience; graduate student; improved; informal atmosphere; innovation; meetings; metal complex; multidisciplinary; nanomaterials; nanoscale; nanoscience; nanotheranostics; new technology; next generation; novel; personalized medicine; posters; preclinical evaluation; programs; research clinical testing; small molecule; symposium; theranostics; tool

PROJECT SUMMARY/ABSTRACT The mission of the Metals in Medicine Gordon Research Conference (GRC) is to cultivate a community of multidisciplinary scientists focused on improving human health by translating basic science discoveries in the areas of bioinorganic chemistry, materials, and inorganic nanotechnology to medical application. The 2022 Metals in Medicine GRC will bring together more than 150 scientists and clinicians from around the world in academia, industry and government to discuss the latest developments in the field in the intimate and informal environment of a GRC. The organizers have three specific aims: 1) Showcase how the properties intrinsic to metals and inorganic materials can be leveraged to develop transformative new chemical and nano-scale entities for use in the diagnosis, imaging, and treatment of disease; 2) Highlight the development of new systems and optimization of existing technologies to aid in understanding the roles of metals in the pathological basis for disease and medical treatments; 3) Provide a stimulating and dynamic gathering to engage and inspire young scientists in this evolving field. The theme of the 2022 meeting is “Advancing the use of metal-based compounds and nanotheranostics for personalized medicine.” Aim 1 is addressed by emphasizing the unique features of metals to support human health. Several sessions mix basic science with advanced pre-clinical and clinical evaluation. The program opens with Supramolecular Coordination Complexes for Biomedical Applications, which will feature the latest innovations in nanoscience as it relates to self-assembling molecular systems and nanomaterials as theranostics. Novel Chelation Strategies and Applications for Radionuclides and Contrast Agents focuses on stably complexing metals to bioconjugates for diagnostics (PET and MRI), and for targeted radionuclide therapy. There will be two sessions on metal-based therapeutics (Stimuli-responsive Materials for Therapy and Imaging and Targeted Metal-based Therapeutics). Clinical Advances for Metals in Medicine will discuss metal-based diagnostics and therapeutics that are in early human trials. Aim 2 is achieved with sessions focusing on basic research and early development of new technologies. The role of specific metals in the etiology of disease will be presented in the session Essential Metals in Disease Mechanisms, and the emerging area of Catalysis in Cells highlights advances in this traditional application of metals in an untraditional environment. Novel Metallomics Methods and Tools presents approaches and technologies to detect, quantify, and trace metals and inorganic materials. The Early Career Investigators/Emerging Topics session will complete the program, and supports Aim 3, with an emphasis on encourage early career investigators. Speakers will also be selected from the submitted abstracts, achieving 25% representation from early stage scientists and ensuring that the most exciting new discoveries are presented. Other program features focused include “Poster Previews”, the “Power Hour” to address issues around career advancement for STEM women scientists, and many informal activities.

项目总结/摘要 戈登医学研究会议（GRC）的使命是培养一个 多学科科学家致力于通过将基础科学发现转化为 从生物无机化学、材料、无机纳米技术到医学应用。2022年 医学中的金属GRC将汇集来自世界各地的150多名科学家和临床医生， 学术界，工业界和政府讨论在该领域的最新发展，在亲密和非正式的 一个GRC的环境组织者有三个具体目标：1）展示如何固有的属性， 金属和无机材料可以用来开发具有变革性的新型化学和纳米级实体 用于疾病的诊断、成像和治疗; 2）突出新系统的开发， 优化现有技术，以帮助了解金属在病理基础中的作用， 疾病和医疗; 3）提供一个刺激和充满活力的聚会，以吸引和激励年轻人 科学家在这个不断发展的领域。 2022年会议的主题是“推进金属基化合物和纳米治疗诊断学的使用， 个性化医疗”。目标1是通过强调金属的独特特性来支持人类 健康一些会议将基础科学与先进的临床前和临床评估相结合。程序打开 与生物医学应用的超分子配位络合物，这将具有最新的 创新的纳米科学，因为它涉及到自组装分子系统和纳米材料， 治疗诊断学放射性核素和造影剂的新型螯合策略和应用 稳定地将金属络合到生物缀合物上，用于诊断（PET和MRI）和用于靶向放射性核素治疗。 将有两个会议的金属为基础的治疗（刺激响应材料的治疗和成像 和靶向金属基治疗剂）。医学中金属的临床进展将讨论金属基 早期的人体试验中的诊断和治疗方法。目标2是通过侧重于基本 研究和早期开发新技术。特定金属在疾病病因学中的作用将 将在疾病机制中的基本金属会议上提出，以及催化的新兴领域， 细胞突出了在非传统环境中金属的这种传统应用的进展。小说 金属组学方法和工具介绍了检测、量化和跟踪金属的方法和技术， 无机材料早期职业调查员/新兴主题会议将完成该计划， 支持目标3，重点是鼓励早期职业调查人员。发言人也将从以下方面选出： 提交的摘要，达到25%的代表性，从早期阶段的科学家，并确保最 令人兴奋的新发现。其他节目功能重点包括“海报预览”，“权力” 小时”，以解决围绕STEM女科学家的职业发展问题，以及许多非正式活动。